Results 51 to 60 of about 373,598 (290)

The social experience of uncertainty: a qualitative analysis of emergency department care for suspected pneumonia for the design of decision support

BMC Medical Informatics and Decision Making
Background This study sought to understand the process of clinical decision-making for suspected pneumonia by emergency departments (ED) providers in Veterans Affairs (VA) Medical Centers.
Peter Taber, Charlene Weir, Susan L. Zickmund, Elizabeth Rutter, Jorie Butler, Barbara E. Jones   +5 more
doaj   +1 more source

Image Enhancement and Noise Reduction Using Modified Delay-Multiply-and-Sum Beamformer: Application to Medical Photoacoustic Imaging

, 2018
Photoacoustic imaging (PAI) is an emerging biomedical imaging modality capable of providing both high contrast and high resolution of optical and UltraSound (US) imaging.
Mahloojifar, Ali, Mozaffarzadeh, Moein, Orooji, Mahdi   +2 more
core   +1 more source

Self-enhancement in scientific research: the self-citation bias [PDF]

, 2011
A typical psychology article contains 3 to 9 self-citations, depending on the length of the reference list (10% of all citations). In contrast, cited colleagues rarely receive more than 3 citations.
Brysbaert, Marc, Smyth, Sinead
core   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Flesh & Foil

BioéthiqueOnline, 2016
This poem reflects on the possibility of human enhancement. It shows that if enhancements are embraced step-by-step, without any long-term vision, one might get lost along the way.
Roduit, Johann A R
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Flesh, Foil, and Authenticity: Reflections on Johann AR Roduit’s “Flesh and Foil”

BioéthiqueOnline, 2017
Johann AR Roduit’s poem, “Flesh and Foil,” raises a number of issues regarding enhancement, especially the need for principles to guide the process of human enhancement.
Gunderson, Martin
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

SSA of biomedical signals: A linear invariant systems approach [PDF]

, 2010
Singular spectrum analysis (SSA) is considered from a linear invariant systems perspective. In this terminology, the extracted components are considered as outputs of a linear invariant system which corresponds to finite impulse response (FIR) filters ...
Figueiredo, Nuno, Georgieva, P., Lang, E.W., Santos, I.M., Teixeira, Ana Rita, Tomé, A.M.   +5 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source