Results 91 to 100 of about 69,606 (254)

Targeted delivery of mRNA to immune cells for in vivo cell therapy

Drug Delivery
Messenger RNA (mRNA) therapeutics have revolutionized biomedicine by enabling direct in vivo programming of immune cells. This strategy bypasses the complex manufacturing and high costs associated with ex vivo cell therapies.
Danyang Wang, Yumin Li, Jinfeng Deng, Mengxin Li, Lin-Ping Wu   +4 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Genealogical Identification and Short Tandem Repeat-Based Verification of Suspected Consanguinity in Mongolian Families

The Application of Clinical Genetics
Altansukh Tsend-Ayush,1 Suvd Tumurbaatar,2 Buyandelger Baatar,3 Erdenetuya Ganbaatar,4 Oyunsuren Davaasuren,5 Byambasuren Dagvajantsan,6 Myagmartseren Dashtseren,7 Tsolmon Unurjargal,8 Khurelbaatar Nyamdavaa,9 Sarantuya Jav,1,2 Battogtokh ...
Tsend-Ayush A, Tumurbaatar S, Baatar B, Ganbaatar E, Davaasuren O, Dagvajantsan B, Dashtseren M, Unurjargal T, Nyamdavaa K, Jav S, Chimeddorj B   +10 more
doaj  

Pseudoscience and bad science in biomedicine: analysis of evidence, health risks, and media dissemination

, 2018
Pseudoscience (false science) and science based on faulty and biased studies (bad science) produce false or uncertain knowledge, with poor or no evidence. Both represent a health risk: pseudoscience-based therapies because they can replace or delay conventional treatments, and low-quality biomedicine because it promotes medical interventions that can ...
openaire   +2 more sources

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Decision support systems for antibiotic prescription in hospitals: a survey with hospital managers on factors for implementation

BMC Medical Informatics and Decision Making
Background Inappropriate antimicrobial use, such as antibiotic intake in viral infections, incorrect dosing and incorrect dosing cycles, has been shown to be an important determinant of the emergence of antimicrobial resistance.
Pinar Tokgöz, Stephan Krayter, Jessica Hafner, Christoph Dockweiler   +3 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

An Explainable Machine Learning Approach to Predict Suicidal Thoughts in University Students: The SMS-ME Project

Human Behavior and Emerging Technologies
The increasing prevalence of suicidal ideation among university students, especially those enrolled in medical and healthcare courses, necessitates innovative approaches for early detection and prevention.
Francesco Prinzi, Giada Tripoli, Nicole Bonaccorso, Eleonora Bongiorno, Marco Daino, Roman Byrtus, Caterina La Cascia, Tiziana Currieri, Giuseppe Maniaci, Ilaria Vella, Elisa Galatà, Giulia Ferrara, Fabio Seminerio, Crocettarachele Sartorio, Alessandra Scaglione, Alessandra Giammanco, Rosa Lo Baido, Maria Rosaria Anna Muscatello, Carmela Mento, Clara Lombardo, Maria Salvina Signorelli, Maria Stella Epifanio, Gaia Albano, Francesco Vitale, Daniele La Barbera, Walter Mazzucco, Claudio Costantino, Diego Quattrone, Salvatore Vitabile, Laura Ferraro   +29 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source