Results 41 to 50 of about 373,598 (290)

Monte Carlo-based Noise Compensation in Coil Intensity Corrected Endorectal MRI [PDF]

, 2015
Background: Prostate cancer is one of the most common forms of cancer found in males making early diagnosis important. Magnetic resonance imaging (MRI) has been useful in visualizing and localizing tumor candidates and with the use of endorectal coils ...
Haider, Masoom, Lui, Dorothy, Modhafar, Amen, Wong, Alexander   +3 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Clinical translation of biomedical materials and the key factors towards product registration

Journal of Orthopaedic Translation, 2014
Biomedical materials have been developed for facilitating tissue regeneration and healing enhancement. Although research on biomedical materials has made great progress in material innovation and preclinical testing, the bottleneck is their translation ...
Yuan Yuan, Dan Lin, Fangping Chen, Changsheng Liu   +3 more
doaj   +1 more source

Colon adenocarcinoma diagnosis in human samples by multicontrast nonlinear optical microscopy of hematoxylin and eosin stained histological sections [PDF]

, 2014
Combined multimodal nonlinear optical (NLO) microscopies were used to detect and quantify morphological changes associated with stroma and epithelial transformation in colon cancer.
Adur, Javier Fernando, Bianchi, Mariana, Carvalho, Hernandes Faustino, Casco, Victor Hugo, Cesar, Carlos L., Izaguirre, María Fernanda, Pelegati, Vitor B., Viale, Silvia   +7 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Enhancing biomedical relation extraction with directionality

Bioinformatics
Abstract Summary Biological relation networks contain rich information for understanding the biological mechanisms behind the relationship of entities such as genes, proteins, diseases, and chemicals.
Po-Ting Lai, Chih-Hsuan Wei, Shubo Tian, Robert Leaman, Zhiyong Lu   +4 more
openaire   +2 more sources

Privacy-enhancing ETL-processes for biomedical data

International Journal of Medical Informatics, 2019
Modern data-driven approaches to medical research require patient-level information at comprehensive depth and breadth. To create the required big datasets, information from disparate sources can be integrated into clinical and translational warehouses. This is typically implemented with Extract, Transform, Load (ETL) processes, which access, harmonize
Fabian, Prasser, Helmut, Spengler, Raffael, Bild, Johanna, Eicher, Klaus A, Kuhn   +4 more
openaire   +3 more sources

Enhancement attacks in biomedical machine learning

, 2023
12 pages, 3 ...
Rosenblatt, Matthew, Dadashkarimi, Javid, Scheinost, Dustin   +2 more
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source