Results 51 to 60 of about 163,714 (297)

An evaluative conservative case for biomedical enhancement [PDF]

, 2018
It is widely believed that a conservative moral outlook is opposed to biomedical forms of human enhancement. In this paper, I argue that this widespread belief is incorrect.
Danaher, John
core  

A method for improving the clarity of fine details of biomedical images using graph enhancement

Технічна інженерія
Improving the quality of biomedical images is critically important for ensuring reliable visualization of anatomical structures and pathological changes, which directly affects the accuracy of diagnosis.
S.A. Andrikevych, A.V. Shcherbatyuk, S.Y. Tuzhanskyi   +2 more
doaj   +1 more source

The evolution of moral progress and biomedical moral enhancement [PDF]

Bioethics, 2019
AbstractIn The Evolution of Moral Progress Allen Buchanan and Russell Powell advance an evolutionary explanation of moral progress by morality becoming more ‘inclusivist’. We are prepared to accept this explanation as far as it goes, but argue that it fails to explain how morality can become inclusivist in the fuller sense they intend. In fact, it even
Ingmar Persson, Julian Savulescu
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Moral Enhancement [PDF]

, 2008
Opponents of biomedical enhancement often claim that, even if such enhancement would benefit the enhanced, it would harm others. But this objection looks unpersuasive when the enhancement in question is a moral enhancement ?
Douglas, Thomas
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Flesh & Foil

BioéthiqueOnline, 2016
This poem reflects on the possibility of human enhancement. It shows that if enhancements are embraced step-by-step, without any long-term vision, one might get lost along the way.
Roduit, Johann A R
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Flesh, Foil, and Authenticity: Reflections on Johann AR Roduit’s “Flesh and Foil”

BioéthiqueOnline, 2017
Johann AR Roduit’s poem, “Flesh and Foil,” raises a number of issues regarding enhancement, especially the need for principles to guide the process of human enhancement.
Gunderson, Martin
doaj  

Tensor Methods in Biomedical Image Analysis

Journal of Medical Signals and Sensors
In the past decade, tensors have become increasingly attractive in different aspects of signal and image processing areas. The main reason is the inefficiency of matrices in representing and analyzing multimodal and multidimensional datasets.
Farnaz Sedighin
doaj   +1 more source