Results 61 to 70 of about 475,736 (375)

Sweet Taste Preference: Relationships with Other Tastes, Liking for Sugary Foods and Exploratory Genome-Wide Association Analysis in Subjects with Metabolic Syndrome

Biomedicines, 2021
Taste perception and its association with nutrition and related diseases (type 2 diabetes, obesity, metabolic syndrome, cardiovascular, etc.) are emerging fields of biomedicine.
Rebeca Fernández-Carrión, Jose V. Sorlí, Oscar Coltell, Eva C. Pascual, Carolina Ortega-Azorín, Rocío Barragán, Ignacio M. Giménez-Alba, Andrea Alvarez-Sala, Montserrat Fitó, Jose M. Ordovas, Dolores Corella   +10 more
doaj   +1 more source

Evaluation of a novel virtual screening strategy using receptor decoy binding sites [PDF]

, 2016
Virtual screening is used in biomedical research to predict the binding affinity of a large set of small organic molecules to protein receptor targets.
Kukol, A., Kukol, A., Patel, H., Patel, H.   +3 more
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Objets-frontière à l’épreuve

Revue d'anthropologie des connaissances, 2009
This paper analyzes the creation of a research collective around a gene-therapy clinical trial thanks to the concept of boundary-object. It describes the scientific, organizational and regulation dimensions of the trial, and analyzes the different ...
Martin Rémondet
doaj   +1 more source

Six questions on the construction of ontologies in biomedicine [PDF]

, 2005
(Report assembled for the Workshop of the AMIA Working Group on Formal Biomedical Knowledge Representation in connection with AMIA Symposium, Washington DC, 2005.) Best practices in ontology building for biomedicine have been frequently ...
Burgun, A., Ceusters, W., Cimino, J., Davis, J., Elkin, P., Kalet, I., Kumar, Anand, Others, Rector, A., Rice, J., Rogers, J., Smith, Barry   +11 more
core  

Metal Ion Signaling in Biomedicine

Chemical Reviews
Complex multicellular organisms are composed of distinct tissues involving specialized cells that can perform specific functions, making such life forms possible.
Raphaël Rodriguez, Sebastian Müller, Ludovic Colombeau, Stéphanie Solier, Fabien Sindikubwabo, T. Cañeque   +5 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

National Center for Biomedical Ontology: Advancing biomedicine through structured organization of scientific knowledge [PDF]

, 2006
The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow
Chute, Christopher G., Lewis, Suzanna E., Michael, Ashburner, Monte, Westerfield, Mungall, Chris J., Musen, Mark A., Noy, Natasha, Richter, John D., Rubin, Daniel L., Sim, Ida, Sima, Misra, Smith, Barry, Solbrig, Harold, Storey, M. A.   +13 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Intersection of nanomaterials and organoids technology in biomedicine

Frontiers in Immunology, 2023
Organoids are stem cell-derived, self-organizing, 3D structures. Compared to the conventional 2D cell culture method, 3D cultured organoids contain a variety of cell types that can form functional “micro-organs” and can be used to simulate the occurrence
Chen Shen, Zi-jian Zhang, Xiao-xue Li, Yun-peng Huang, Yong-xiang Wang, Hui Zhou, Li Xiong, Yu Wen, Heng Zou, Zhong-tao Liu   +9 more
doaj   +1 more source