Results 211 to 220 of about 4,189,421 (356)

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Longitudinal Study of Salivary Biomarkers in the Definition of Clinico‐Molecular Progression of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo, Daniele Belvisi, Matteo Costanzo, Claudia Caturano, Francesco Emanuele Bellomi, Carolina Cutrona, Flavia Aiello, Giorgio Leodori, Massimo Marano, Romina Mancinelli, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli, Giorgio Vivacqua   +13 more
wiley   +1 more source

Advances in biomarkers of resistance to KRAS mutation-targeted inhibitors. [PDF]

Discov Oncol
Wang L, Wei D, Li S, Jiang S.
europepmc   +1 more source

Exploring Nasal Structural‐Microbial Interactions in Multiple Sclerosis‐Associated Olfactory Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Olfactory dysfunction is frequently observed in patients with multiple sclerosis (MS); however, its underlying mechanisms remain poorly understood. To date, no studies have directly examined the nasal mucosal microbiota in MS. This study aimed to explore potential relationships among olfactory function, nasal microbiota composition,
Zidan Gao, Zhuoma Danzhen, Yao Li, Junyu Zhu, Lan Chu, Zhang Yang   +5 more
wiley   +1 more source

Evaluating the GALAD Score for Detection of Hepatocellular Carcinoma in Patients With Cirrhosis. [PDF]

J Clin Gastroenterol
Vo TD, Mai SH, Lam HT.
europepmc   +1 more source

Analysis of Soluble Interleukin‐2 Receptor as a Prognostic Biomarker in NMOSD and MOGAD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Soluble interleukin‐2 receptor (sIL‐2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) pathogenesis. However, sIL‐2R has so far not been evaluated in these conditions.
Philipp Klyscz, Carolin Otto, Klemens Ruprecht, Susanna Asseyer, Hannes Ole Tiedt, Christian Meisel, Judith Bellmann‐Strobl, Friedemann Paul, Patrick Schindler   +8 more
wiley   +1 more source

Integrating AI and RNA biomarkers in cancer: advances in diagnostics and targeted therapies. [PDF]

Cell Commun Signal
Hussen BM, Abdullah SR, Hidayat HJ, Samsami M, Taheri M.   +4 more
europepmc   +1 more source

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothe

Advances in Anatomic Pathology, 2017
S. Hendry, R. Salgado, T. Gevaert, P. Russell, T. John, T. John, B. Thapa, M. Christie, K. V. D. Vijver, M. V. Estrada, Paula I. Gonzalez-Ericsson, M. Sanders, B. Solomon, C. Solinas, G. V. D. Eynden, Y. Allory, Y. Allory, M. Preusser, J. Hainfellner, G. Pruneri, A. Vingiani, S. Demaria, F. Symmans, P. Nuciforo, L. Comerma, E. Thompson, S. Lakhani, S. Lakhani, Seong-Rim Kim, S. Schnitt, C. Colpaert, C. Sotiriou, S. Scherer, M. Ignatiadis, S. Badve, R. Pierce, G. Viale, N. Sirtaine, F. Penault-Llorca, Tomohagu Sugie, S. Fineberg, S. Paik, A. Srinivasan, A. Richardson, Yihong Wang, Yihong Wang, E. Chmielik, J. Brock, Douglas B. Johnson, J. Balko, S. Wienert, V. Bossuyt, S. Michiels, N. Ternès, N. Burchardi, S. Luen, S. Luen, P. Savas, P. Savas, F. Klauschen, P. Watson, B. Nelson, B. Nelson, C. Criscitiello, S. O'toole, D. Larsimont, R. Wind, G. Curigliano, F. André, M. Lacroix-Triki, Mark van de Vijver, F. Rojo, G. Floris, S. Bedri, J. Sparano, D. Rimm, T. Nielsen, Z. Kos, S. Hewitt, Baljit Singh, G. Farshid, S. Loibl, K. Allison, N. Tung, S. Adams, K. Willard-Gallo, H. Horlings, L. Gandhi, L. Gandhi, Andre Moreira, F. Hirsch, M. Dieci, M. Urbanowicz, I. Brčić, Konstanty Korski, F. Gaire, H. Koeppen, A. Lo, A. Lo, J. Giltnane, M. Rebelatto, K. Steele, J. Zha, K. Emancipator, J. Juco, C. Denkert, J. Reis-Filho, S. Loi, S. Fox   +108 more
semanticscholar   +1 more source

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Cancer Biomarkers: Reflection on Recent Progress, Emerging Innovations, and the Clinical Horizon. [PDF]

Cancers (Basel)
Qoronfleh MW, Al-Dewik N.
europepmc   +1 more source