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A Quantitative Structure-Activity Relationship for Human Plasma Protein Binding: Prediction, Validation and Applicability Domain [PDF]
Advanced Pharmaceutical Bulletin, 2023 Purpose: The purpose of this study was to develop a robust and externally predictive in silico QSAR-neural network model for predicting plasma protein binding of drugs. This model aims to enhance drug discovery processes by reducing the need for chemical
Affaf Khaouane +2 more
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Sleep Apnea Severity Estimation From Tracheal Movements Using a Deep Learning Model
IEEE Access, 2020 Objective: Sleep apnea is a chronic respiratory disorder and its standard assessment requires full night in-laboratory polysomnography (PSG). However, PSG is expensive, time-consuming, and inconvenient.
Maziar Hafezi +6 more
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Bone quality effect on short implants in the edentulous mandible: a finite element study
BMC Oral Health, 2022 Introduction The aim of this study was to verify whether the use of short implants could optimize stress distribution of bone surrounding implants in atrophic mandibles with different bone qualities.
Chaowei Liu +5 more
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Frontiers in Pharmacology, 2021 Alnus hirsuta (Spach) Rupr. (AH), a member of the Betulaceae family, is widely used in Eastern Asia of as a source of medicinal compounds for the treatment of hemorrhage, diarrhea, and alcoholism.
Ba-Wool Lee +13 more
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Antioxidants, 2020 Lindera obtusiloba is widespread in northeast Asia and used for treatment of improvement of blood circulation and anti-inflammation. In this study, we investigated anti-inflammatory and anti-oxidant effects of the methanolic extract of L.
Ba-Wool Lee +12 more
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Journal of Immunology Research, 2018 Tumor is the most serious threat to human beings. Although war against cancer has been launched over forty years, cancer treatment is still far away from being satisfactory.
Huan Zhao +3 more
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Heliyon, 2023 Vigna angularis is an edible crop and herbal medicine that is known to have antipyretic, anti-inflammatory, and anti-edema effects. Many studies have been conducted on the 95% ethanol extract of V.
Seon Gyeong Bak +8 more
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Maxillofacial Plastic and Reconstructive Surgery, 2021 Background Nasal sill is one of the components of the alar ring, affecting the esthetic outcomes of rhinoplasty; accordingly, we developed a novel technique to adjust defects in this area and compared it with the available techniques.
Gholamhossein Adham +4 more
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Journal of Functional Biomaterials, 2022 The surface stiffness of the microenvironment is a mechanical signal regulating biofilm growth without the risks associated with the use of bioactive agents.
Annabelle Vigué +12 more
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Pharmaceutical and Biomedical Research, 2022 Background: Plasma protein binding is a key component in drug therapy as it affects the pharmacokinetics and pharmacodynamics of drugs. Objectives: This study aimed to predict the fraction of plasma protein binding.
Affaf Khaouane +2 more
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