Results 41 to 50 of about 253,550 (273)

From Systems Biology to Systems Biomedicine

, 2012
peer reviewedSystems Biology is about combining theory, technology, and targeted experiments in a way that drives not only data accumulation but knowledge as well.
Paul MA Antony, BALLING, Rudi, Rudi Balling, Nikos Vlassis, ANTONY, Paul, VLASSIS, Nikos   +5 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids

Advanced Science, 2020
The comprehensive understanding and proper use of supramolecular interactions have become critical for the development of functional materials, and so is the biomedical application of nucleic acids (NAs).
Fan Xiao, Zhe Chen, Zixiang Wei, Leilei Tian   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

WS54: Human Gene Mapping Workshops c.1973-c.1991 (25-Mar-2014)

, 2017
Selection of photos taken at the Witness Seminar “Human Gene Mapping Workshops c.1973-c.1991” held by the History of Modern Biomedicine Research Group, 25-Mar-2014.

core   +4 more sources

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

, 2012
BIOMEDICINE AND ...
ARCIOLA, CARLA RENATA
core   +1 more source

Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology

Biosensors
Traditional drug development is a long and expensive process with high rates of failure. This has prompted the pharmaceutical industry to seek more efficient drug development frameworks, driving the emergence of organ-on-a-chip (OOC) based on ...
Sheng Yuan, Huipu Yuan, David C. Hay, Huan Hu, Chaochen Wang   +4 more
doaj   +1 more source

Biocatalysis by Transglutaminases: A Review of Biotechnological Applications

Micromachines, 2018
The biocatalytic activity of transglutaminases (TGs) leads to the synthesis of new covalent isopeptide bonds (crosslinks) between peptide-bound glutamine and lysine residues, but also the transamidation of primary amines to glutamine residues, which ...
Maria Pia Savoca, Elisa Tonoli, Adeola G. Atobatele, Elisabetta A. M. Verderio   +3 more
doaj   +1 more source