Results 71 to 80 of about 859,031 (290)

Background-free fibre optic Brillouin probe for remote mapping of micromechanics

, 2020
Brillouin spectroscopy is a century-old technique that has recently received renewed interest, as modern instrumentation has transformed it into a powerful contactless and label-free probe of micromechanical properties for biomedical applications.
Basirun, Carin, Chou, Joshua, Gao, Shoufei, Kabakova, Irina V., Török, Peter, Wang, Yingying, Warkiani, Majid E., Xiang, YuChen   +7 more
core   +1 more source

Noninvasive depth estimation using tissue optical properties and a dual-wavelength fluorescent molecular probe in vivo [PDF]

, 2017
Translation of fluorescence imaging using molecularly targeted imaging agents for real-time assessment of surgical margins in the operating room requires a fast and reliable method to predict tumor depth from planar optical imaging.
Achilefu, Samuel, Lam, Jesse, Maji, Dolonchampa, Miller, Jessica P, Tromberg, Bruce J   +4 more
core   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Deep and optically resolved imaging through scattering media by space-reversed propagation

, 2012
We propose a novel technique of microscopy to overcome the effects of both scattering and limitation of the accessible depth due to the objective working distance.
De Chatellus, Hugues Guillet, Glastre, Wilfried, Hugon, Olivier, Jacquin, Olivier, Lacot, Eric   +4 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Building open lab hardware to tackle antimicrobial resistance [PDF]

Microbiological imaging can be lengthy and labour-intensive without expensive lab-automation. Using Open Source hardware and software, Dr Al Edwards’ Biomedical Technology Lab designed a robot to take high-resolution images of experiments capturing ...
Bull, Stephanie, Edwards, Al, Needs, Sarah   +2 more
core   +1 more source

Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers

Scientific Reports, 2017
Occult bacterial infections represent a worldwide health problem. Differentiating active bacterial infection from sterile inflammation can be difficult using current imaging tools. Present clinically viable methodologies either detect morphologic changes
Kiel D. Neumann, Javier E. Villanueva-Meyer, Christopher A. Mutch, Robert R. Flavell, Joseph E. Blecha, Tiffany Kwak, Renuka Sriram, Henry F. VanBrocklin, Oren S. Rosenberg, Michael A. Ohliger, David M. Wilson   +10 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

In vivo 3D myocardial membrane potential mapping in humans using PET/MRI

EJNMMI Research
Background The mitochondrial membrane potential is a key biophysical parameter of mitochondrial function, which can be useful for the diagnosis and treatment monitoring of various cardiac diseases.
Felicitas J. Bijari, Paul Kyu Han, Thibault Marin, Wonil Lee, Yanis Chemli, Inna Gertsenshteyn, Ismaël B. G. Mounime, Yanis Djebra, Didi Chi, Marc D. Normandin, Chao Ma, Georges El Fakhri   +11 more
doaj   +1 more source