Results 61 to 70 of about 1,046,306 (342)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Discrimination between healthy and patients with Parkinson’s disease from hand resting activity using inertial measurement unit

BioMedical Engineering OnLine, 2021
Background Parkinson’s disease (PD) is a neurological disease that affects the motor system. The associated motor symptoms are muscle rigidity or stiffness, bradykinesia, tremors, and gait disturbances.
Luciano Brinck Peres, Bruno Coelho Calil, Ana Paula Sousa Paixão Barroso da Silva, Valdeci Carlos Dionísio, Marcus Fraga Vieira, Adriano de Oliveira Andrade, Adriano Alves Pereira   +6 more
doaj   +1 more source

Cardiovascular risk and work stress in biomedical researchers in China: An observational, big data study protocol [PDF]

arXiv, 2020
Introduction: Internet technologies could strengthen data collection and integration and have been used extensively in public health research. It is necessary to apply this technology to further investigate the behaviour and health of biomedical researchers. A browser-based extension was developed by researchers and clinicians to promote the collection
arxiv  

Noninvasive assessment of inspiratory muscle neuromechanical coupling during inspiratory threshold loading [PDF]

, 2019
Diaphragm neuromechanical coupling (NMC), which reflects the efficiency of conversion of neural activation to transdiaphragmatic pressure (Pdi), is increasingly recognized to be a useful clinical index of diaphragm function and respiratory mechanics in ...
Estrada Petrocelli, Luis Carlos, Jané Campos, Raimon, Jolley, J, Lozano García, Manuel, Moxham, John, Rafferty, Gerrard F., Torres Cebrián, Abel   +6 more
core   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Lack of Diversity in Personal Health Record Evaluations with Older Adult Participants: A Systematic Review of Literature

Journal of Innovation in Health Informatics, 2017
Background: Older adults are not adopting personal health records (PHRs) at the same rates as other adult populations. Disparities in adoption rates are also reported in older adult subgroups.
Laura Kneale, George Demiris
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Number needed to treat (NNT) in clinical literature: an appraisal

BMC Medicine, 2017
Background The number needed to treat (NNT) is an absolute effect measure that has been used to assess beneficial and harmful effects of medical interventions.
Diogo Mendes, Carlos Alves, Francisco Batel-Marques   +2 more
doaj   +1 more source

High-throughput Biomedical Relation Extraction for Semi-Structured Web Articles Empowered by Large Language Models [PDF]

arXiv, 2023
Objective: To develop a high-throughput biomedical relation extraction system that takes advantage of the large language models'(LLMs) reading comprehension ability and biomedical world knowledge in a scalable and evidential manner. Methods: We formulate the relation extraction task as binary classifications for large language models.
arxiv  

A survey of orthopaedic journal editors determining the criteria of manuscript selection for publication [PDF]

, 2011
Background: To investigate the characteristics of editors and criteria used by orthopaedic journal editors in assessing submitted manuscripts.
Donell, Simon T., Higgs, Deborah, Hing, Caroline B., Hooper, Lee, Song, Fujian   +4 more
core   +4 more sources