Results 71 to 80 of about 1,046,306 (342)
Molecular Oncology, EarlyView.TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair +17 more
wiley +1 more source
BMC Medical Education, 2017 Background Improvement of medical content in Biomedical Engineering curricula based on a qualitative assessment process or on a comparison with another high-standard program has been approached by a number of studies. However, the quantitative assessment
Enas Abdulhay +3 more
doaj +1 more source
Occupational therapy for persons with cognitive impairments
GMS German Medical Science, 2023 Background: Damage to the central nervous system can occur in adulthood, for example, due to stroke, trauma, tumours, or chronic diseases. After damage to the central nervous system, cognitive impairments occur in addition to physical limitations ...
Schnell-Inderst, Petra +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
Heterogeneous Graph based Deep Learning for Biomedical Network Link Prediction [PDF]
arXiv, 2021 Multi-scale biomedical knowledge networks are expanding with emerging experimental technologies that generates multi-scale biomedical big data. Link prediction is increasingly used especially in bipartite biomedical networks to identify hidden biological interactions and relationshipts between key entities such as compounds, targets, gene and diseases.
arxiv
The past and future of the AHP in health care decision making [PDF]
, 2011 Objective. Health care decision making is a complex process involving many stakeholders and allowing for multiple decision criteria. The Analytic Hierarchy process (AHP) can support these complex decisions that relate to the application and coverage of ...
Hummel, Marjan, IJzerman, Maarten
core +2 more sources
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
An assessment of the suitability of a Liebau pump in biomedical applications
The Physics of FluidsImpedance pumping and asymmetric pumping are the main mechanisms of the Liebau effect, a type of valveless pumping. The primary objective of this study is to enhance the current understanding of the mechanics and functionality of a Liebau pump.
Joaquín Anatol +6 more
semanticscholar +1 more source
Layer-by-Layer Assembled Nanowire Networks Enable Graph Theoretical Design of Multifunctional Coatings [PDF]
arXiv, 2023 Multifunctional coatings are central for information, biomedical, transportation and energy technologies. These coatings must possess hard-to-attain properties and be scalable, adaptable, and sustainable, which makes layer-by-layer assembly (LBL) of nanomaterials uniquely suitable for these technologies.
arxiv
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source