Results 111 to 120 of about 185,073 (295)

Deficiency of ASGR1 Alleviates Diet-Induced Systemic Insulin Resistance via Improved Hepatic Insulin Sensitivity [PDF]

Diabetes & Metabolism Journal
Background Insulin resistance (IR) is the key pathological basis of many metabolic disorders. Lack of asialoglycoprotein receptor 1 (ASGR1) decreased the serum lipid levels and reduced the risk of coronary artery disease.
Xiaorui Yu, Jiawang Tao, Yuhang Wu, Yan Chen, Penghui Li, Fan Yang, Miaoxiu Tang, Abdul Sammad, Yu Tao, Yingying Xu, Yin-Xiong Li   +10 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Mining for Methods: A Critical Review of the Theoretical and Methodological Contributions of Feminist Science Scholars for Biomedicine and Public Health Research

Freiburger Zeitschrift für Geschlechterstudien, 2015
This is a critical review of the feminist science scholarship that aims to differentiate various feminist approaches to using the concepts of sex, gender, race and/or ethnicity in biomedicine and public health research. With a focus on the conceptual and methodological contributions of various feminist science scholars, we identify three distinctly ...
Singh, Sarah, Klinge, Ineke
openaire   +2 more sources

Reconstitution of pluripotency from mouse fibroblast through Sall4 overexpression

Nature Communications
Somatic cells can be reprogrammed into pluripotent stem cells (iPSCs) by overexpressing defined transcription factors. Specifically, overexpression of OCT4 alone has been demonstrated to reprogram mouse fibroblasts into iPSCs. However, it remains unclear
Lizhan Xiao, Zifen Huang, Zixuan Wu, Yongzheng Yang, Zhen Zhang, Manish Kumar, Haokaifeng Wu, Huiping Mao, Lihui Lin, Runxia Lin, Jingxian Long, Lihua Zeng, Jing Guo, Rongping Luo, Yi Li, Ping Zhu, Baojian Liao, Luqin Wang, Jing Liu   +18 more
doaj   +1 more source

Selecting Monoclonal Cell Lineages from Somatic Reprogramming Using Robotic-Based Spatial-Restricting Structured Flow

Research
Somatic cell reprogramming generates induced pluripotent stem cells (iPSCs), which serve as a crucial source of seed cells for personalized disease modeling and treatment in regenerative medicine.
Xueping Chen, Ke Fan, Jun Lu, Sheng Zhang, Jianhua Dong, Jisheng Qin, Weihua Fan, Yan Wang, Yiyuan Zhang, Huo Peng, Zhizhong Zhang, Zhiyong Sun, Chunlai Yu, Yucui Xiong, Yan Song, Qingqing Ye, Shiwen Mai, Yuanhua Wang, Qizheng Wang, Fengxiang Zhang, Xiaohui Wen, Tiancheng Zhou, Li Han, Mian Long, Guangjin Pan, Julian F. Burke, Xiao Zhang   +26 more
doaj   +1 more source

Generation of a KCNJ11 homozygous knockout human embryonic stem cell line WAe001-A-12 using CRISPR/Cas9

Stem Cell Research, 2017
The ATP-sensitive potassium channel is an octameric complex, and one of its subunits, namely Kir6.2, is encoded by the KCNJ11 gene. Mutations in KCNJ11 result in hyperinsulinism or diabetes mellitus, associated with abnormal insulin secretion.
Fang Yuan, Dongsheng Guo, Ge Gao, Yanli Liu, Yingying Xu, Yuhang Wu, Fan Yang, Xinrong Ke, Keyu Lai, Liangqing Hong, Yin-xiong Li   +10 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

User and Developer Interaction with Editable and Readable Ontologies [PDF]

, 2017
The process of building ontologies is a difficult task that involves collaboration between ontology developers and domain experts and requires an ongoing interaction between them.
Blfgeh, Aisha, Lord, Phillip
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The New Knowledge Environment: Quality Initiatives in Health Sciences Libraries [PDF]

, 1996
published or submitted for ...
Nagle, Ellen
core