Results 71 to 80 of about 185,073 (295)

The burden of chronic pain and the role of neurorehabilitation: consensus matters where evidence is lacking

Journal of Pain Research, 2017
Stefano Tamburin,1 Stefano Paolucci,2 Nicola Smania,1,3 Giorgio Sandrini4,51Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, 2Santa Lucia Foundation, IRCCS, Rome, 3Neuromotor and Cognitive Rehabilitation ...
Tamburin S, Paolucci S, Smania N, Sandrini G   +3 more
doaj  

Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade

Journal of Virology
Mast cells (MCs) are strategically located at the interface between host and environment. The non-allergic functions of MCs in immunosurveillance against pathogens have been recently underscored.
Shuang Zhang, Chu-Lan Xu, Jingjing Wang, Xiaoli Xiong, Jian-Hua Wang   +4 more
doaj   +1 more source

PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis

Nature Communications, 2021
The polycomb repressive complex 2 (PRC2) is a histone methyltransferase regulating cell differentiation and identity. Here, the authors show that the vertebrate-specific PRC2 accessory subunit PALI1 facilitates substrate binding by the complex and ...
Qi Zhang, Samuel C. Agius, Sarena F. Flanigan, Michael Uckelmann, Vitalina Levina, Brady M. Owen, Chen Davidovich   +6 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

GOVERNANCE OF HIGHER EDUCATION IN INDIAN SYSTEMS OF MEDICINE:\ud ISSUES, CONCERNS, AND CHALLENGES [PDF]

, 2010
This article tries to identify the major issues, concerns and challenges pertaining to higher education in Indian systems of medicine (Ayurveda, Siddha and Unani) in the context of current global ...
Patwardhan, Dr. Kishor
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Is China Systematically Buying Up Key Technologies? Chinese M & A transactions in Germany in the context of “Made in China 2025”. Bertelsmann Stiftung GED Study 2018 [PDF]

, 2018
“Made in China 2025” (MIC 2025) is the Chinese central government’s main industrial policy strategy aimed at turning China into the global leader of the fourth industrial revolution.
Jungbluth, Cora
core  

Health professionals prepared for the future. Why Social Sciences and Humanities teaching in Medical Faculties matter

MedEdPublish, 2018
A public debate took place place in France in 2018 concerning ethical and social issues of biomedicine and life science and technologies. As faculty members of French medical schools and scholars in Social Sciences and Humanities, we contributed to ...
Nicolas Lechopier, Gilles Moutot, Céline Lefève, Maria Teixeira, Roberto Poma, Guillaume Grandazzi, Anne Rasmussen   +6 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

[Where Descartes got it right: the implications for science, biomedicine, and public health].

Cadernos de saude publica, 2017
The "received view" of Descartes has shaped the image of a dualist thinker who radically separated mind and body and thus laid the foundations for a "divided modernity". Numerous epithets have been applied to Cartesian thinking, all of which now sound depreciative: mechanicism, determinism, and reductionism, among others.
André Luis de Oliveira, Mendonça, Kenneth Rochel de, Camargo   +1 more
openaire   +1 more source