Results 1 to 10 of about 3,850,355 (295)

Stemness subtypes in lower-grade glioma with prognostic biomarkers, tumor microenvironment, and treatment response. [PDF]

Sci Rep
Our research endeavors are directed towards unraveling the stem cell characteristics of lower-grade glioma patients, with the ultimate goal of formulating personalized treatment strategies.
Ye S, Yang B, Yang L, Wei W, Fu M, Yan Y, Wang B, Li X, Liang C, Zhao W.   +9 more
europepmc   +2 more sources

Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance. [PDF]

Hereditas
Background Gastric cancer (GC) presents a significant global health burden, necessitating a deeper understanding of its molecular underpinnings for improved diagnostics and therapeutics.
Wei S, Li Y, Zhou J, Xia Y.
europepmc   +2 more sources

Circulating tumor DNA as a dynamic biomarker of response to palbociclib and fulvestrant in metastatic breast cancer patients

Breast Cancer Research, 2021
Background Following the PALOMA-3 study results, the combination of palbociclib, a CDK4/6 inhibitor, with fulvestrant, a selective estrogen receptor degrader, has become a standard therapy in women with estrogen receptor-positive (ER+) HER2-negative ...
Lauren Darrigues, Jean-Yves Pierga, Alice Bernard-Tessier, Ivan Bièche, Amanda Bartolini Silveira, Marc Michel, Delphine Loirat, Paul Cottu, Luc Cabel, Coraline Dubot, Romain Geiss, Francesco Ricci, Anne Vincent-Salomon, Charlotte Proudhon, François-Clément Bidard   +14 more
doaj   +1 more source

DNA nanotechnology in tumor liquid biopsy: Enrichment and determination of circulating biomarkers

Interdisciplinary Medicine, 2023
Monitoring tumor biomarkers in a non‐invasive manner for tumor diagnosis has attracted increasing attention. Liquid biopsy mainly includes three types of biomarkers: circulating tumor cells, extracellular vesicles, and circulating nucleic acids.
Yitong Zhu, Wenbin Li, Fei Lan, Siting Chen, Xiaofei Chen, Xiaohe Zhang, Xiaohui Yan, Ye Zhang   +7 more
semanticscholar   +1 more source

Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response

Signal Transduction and Targeted Therapy, 2022
Cancers are highly complex diseases that are characterized by not only the overgrowth of malignant cells but also an altered immune response. The inhibition and reprogramming of the immune system play critical roles in tumor initiation and progression ...
Dongrui Wang, Xian Wu, Yingchaun Sun
semanticscholar   +1 more source

Identification of novel biomarkers with potential for diagnosis and prognosis of gastric cancer: a Bioinformatics Approach

ABCS Health Sciences, 2023
Introduction: Gastric cancer (GC) is the fifth most diagnosed neoplasia and the third leading cause of cancer-related deaths. A substantial number of patients exhibit an advanced GC stage once diagnosed.
Marcos Vinicius Rossetto, Fernanda Pessi de Abreu, Pedro Lenz Casa, Ivaine Tais Sauthier Sartor, Scheila de Avila e Silva   +4 more
doaj   +3 more sources

Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer

Frontiers in Oncology, 2022
BackgroundPyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by pyruvate decarboxylation, which drives energy metabolism during cell growth, including prostate cancer (PCa) cell growth.
Caroline E. Nunes-Xavier, Caroline E. Nunes-Xavier, Janire Mingo, Maite Emaldi, Karine Flem-Karlsen, Gunhild M. Mælandsmo, Øystein Fodstad, Roberto Llarena, José I. López, José I. López, Rafael Pulido, Rafael Pulido   +11 more
doaj   +1 more source

The expression pattern of pyruvate dehydrogenase kinases predicts prognosis and correlates with immune exhaustion in clear cell renal cell carcinoma

Scientific Reports, 2023
Renal cancer cells constitute a paradigm of tumor cells with a glycolytic reprogramming which drives metabolic alterations favouring cell survival and transformation.
Caroline E. Nunes-Xavier, Maite Emaldi, Janire Mingo, Tove Øyjord, Gunhild M. Mælandsmo, Øystein Fodstad, Peio Errarte, Gorka Larrinaga, Roberto Llarena, José I. López, Rafael Pulido   +10 more
doaj   +1 more source

A Diagnostic Model With IgM Autoantibodies and Carcinoembryonic Antigen for Early Detection of Lung Adenocarcinoma

Frontiers in Immunology, 2022
Immunoglobulin M (IgM) autoantibodies, as the early appearing antibodies in humoral immunity when stimulated by antigens, might be excellent biomarkers for the early detection of lung cancer (LC).
Xue Zhang, Xue Zhang, Jiaqi Li, Jiaqi Li, Yulin Wang, Yulin Wang, Man Liu, Man Liu, Fenghui Liu, Xiuzhi Zhang, Lu Pei, Tingting Wang, Di Jiang, Di Jiang, Xiao Wang, Xiao Wang, Jianying Zhang, Jianying Zhang, Liping Dai, Liping Dai   +19 more
doaj   +1 more source

Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors

Nature Communications, 2021
Treatment with immune checkpoint inhibitors (ICI) has demonstrated clinical benefit for a wide range of cancer types. Because only a subset of patients experience clinical benefit, there is a strong need for biomarkers that are easily accessible across ...
C. Valero, Mark Lee, Douglas R. Hoen, K. Weiss, D. Kelly, P. Adusumilli, P. Paik, G. Plitas, M. Ladanyi, M. Postow, C. Ariyan, A. Shoushtari, V. Balachandran, A. Hakimi, A. Crago, K. L. Long Roche, J. Smith, I. Ganly, R. Wong, S. Patel, J. Shah, N. Lee, N. Riaz, Jingming Wang, A. Zehir, M. Berger, T. Chan, V. Seshan, L. Morris   +28 more
semanticscholar   +1 more source