Results 81 to 90 of about 69,606 (254)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Selecting Monoclonal Cell Lineages from Somatic Reprogramming Using Robotic-Based Spatial-Restricting Structured Flow

Research
Somatic cell reprogramming generates induced pluripotent stem cells (iPSCs), which serve as a crucial source of seed cells for personalized disease modeling and treatment in regenerative medicine.
Xueping Chen, Ke Fan, Jun Lu, Sheng Zhang, Jianhua Dong, Jisheng Qin, Weihua Fan, Yan Wang, Yiyuan Zhang, Huo Peng, Zhizhong Zhang, Zhiyong Sun, Chunlai Yu, Yucui Xiong, Yan Song, Qingqing Ye, Shiwen Mai, Yuanhua Wang, Qizheng Wang, Fengxiang Zhang, Xiaohui Wen, Tiancheng Zhou, Li Han, Mian Long, Guangjin Pan, Julian F. Burke, Xiao Zhang   +26 more
doaj   +1 more source

Mining for Methods: A Critical Review of the Theoretical and Methodological Contributions of Feminist Science Scholars for Biomedicine and Public Health Research

Freiburger Zeitschrift für Geschlechterstudien, 2015
This is a critical review of the feminist science scholarship that aims to differentiate various feminist approaches to using the concepts of sex, gender, race and/or ethnicity in biomedicine and public health research. With a focus on the conceptual and methodological contributions of various feminist science scholars, we identify three distinctly ...
Singh, Sarah, Klinge, Ineke
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Enhancing prime editor flexibility with coiled-coil heterodimers

Genome Biology
Background Prime editing enables precise base substitutions, insertions, and deletions at targeted sites without the involvement of double-strand DNA breaks or exogenous donor DNA templates.
Shuangshuang Mu, Huangyao Chen, Qianru Li, Shixue Gou, Xiaoyi Liu, Junwei Wang, Wei Zheng, Menglong Chen, Qin Jin, Liangxue Lai, Kepin Wang, Hui Shi   +11 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Genome-wide association study and meta-analysis of phytosterols identifies a novel locus for serum levels of campesterol

Human Genomics
Sitosterolemia is a rare inherited disorder caused by mutations in the ABCG5/ABCG8 genes. These genes encode proteins involved in the transport of plant sterols.
Jamil Alenbawi, Yasser A. Al-Sarraj, Umm-Kulthum I. Umlai, Ayat Kadhi, Nagham N. Hendi, Georges Nemer, Omar M. E. Albagha   +6 more
doaj   +1 more source

Evaluating the Impact of Active Footwear Systems on Vascular Health and Static Balance: An Exploratory Study

Sensors
Work-related musculoskeletal disorders are prevalent in occupations requiring prolonged standing and repetitive movements, often leading to vascular issues and reduced static balance. Innovations in wearable technology, such as smart footwear integrating
Susana Lopes, Mário Rodrigues, Mário Lopes, Rui Costa, Joaquim Alvarelhão   +4 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source