Results 81 to 90 of about 2,765,310 (254)

Surface-Enhanced Raman Spectroscopy for biomedical diagnostics and imaging [PDF]

, 2013
Surface-enhanced Raman spectroscopy (SERS) is an analytical technique exploiting plasmonic effects that enhance sensitivity significantly, compared to conventional Raman spectroscopy.
Srajer, Johannes, Nowak, Christoph, Schwaighofer, Andreas; orcid:   +2 more
core   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization

Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization is an international journal whose main goals are to promote solutions of excellence for both imaging and visualization of biomedical data, and establish links among ...
SGALLARI, FIORELLA
core   +1 more source

PET/MRI multimodality imaging to evaluate changes in glymphatic system function and biomarkers of Alzheimer’s disease

Scientific Reports
The glymphatic system is considered to play a pivotal role in the clearance of disease-causing proteins in neurodegenerative diseases. This study employed MR diffusion tensor imaging (DTI) to evaluate glymphatic system function and its correlation with ...
Hidehiko Okazawa, Munenobu Nogami, Shota Ishida, Akira Makino, Tetsuya Mori, Yasushi Kiyono, Masamichi Ikawa   +6 more
doaj   +1 more source

Unique depot formed by an oil based vaccine facilitates active antigen uptake and provides effective tumour control

Journal of Biomedical Science, 2018
Background Oil emulsions are commonly used as vaccine delivery platforms to facilitate slow release of antigen by forming a depot at the injection site. Antigen is trapped in the aqueous phase and as the emulsion degrades in vivo the antigen is passively
Kimberly D. Brewer, Genevieve M. Weir, Iulia Dude, Christa Davis, Cathryn Parsons, Andrea Penwell, Rajkannan Rajagopalan, Leeladhar Sammatur, Chris V. Bowen, Marianne M. Stanford   +9 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Prospective deployment of AI-based risk stratification to enable expedited mammography workflow in a safety-net setting

npj Digital Medicine
Delays between screening and diagnostic mammography contribute to disparities in breast cancer outcomes and reduce screening adherence. We prospectively evaluated the operational feasibility and impact of integrating AI risk stratification into screening
Maggie Chung, Eric Davis, Heather Greenwood, Jessica Hayward, Shinn-Huey Shirley Chou, Bonnie Joe, Loretta Strachowski, Tatiana Kelil, Rita Freimanis, Elissa Price, Kimberly Ray, Amie Lee, Adam Yala   +12 more
doaj   +1 more source

Imaging tumour hypoxia with Positron Emission Tomography [PDF]

, 2015
ACKNOWLEDGEMENTS Cancer Research UK (CRUK) funded the National Cancer Research Institute (NCRI) PET Research Working party to organise a meeting to discuss imaging cancer with hypoxia tracers and Positron Emission Tomography. IF was funded by CRUK and is
P J Blower, West, C, Blower, P J, C Baldry, Blower, PJ, Baldry, C, Williams, KJ, S Lord, C West, I N Fleming, Lord, S, Domarkas, J, Harris, A L, Harris, AL, Fleming, I N, West, C; id_orcid, Gilbert, F J, Fleming, IN, A L Harris, Gilbert, FJ., Williams, K J, R Manavaki, F J Gilbert, K J Williams, J Domarkas, Manavaki, R   +25 more
core   +2 more sources

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source