Results 81 to 90 of about 859,031 (290)

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Offline reinforcement learning combining generalized advantage estimation and modality decomposition interaction

Scientific Reports
Transformers show great potential in offline reinforcement learning via trajectory sequence modeling for action prediction. However, existing Transformer-based methods face limitations, such as ineffective trajectory stitching and the neglect of deep ...
Kaixin Jin, Lifang Wang, Xiwen Wang, Wei Guo, Qiang Han, Xiaoqing Yu   +5 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Mapping the microstructure of human cerebral cortex in vivo with diffusion MRI

Communications Biology
Despite advances in diffusion MRI, which have led to remarkable progress in mapping white matter of the living human brain, our understanding of cerebral cortical microstructure in vivo and its relationship to macrostructure, myeloarchitecture ...
Amir Sadikov, Hannah L. Choi, Jaclyn Xiao, Lanya T. Cai, Pratik Mukherjee   +4 more
doaj   +1 more source

Optomechatronics for Biomedical Optical Imaging: An Overview

MATEC Web of Conferences, 2015
The use of optomechatronic technology, particularly in biomedical optical imaging, is becoming pronounced and ever increasing due to its synergistic effect of the integration of optics and mechatronics. The background of this trend is that the biomedical
Cho Hyungsuck
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Unique depot formed by an oil based vaccine facilitates active antigen uptake and provides effective tumour control

Journal of Biomedical Science, 2018
Background Oil emulsions are commonly used as vaccine delivery platforms to facilitate slow release of antigen by forming a depot at the injection site. Antigen is trapped in the aqueous phase and as the emulsion degrades in vivo the antigen is passively
Kimberly D. Brewer, Genevieve M. Weir, Iulia Dude, Christa Davis, Cathryn Parsons, Andrea Penwell, Rajkannan Rajagopalan, Leeladhar Sammatur, Chris V. Bowen, Marianne M. Stanford   +9 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Continuous-Wave THz Imaging for Biomedical Samples

Applied Sciences, 2020
In the past few decades, the applications of terahertz (THz) spectroscopy and imaging technology have seen significant developments in the fields of biology, medical diagnosis, food safety, and nondestructive testing.
Yaya Zhang, Chuting Wang, Bingxin Huai, Shiyu Wang, Yating Zhang, Dayong Wang, Lu Rong, Yongchang Zheng   +7 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source