Results 51 to 60 of about 162,788 (297)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Ontology-based document representation for biomedical information retrieval [PDF]

, 2007
In the current era of fast sequencing of entire genomes, more data is becoming available for analysis. This data analysis, in turn, leads to an increasing amount of scientfic publications.
Camous, Fabrice
core  

Biomedical Enhancement and Social Development: A Conservative Techno‐Fix [PDF]

, 2016
Allen Buchanan has argued for a linking of the ethics of human enhancement to the ethics of development more generally. The promise of the 'enhancement enterprise' is that it may help develop society, just as other technological advances have in the past.
Sanyal, S, Sagar Sanyal
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The social experience of uncertainty: a qualitative analysis of emergency department care for suspected pneumonia for the design of decision support

BMC Medical Informatics and Decision Making
Background This study sought to understand the process of clinical decision-making for suspected pneumonia by emergency departments (ED) providers in Veterans Affairs (VA) Medical Centers.
Peter Taber, Charlene Weir, Susan L. Zickmund, Elizabeth Rutter, Jorie Butler, Barbara E. Jones   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Flesh & Foil

BioéthiqueOnline, 2016
This poem reflects on the possibility of human enhancement. It shows that if enhancements are embraced step-by-step, without any long-term vision, one might get lost along the way.
Roduit, Johann A R
doaj  

A method for improving the clarity of fine details of biomedical images using graph enhancement

Технічна інженерія
Improving the quality of biomedical images is critically important for ensuring reliable visualization of anatomical structures and pathological changes, which directly affects the accuracy of diagnosis.
S.A. Andrikevych, A.V. Shcherbatyuk, S.Y. Tuzhanskyi   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Flesh, Foil, and Authenticity: Reflections on Johann AR Roduit’s “Flesh and Foil”

BioéthiqueOnline, 2017
Johann AR Roduit’s poem, “Flesh and Foil,” raises a number of issues regarding enhancement, especially the need for principles to guide the process of human enhancement.
Gunderson, Martin
doaj