Results 81 to 90 of about 418,008 (279)

The translational lag narrative in policy discourse in the United States and the European Union: a comparative study

Humanities & Social Sciences Communications, 2021
Whilst basic science rapidly produces new insights into the biological determinants of human health and disease, clinical innovation is often said to lag behind, as it fails to rapidly turn such knowledge into new tools for innovative patient care.
Erik Aarden, Luca Marelli, Alessandro Blasimme   +2 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Anatomical landmark based registration of contrast enhanced T1-weighted MR images [PDF]

, 2010
In many problems involving multiple image analysis, an im- age registration step is required. One such problem appears in brain tumor imaging, where baseline and follow-up image volumes from a tu- mor patient are often to-be compared.
Demir, Ali, Karaman, Kutlay, Unal, Gozde, Ünal, Gözde   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Neural machine translation enhanced with paraphrasing techniques [PDF]

, 2018
Paraphrase generation is the task of given a word sequence generating another word sequence that keeps the same meaning than the original one. Generating new paraphrases can be used to enhance machine translation systems both at training and test phases.
Tubay Álvarez, Brian
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Metabolic dysregulation in Huntington's disease: Neuronal and glial perspectives

Neurobiology of Disease
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutant huntingtin protein with an abnormal CAG/polyQ expansion in the N-terminus of HTT exon 1.
Ching-Pang Chang, Ching-Wen Wu, Yijuang Chern   +2 more
doaj   +1 more source

The severity of developmental dysplasia of the hip does not correlate with the abnormality in pelvic incidence

BMC Musculoskeletal Disorders, 2020
Background The purpose of this study was to investigate the association between the severity of Developmental dysplasia of the hip (DDH) and the abnormality in pelvic incidence (PI). Methods This was a retrospective study analyzing 53 DDH patients and 53
Rongshan Cheng, Muyin Huang, Willem Alexander Kernkamp, Huiwu Li, Zhenan Zhu, Liao Wang, Tsung-Yuan Tsai   +6 more
doaj   +1 more source

A translational framework for public health research [PDF]

, 2009
<p><b>Background</b></p> <p>The paradigm of translational medicine that underpins frameworks such as the Cooksey report on the funding of health research does not adequately reflect the complex reality of the public health ...
A Bradford Hill, A Lyon, A Raffle, A Wakefield, B Lo, Committee of Inquiry into the Future Development of the Public Health Function, D Cooksey, D Dougherty, D Elliman, D Ogilvie, D Ogilvie, D Wanless, David Ogilvie, E Ginexi, F Cappuccio, Foresight, G Duyk, I Chalmers, J Lavis, J Lavis, J Lavis, J Tudor Hart, J Westfall, K Narayan, K Narayan, L Arai, L Bero, M Lean, M Petticrew, M Petticrew, M Petticrew, M Petticrew, M Whitehead, N Cook, N Saeed, N Sung, Nicholas J Wareham, P Alderson, P Blair, P Craig, P Craig, P Wilson, Peter Craig, R Beaglehole, R Gilbert, R Horton, R Pawson, S Cummins, S Hanney, S Hilton, S Innvær, S Kuruvilla, S Sussman, S Woolf, Sally Macintyre, Simon Griffin, T Greenhalgh, T Sheldon   +57 more
core   +3 more sources