Results 41 to 50 of about 150,530 (247)

Flesh, Foil, and Authenticity: Reflections on Johann AR Roduit’s “Flesh and Foil”

BioéthiqueOnline, 2017
Johann AR Roduit’s poem, “Flesh and Foil,” raises a number of issues regarding enhancement, especially the need for principles to guide the process of human enhancement.
Gunderson, Martin
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Tensor Methods in Biomedical Image Analysis

Journal of Medical Signals and Sensors
In the past decade, tensors have become increasingly attractive in different aspects of signal and image processing areas. The main reason is the inefficiency of matrices in representing and analyzing multimodal and multidimensional datasets.
Farnaz Sedighin
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Porous carbon nanowire array for surface-enhanced Raman spectroscopy

Nature Communications, 2020
SERS can be unreliable for biomedical use. The authors demonstrate a metal-free nanostructure composed of porous carbon nanowires in an array as a SERS substrate.
Nan Chen, Ting-Hui Xiao, Zhenyi Luo, Yasutaka Kitahama, Kotaro Hiramatsu, Naoki Kishimoto, Tamitake Itoh, Zhenzhou Cheng, Keisuke Goda   +8 more
doaj   +1 more source

Organism–Materials Integration: A Promising Strategy for Biomedical Applications

Advanced NanoBiomed Research, 2021
In nature, organisms play an essential role in harnessing elements to produce materials. Being precisely integrated with the biological structures, the materials confer organisms with various unique functions such as protection, recognition guiding ...
Yihao Cui, Benke Li, Xiaoyu Wang, Ruikang Tang   +3 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Flexible and Wearable Antenna for Biomedical Application: Progress and Opportunity

IEEE Access
In recent years, wearable antenna demand in biomedical applications has increased drastically. Several effective techniques and efficient structures of antenna were proposed to overcome the challenges with respect to the vicinity of the human body.
A. L. Sharon Giftsy, Usha Kiran Kommuri, Ravi Prakash Dwivedi   +2 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source