Results 121 to 130 of about 185,073 (295)

Enhancing prime editor flexibility with coiled-coil heterodimers

Genome Biology
Background Prime editing enables precise base substitutions, insertions, and deletions at targeted sites without the involvement of double-strand DNA breaks or exogenous donor DNA templates.
Shuangshuang Mu, Huangyao Chen, Qianru Li, Shixue Gou, Xiaoyi Liu, Junwei Wang, Wei Zheng, Menglong Chen, Qin Jin, Liangxue Lai, Kepin Wang, Hui Shi   +11 more
doaj   +1 more source

Evaluating the Impact of Active Footwear Systems on Vascular Health and Static Balance: An Exploratory Study

Sensors
Work-related musculoskeletal disorders are prevalent in occupations requiring prolonged standing and repetitive movements, often leading to vascular issues and reduced static balance. Innovations in wearable technology, such as smart footwear integrating
Susana Lopes, Mário Rodrigues, Mário Lopes, Rui Costa, Joaquim Alvarelhão   +4 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Genome-wide association study and meta-analysis of phytosterols identifies a novel locus for serum levels of campesterol

Human Genomics
Sitosterolemia is a rare inherited disorder caused by mutations in the ABCG5/ABCG8 genes. These genes encode proteins involved in the transport of plant sterols.
Jamil Alenbawi, Yasser A. Al-Sarraj, Umm-Kulthum I. Umlai, Ayat Kadhi, Nagham N. Hendi, Georges Nemer, Omar M. E. Albagha   +6 more
doaj   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

Data analytics based positioning of health informatics programs [PDF]

, 2017
The Master of Science in Computer Information Systems (CIS) with concentration in Health Informatics (HI) at Metropolitan College (MET), Boston University (BU), is a 40-credit degree program that are delivered in three formats: face-to-face, online, and ...
Brusic, Vladimir, Chitkushev, Lou, Zhang, Guanglan   +2 more
core  

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Decision support systems for antibiotic prescription in hospitals: a survey with hospital managers on factors for implementation

BMC Medical Informatics and Decision Making
Background Inappropriate antimicrobial use, such as antibiotic intake in viral infections, incorrect dosing and incorrect dosing cycles, has been shown to be an important determinant of the emergence of antimicrobial resistance.
Pinar Tokgöz, Stephan Krayter, Jessica Hafner, Christoph Dockweiler   +3 more
doaj   +1 more source

Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis

Frontiers in Medicine
Clofazimine (CFZ) and bedaquiline (BDQ) are currently used for the treatment of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) strains.
Md Mahmudul Islam, Md Mahmudul Islam, Md Mahmudul Islam, Md Mahmudul Islam, Md Mahmudul Islam, Md Shah Alam, Md Shah Alam, Md Shah Alam, Md Shah Alam, Zhiyong Liu, Zhiyong Liu, Zhiyong Liu, Zhiyong Liu, Zhiyong Liu, Mst Sumaia Khatun, Mst Sumaia Khatun, Mst Sumaia Khatun, Mst Sumaia Khatun, Buhari Yusuf, Buhari Yusuf, Buhari Yusuf, Buhari Yusuf, H. M. Adnan Hameed, H. M. Adnan Hameed, H. M. Adnan Hameed, H. M. Adnan Hameed, Xirong Tian, Xirong Tian, Xirong Tian, Xirong Tian, Chiranjibi Chhotaray, Rajesh Basnet, Rajesh Basnet, Rajesh Basnet, Rajesh Basnet, Haftay Abraha, Haftay Abraha, Haftay Abraha, Haftay Abraha, Xiaofan Zhang, Xiaofan Zhang, Xiaofan Zhang, Xiaofan Zhang, Shahzad Akbar Khan, Shahzad Akbar Khan, Shahzad Akbar Khan, Shahzad Akbar Khan, Shahzad Akbar Khan, Cuiting Fang, Cuiting Fang, Cuiting Fang, Cuiting Fang, Chunyu Li, Chunyu Li, Chunyu Li, Chunyu Li, Sohel Hasan, Shouyong Tan, Shouyong Tan, Nanshan Zhong, Nanshan Zhong, Nanshan Zhong, Jinxing Hu, Jinxing Hu, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang   +67 more
doaj   +1 more source