Results 91 to 100 of about 68,738 (254)

Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis

Frontiers in Medicine
Clofazimine (CFZ) and bedaquiline (BDQ) are currently used for the treatment of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) strains.
Md Mahmudul Islam, Md Mahmudul Islam, Md Mahmudul Islam, Md Mahmudul Islam, Md Mahmudul Islam, Md Shah Alam, Md Shah Alam, Md Shah Alam, Md Shah Alam, Zhiyong Liu, Zhiyong Liu, Zhiyong Liu, Zhiyong Liu, Zhiyong Liu, Mst Sumaia Khatun, Mst Sumaia Khatun, Mst Sumaia Khatun, Mst Sumaia Khatun, Buhari Yusuf, Buhari Yusuf, Buhari Yusuf, Buhari Yusuf, H. M. Adnan Hameed, H. M. Adnan Hameed, H. M. Adnan Hameed, H. M. Adnan Hameed, Xirong Tian, Xirong Tian, Xirong Tian, Xirong Tian, Chiranjibi Chhotaray, Rajesh Basnet, Rajesh Basnet, Rajesh Basnet, Rajesh Basnet, Haftay Abraha, Haftay Abraha, Haftay Abraha, Haftay Abraha, Xiaofan Zhang, Xiaofan Zhang, Xiaofan Zhang, Xiaofan Zhang, Shahzad Akbar Khan, Shahzad Akbar Khan, Shahzad Akbar Khan, Shahzad Akbar Khan, Shahzad Akbar Khan, Cuiting Fang, Cuiting Fang, Cuiting Fang, Cuiting Fang, Chunyu Li, Chunyu Li, Chunyu Li, Chunyu Li, Sohel Hasan, Shouyong Tan, Shouyong Tan, Nanshan Zhong, Nanshan Zhong, Nanshan Zhong, Jinxing Hu, Jinxing Hu, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang, Tianyu Zhang   +67 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Decision support systems for antibiotic prescription in hospitals: a survey with hospital managers on factors for implementation

BMC Medical Informatics and Decision Making
Background Inappropriate antimicrobial use, such as antibiotic intake in viral infections, incorrect dosing and incorrect dosing cycles, has been shown to be an important determinant of the emergence of antimicrobial resistance.
Pinar Tokgöz, Stephan Krayter, Jessica Hafner, Christoph Dockweiler   +3 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Pseudoscience and bad science in biomedicine: analysis of evidence, health risks, and media dissemination

, 2018
Pseudoscience (false science) and science based on faulty and biased studies (bad science) produce false or uncertain knowledge, with poor or no evidence. Both represent a health risk: pseudoscience-based therapies because they can replace or delay conventional treatments, and low-quality biomedicine because it promotes medical interventions that can ...
openaire   +2 more sources

Mining for Methods: A Critical Review of the Theoretical and Methodological Contributions of Feminist Science Scholars for Biomedicine and Public Health Research

Freiburger Zeitschrift für Geschlechterstudien, 2015
This is a critical review of the feminist science scholarship that aims to differentiate various feminist approaches to using the concepts of sex, gender, race and/or ethnicity in biomedicine and public health research. With a focus on the conceptual and methodological contributions of various feminist science scholars, we identify three distinctly ...
Singh, Sarah, Klinge, Ineke
openaire   +2 more sources

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells

Nature Communications
Ribosome biogenesis plays a pivotal role in maintaining stem cell homeostasis, yet the precise regulatory mechanisms governing this process in mouse embryonic stem cells (mESCs) remain largely unknown.
Xiuqin Wang, Gongcheng Hu, Lisha Wang, Yuli Lu, Yanjiang Liu, Shengxiong Yang, Junzhi Liao, Qian Zhao, Qiuling Huang, Wentao Wang, Wenjing Guo, Heying Li, Yu Fu, Yawei Song, Qingqing Cai, Xiaofei Zhang, Xiangting Wang, Yue-Qin Chen, Xiaorong Zhang, Hongjie Yao   +19 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source