Results 1 to 10 of about 746,792 (308)

Circulating tumor DNA as a dynamic biomarker of response to palbociclib and fulvestrant in metastatic breast cancer patients

Breast Cancer Research, 2021
Background Following the PALOMA-3 study results, the combination of palbociclib, a CDK4/6 inhibitor, with fulvestrant, a selective estrogen receptor degrader, has become a standard therapy in women with estrogen receptor-positive (ER+) HER2-negative ...
Lauren Darrigues, Jean-Yves Pierga, Alice Bernard-Tessier, Ivan Bièche, Amanda Bartolini Silveira, Marc Michel, Delphine Loirat, Paul Cottu, Luc Cabel, Coraline Dubot, Romain Geiss, Francesco Ricci, Anne Vincent-Salomon, Charlotte Proudhon, François-Clément Bidard   +14 more
doaj   +1 more source

The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma

Scientific Reports, 2023
Renal cancer cells constitute a paradigm of tumor cells with a glycolytic reprogramming which drives metabolic alterations favouring cell survival and transformation.
Caroline E. Nunes-Xavier, Maite Emaldi, Janire Mingo, Tove Øyjord, Gunhild M. Mælandsmo, Øystein Fodstad, Peio Errarte, Gorka Larrinaga, Roberto Llarena, José I. López, Rafael Pulido   +10 more
doaj   +1 more source

Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer

Frontiers in Oncology, 2022
BackgroundPyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by pyruvate decarboxylation, which drives energy metabolism during cell growth, including prostate cancer (PCa) cell growth.
Caroline E. Nunes-Xavier, Caroline E. Nunes-Xavier, Janire Mingo, Maite Emaldi, Karine Flem-Karlsen, Gunhild M. Mælandsmo, Øystein Fodstad, Roberto Llarena, José I. López, José I. López, Rafael Pulido, Rafael Pulido   +11 more
doaj   +1 more source

A Diagnostic Model With IgM Autoantibodies and Carcinoembryonic Antigen for Early Detection of Lung Adenocarcinoma

Frontiers in Immunology, 2022
Immunoglobulin M (IgM) autoantibodies, as the early appearing antibodies in humoral immunity when stimulated by antigens, might be excellent biomarkers for the early detection of lung cancer (LC).
Xue Zhang, Xue Zhang, Jiaqi Li, Jiaqi Li, Yulin Wang, Yulin Wang, Man Liu, Man Liu, Fenghui Liu, Xiuzhi Zhang, Lu Pei, Tingting Wang, Di Jiang, Di Jiang, Xiao Wang, Xiao Wang, Jianying Zhang, Jianying Zhang, Liping Dai, Liping Dai   +19 more
doaj   +1 more source

Multimodal liquid biopsy for early monitoring and outcome prediction of chemotherapy in metastatic breast cancer

npj Breast Cancer, 2021
Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) are two cancer-derived blood biomarkers that inform on patient prognosis and treatment efficacy in breast cancer.
Amanda Bortolini Silveira, François-Clément Bidard, Marie-Laure Tanguy, Elodie Girard, Olivier Trédan, Coraline Dubot, William Jacot, Anthony Goncalves, Marc Debled, Christelle Levy, Jean-Marc Ferrero, Christelle Jouannaud, Maria Rios, Marie-Ange Mouret-Reynier, Florence Dalenc, Caroline Hego, Aurore Rampanou, Benoit Albaud, Sylvain Baulande, Frédérique Berger, Jérôme Lemonnier, Shufang Renault, Isabelle Desmoulins, Charlotte Proudhon, Jean-Yves Pierga   +24 more
doaj   +1 more source

A DNA methylation-based liquid biopsy for triple-negative breast cancer

npj Precision Oncology, 2021
Here, we present a next-generation sequencing (NGS) methylation-based blood test called methylation DETEction of Circulating Tumour DNA (mDETECT) designed for the optimal detection and monitoring of metastatic triple-negative breast cancer (TNBC).
Katrina Cristall, Francois-Clement Bidard, Jean-Yves Pierga, Michael J. Rauh, Tatiana Popova, Clara Sebbag, Olivier Lantz, Marc-Henri Stern, Christopher R. Mueller   +8 more
doaj   +1 more source

Identification of novel biomarkers with potential for diagnosis and prognosis of gastric cancer: a Bioinformatics Approach

ABCS Health Sciences, 2023
Introduction: Gastric cancer (GC) is the fifth most diagnosed neoplasia and the third leading cause of cancer-related deaths. A substantial number of patients exhibit an advanced GC stage once diagnosed.
Marcos Vinicius Rossetto, Fernanda Pessi de Abreu, Pedro Lenz Casa, Ivaine Tais Sauthier Sartor, Scheila de Avila e Silva   +4 more
doaj   +3 more sources

Structural Relationship between Cerebral Gray and White Matter Alterations in Degenerative Cervical Myelopathy

Tomography, 2023
Patients with degenerative cervical myelopathy (DCM) undergo adaptive supraspinal changes. However, it remains unknown how subcortical white matter changes reflect the gray matter loss.
Chencai Wang, Francesco Sanvito, Talia C. Oughourlian, Sabah Islam, Noriko Salamon, Langston T. Holly, Benjamin M. Ellingson   +6 more
doaj   +1 more source

Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. [PDF]

, 2020
Although immunotherapies have achieved remarkable salutary effects among subgroups of advanced cancers, most patients do not respond. We comprehensively evaluated biomarkers associated with the "cancer-immunity cycle" in the pan-cancer setting in order ...
Dressman, Devin, Eskander, Ramez, Glenn, Sean T, Goodman, Aaron, Ikeda, Sadakatsu, Kato, Shumei, Kumaki, Yuichi, Kurzrock, Razelle, Lee, Suzanna, Lenzo, Felicia L, Morrison, Carl, Nikanjam, Mina, Okamura, Ryosuke, Papanicolau-Sengos, Antonios   +13 more
core   +1 more source

Circulating extracellular vesicles provide valuable protein, but not DNA, biomarkers in metastatic breast cancer

Journal of Extracellular Biology, 2022
Detection of cell‐free circulating tumour DNA (ctDNA) and cancer‐specific extracellular vesicles (EVs) in patient blood have been widely explored as non‐invasive biomarkers for cancer detection and disease follow up.
Mercedes Tkach, Caroline Hego, Marc Michel, Lauren Darrigues, Jean‐Yves Pierga, François‐Clément Bidard, Clotilde Théry, Charlotte Proudhon   +7 more
doaj   +1 more source