Results 91 to 100 of about 185,073 (295)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Assessing External Peak Physical Demands in Under-19 Years and Professional Male Football

Applied Sciences
This study aimed to compare the external peak physical demands (PDs) of under-19-year-old (U19) and professional male football players according to playing position.
Jaime Rebollo Mejía, Juan Ángel Piñero Madrona, Enrique Alonso-Pérez-Chao, Manuel Barba-Ruíz, Diego Muriarte Solana, Adrián Martín-Castellanos   +5 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

The Future of Scholarly Communication in the Humanities: Adaptation or Transformation? [PDF]

, 2004
The paper suggests that the disaggregation of the core functions of scholarly publication will inevitably change communication in the ...
Johnson, Richard K.
core  

Establishment of computational biology in Greece and Cyprus: Past, present, and future. [PDF]

, 2019
We review the establishment of computational biology in Greece and Cyprus from its inception to date and issue recommendations for future development.
Aivaliotis, Michalis, Angelis, Lefteris, Chanalaris, Anastasios, Chasapi, Anastasia, Iliopoulos, Ioannis, Kappas, Ilias, Karapiperis, Christos, Kyrpides, Nikos C, Ouzounis, Christos A, Pafilis, Evangelos, Panteris, Eleftherios, Promponas, Vasilis J, Topalis, Pantelis, Tsiamis, George, Vizirianakis, Ioannis S, Vlassi, Metaxia   +15 more
core   +1 more source

Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells

Stem Cell Research, 2017
In the field of hematopoietic regeneration, deriving hematopoietic stem cells (HSCs) from pluripotent stem cells with engraftment potential is the central mission.
Xuejia Li, Chengxiang Xia, Tongjie Wang, Lijuan Liu, Qianhao Zhao, Dan Yang, Fangxiao Hu, Mengyun Zhang, Ke Huang, Yang Geng, Yi Zheng, Yuxian Guan, Hongling Wu, Xiaoli Chen, Guangjin Pan, Jiekai Chen, Juan Du, Jinyong Wang   +17 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Genome-wide association study identifies 30 loci associated with bipolar disorder. [PDF]

, 2019
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 × 10-4 in an additional
Abbott, Liam, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D, Anjorin, Adebayo, Antilla, Verneri, Awasthi, Swapnil, Badner, Judith A, Barchas, Jack D, Bass, Nicholas, Bauer, Michael, Belliveau, Richard, Bergen, Sarah E, Boks, Marco P, Boocock, James, Breen, Gerome, Budde, Monika, Bunney, William, Burmeister, Margit, Bybjerg-Grauholm, Jonas, Byerley, William, Byrne, Enda M, Bækvad-Hansen, Marie, Bøen, Erlend, Casas, Miquel, Cerrato, Felecia, Cervantes, Pablo, Chambert, Kimberly, Charney, Alexander W, Chen, Danfeng, Churchhouse, Claire, Clarke, Toni-Kim, Coleman, Jonathan RI, Coryell, William, Craig, David W, Cruceanu, Cristiana, Curtis, David, Czerski, Piotr M, Dale, Anders M, de Jong, Simone, de Leeuw, Christiaan A, Degenhardt, Franziska, Del-Favero, Jurgen, DePaulo, J Raymond, Djurovic, Srdjan, Dobbyn, Amanda L, Dumont, Ashley, Elvsåshagen, Torbjørn, Escott-Price, Valentina, Fan, Chun Chieh, Fischer, Sascha B, Flickinger, Matthew, Foroud, Tatiana M, Forstner, Andreas J, Forty, Liz, Frank, Josef, Fraser, Christine, Freimer, Nelson B, Frisén, Louise, Gade, Katrin, Gage, Diane, Garnham, Julie, Gaspar, Héléna A, Giambartolomei, Claudia, Goldstein, Jaqueline, Gordon, Scott D, Gordon-Smith, Katherine, Green, Elaine K, Green, Melissa J, Greenwood, Tiffany A, Grove, Jakob, Guan, Weihua, Guzman-Parra, José, Hamshere, Marian L, Hautzinger, Martin, Heilbronner, Urs, Herms, Stefan, Hipolito, Maria, Hoffmann, Per, Holland, Dominic, Holmans, Peter A, Huckins, Laura, Jamain, Stéphane, Johnson, Jessica S, Juréus, Anders, Mattheisen, Manuel, McQuillin, Andrew, Pavlides, Jennifer M Whitehead, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Pers, Tune H, Richards, Alexander L, Ripke, Stephan, Stahl, Eli A, Steinberg, Stacy, Trubetskoy, Vassily, Trzaskowski, Maciej, Wang, Yunpeng   +99 more
core  

Construction of a GLI3 compound heterozygous knockout human embryonic stem cell line WAe001-A-20 by CRISPR/Cas9 editing

Stem Cell Research, 2018
The human GLI3 protein has a dual function as a transcriptional activator or repressor of hedgehog signaling, depending on the proteolytic processing forms of GLI3.
Ruzhi Wei, Fang Yuan, Yuhang Wu, Yanli Liu, Kai You, Zhen Yang, Yan Chen, Anteneh Getachew, Ning Wang, Yingying Xu, Yuanqi Zhuang, Fan Yang, Yin-xiong Li   +12 more
doaj   +1 more source