Results 151 to 160 of about 420,611 (253)

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

Hitting the Wall in Marathon Running: An Integrative Psychophysiological and Durability-Based Review. [PDF]

J Funct Morphol Kinesiol
Grivas GV, Alkasasbeh WJ, Amawi AT.
europepmc   +1 more source

A Multi‐Structural Radiomic Digital Phenotyping Framework for Deciphering Preclinical Evolution of Degenerative Meniscal Tears

Advanced Science, EarlyView.
Subclinical matrix disruption precedes degenerative meniscal tears across the knee joint. A spatial compartmental radiomics model utilizing 3D‐DESS MRI captures early osteochondral destabilization, accurately predicting incident tears up to four years pre‐collapse. Feature attributions uncover coordinated chondral and osseous alterations, advancing non‐
Shengfa Li, Hao Liu, Yanbin Zhu, Hang Zhang, Qifeng Tao, Wenbo Zhao, Xin Miao, Shanshan Yang, Tianyu Chen, David Hunter, Changhai Ding, Ting Wang, Juan Wang, Wei Chen   +13 more
wiley   +1 more source

Visual, Tomographic, and Biomechanical Outcomes of CAIRS with Accelerated Cross-Linking in Moderate to Advanced Keratoconus: A 6-Month Retrospective Case Series. [PDF]

Clin Ophthalmol
Hashmani N, Hashmani S, Saleem J.
europepmc   +1 more source

Rational Surface Engineering Reduces Advanced Glycation End‐Product Adsorption and Improves Implant Integration

Advanced Science, EarlyView.
Targeted surface chemical modification prevents the accumulation of advanced glycation end products (AGEs) on implant surfaces, attenuates inflammation and fibrosis, effectively restores angiogenic activity, and improves osseointegration under diabetic conditions.
Thien Ngoc Le, Wenhao Chen, Tengxiao Huang, Tien Thanh Nguyen, Markos Negash Alemie, Xuan Duy Do, Giles Best, Jordan Li, Jitraporn Vongsvivut, Vi‐Khanh Truong, Weiwei Li, Yunpeng Zhao, Richard Bright, Krasimir Vasilev   +13 more
wiley   +1 more source

Whey Protein-Polysaccharide Nanocomplexes: Structure-Function Characterization and Bone-Related Outcomes in Ovariectomized Rats. [PDF]

Nutrients
Rojas-Molina JI, Gutiérrez-Cortez E, González-Reza RM, Gomez-Vazquez OM, Correa-Piña B, Hernández-Becerra E, Jiménez-Mendoza D, Rojas-Molina A, Quirino-Barreda C, Quintero-García M.   +9 more
europepmc   +1 more source

Integrated Single‐Cell and Spatial Transcriptomics Reveal Convergence on a Senescence‐Associated B Cell–MIF Signaling Axis in Joint Aging and Osteoarthritis Progression

Advanced Science, EarlyView.
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li, Yi Wang, Yongqing You, Yue Cui, Jiayun Liu, Xingbiao Ma, QiuYu Zhu, Qiang Wu, Zanjing Zhai, Zuyan Lu, Kerong Dai, Ye Sun   +11 more
wiley   +1 more source

Baicalein Attenuates Disuse-Driven Skeletal Senescence in Association with Gut Microbiota Modulation. [PDF]

Molecules
Zhao X, Ren T, Bai W, Wang H, Rahman SU, Deng X, Ru K, Zhang G, Zhang W, Qian A.   +9 more
europepmc   +1 more source

Dynamic Supercooled Crystal–Gels for Ultrafast, Reversible Mechanical Adaptative Materials

Advanced Science, EarlyView.
A dynamic supercooled crystal–gel mimics starfish tissue by storing non‐equilibrium energy in a metastable liquid. A gentle touch triggers templated crystallization, producing a 2596‐fold stiffness increase with negligible volume change. The lattice disintegrates reversibly under humidity or warmth.
Yuesong Lv, Hao Feng, Zhangqin Yang, Jianping Yin, Hanfei Li, Bo Zhou, Yuyang Meng, Yuntong Su, Xinxing Zhang, Xibo Pei   +9 more
wiley   +1 more source

Targeting subchondral osteoporosis in osteoarthritis: biomechanical crosstalk and the therapeutic rationale for inflammatory microenvironment remodeling. [PDF]

Front Immunol
Han M, Han L, Zhang S, Tian L, Luo G, Lin K, Su H, Zhang J, Yang F, He M, Wei Q.   +10 more
europepmc   +1 more source