Results 81 to 90 of about 7,364,821 (307)

In-vivo magnetic resonance imaging of hyperpolarized silicon particles

, 2013
Silicon-based micro and nanoparticles have gained popularity in a wide range of biomedical applications due to their biocompatibility and biodegradability in-vivo, as well as a flexible surface chemistry, which allows drug loading, functionalization and ...
Bhattacharya, P. K., Cassidy, M. C., Chan, H. R., Marcus, C. M., Ross, B. D.   +4 more
core   +1 more source

DNP Enhanced Frequency-Selective TEDOR Experiments in Bacteriorhodopsin [PDF]

, 2009
We describe a new approach to multiple [superscript 13]C–[superscript 15]N distance measurements in uniformly labeled solids, frequency-selective (FS) TEDOR. The method shares features with FS-REDOR and ZF- and BASE-TEDOR, which also provide quantitative
Bajaj, Bajaj, Bajaj, Baldus, Barnes, Bayro, Bennett, Delaglio, Goddard, Gullion, Helmus, Herzfeld, Herzfeld, Herzfeld, Herzfeld, Hing, Hornstein, Hu, Hu, Jaroniec, Jaroniec, Jaroniec, Jaroniec, Jaroniec, Jaroniec, Jehle, Judith Herzfeld, Lanyi, Lewandowski, Li, Li, Luecke, Lugtenburg, Mak-Jurkauskas, Marina Belenky, Markley, Mehta, Melody L. Mak-Jurkauskas, Michal, Petkova, Petkova, Rienstra, Robert G. Griffin, Rosay, Song, Stoeckenius, Ulrich, van der Wel, van der Wel, Veshtort, Vikram S. Bajaj, Vuister, Woskov   +52 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Supercontinuum radiation in fluorescence microscopy and biomedical imaging applications

Journal of the Optical Society of America B, 2019
Compact, high brightness supercontinuum sources have already made a big impact in the fields of fluorescence microscopy and biomedical imaging techniques, such as optical coherence tomography and coherent anti-Stokes Raman scattering.
Chetan Poudel, C. Kaminski
semanticscholar   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Mechanisms of dynamic nuclear polarization in insulating solids [PDF]

, 2015
Dynamic nuclear polarization (DNP) is a technique used to enhance signal intensities in NMR experiments by transferring the high polarization of electrons to their surrounding nuclei. The past decade has witnessed a renaissance in the development of DNP,
Can, Thach V, Griffin, Robert Guy, Ni, Qing Zhe   +2 more
core   +1 more source

Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging

Chemical Science, 2018
A review of recent advances in near-infrared II fluorophores for multifunctional biomedical imaging.
Feng Ding, Yibei Zhan, Xiaoju Lu, Yao Sun   +3 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Optomechatronics for Biomedical Optical Imaging: An Overview

MATEC Web of Conferences, 2015
The use of optomechatronic technology, particularly in biomedical optical imaging, is becoming pronounced and ever increasing due to its synergistic effect of the integration of optics and mechatronics. The background of this trend is that the biomedical
Cho Hyungsuck
doaj   +1 more source