Results 251 to 260 of about 4,106,951 (336)

Relationship between Tumor Biomarkers and Efficacy in EMILIA, a Phase III Study of Trastuzumab Emtansine in HER2-Positive Metastatic Breast Cancer

Clinical Cancer Research, 2016
J. Baselga, Gail D Lewis Phillips, S. Verma, J. Ro, J. Huober, A. Guardino, M. Samant, S. Olsen, S. de Haas, M. Pegram   +9 more
semanticscholar   +1 more source

An Animal‐Free Patient‐Derived Tissue‐Mimetic Biochip Model of the Human Synovial Membrane for Human‐Relevant Osteoarthritis Research

Advanced Healthcare Materials, EarlyView.
Reihs et al. present the development of a humanized, animal‐free synovial membrane model for osteoarthritis. Methods include 3D biochip cultures of human‐primary OA synoviocytes with matrix and serum surrogates. Results show replication of synovial architecture and increased Yap1 expression.
Eva I. Reihs, Alexander Stoegner, Mateo G. Vasconez Martínez, Markus M. Schreiner, Melanie Cezanne, Ruth Gruebl‐Barabas, Bettina Rodriguez‐Molina, Juergen Alphonsus, Silvia Hayer, Richard Lass, Iris Gerner, Florien Jenner, Wolfgang Holnthoner, Stefan Toegel, Peter Ertl, Hans P. Kiener, Reinhard Windhager, Mario Rothbauer   +17 more
wiley   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

SITC perspective: leveraging patient enrichment biomarkers to accelerate early phase IO drug development. [PDF]

J Immunother Cancer
Emens LA, Moussion C, Hwu P, Gulley JL, Ohashi PS, Bifulco CB, Feltquate D.   +6 more
europepmc   +1 more source

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

The heterogeneous expression patterns of serum tumor markers in non-small cell lung cancer patients are predictive factors for progression-free survival. [PDF]

Discov Oncol
Li S, Zeng Z, Hong Z, Li J, Xie C.
europepmc   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Single-Gene Mutations in Hepatocellular Carcinoma: Applications and Challenges in Precision Medicine. [PDF]

Int J Med Sci
Yu H, Wu X, Liu Y, Xin C, Zhou Y, Ding X.   +5 more
europepmc   +1 more source

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

Nature Genetics, 2019
R. Samstein, Chung-Han Lee, A. Shoushtari, M. Hellmann, R. Shen, Y. Janjigian, D. Barron, A. Zehir, E. Jordan, A. Omuro, T. Kaley, S. Kendall, R. Motzer, A. Hakimi, M. Voss, P. Russo, J. Rosenberg, G. Iyer, B. Bochner, D. Bajorin, H. Al-Ahmadie, J. Chaft, C. Rudin, Gregory Riely, S. Baxi, A. Ho, R. Wong, D. Pfister, J. Wolchok, C. Barker, P. Gutin, C. Brennan, V. Tabar, I. Mellinghoff, L. Deangelis, C. Ariyan, N. Lee, W. Tap, M. Gounder, S. D’Angelo, L. Saltz, Z. Stadler, H. Scher, J. Baselga, P. Razavi, C. Klebanoff, R. Yaeger, N. Segal, G. Ku, R. DeMatteo, M. Ladanyi, N. Rizvi, M. Berger, N. Riaz, D. Solit, T. Chan, L. Morris   +56 more
semanticscholar   +1 more source

Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy

Advanced Healthcare Materials, EarlyView.
This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley   +1 more source