Results 101 to 110 of about 185,073 (295)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Differences in physical activities and nutrition of biomedicine and health students in compare of students from other science field of University Rijeka [PDF]

, 2023
The aim of the article is to determine the differences between physical activities and nutrition between students of biomedical and health sciences and students from other scientific fields at the University of Rijeka. The study included 1170 bachelor and master students of the University of Rijeka enrolled in the academic year 2017/18, from all ...
openaire  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

EUROPEAN STANDARDS FOR PHD EDUCATION IN BIOMEDICINE AND HEALTH SCIENCES (ORPHEUS ACTIVITIES 2004-2009)

, 2009
Since 2004 activities of ORPHEUS were directed toward harmonisation and building of standards for PhD Education in Europe. Participation of 72 health/medical schools from 33 European countries in the last conference in Aarhus 2009 demonstrate wide acceptance of this European organisation.
Lackovic, Zdravko, Mulvany, Michael
openaire   +2 more sources

One hundred years of Ecuadorian biomedical scientific output and its association with the main causes of mortality: a bibliometric study

Frontiers in Medicine
IntroductionHistorically, low-and middle-income countries have been scarce producers of biomedical research; only 2% of the global scientific output is produced by these countries despite accounting for 92% of the global burden of disease.
Ivan Sisa, Jhon Caicedo-Potosí, María Cordovez, Clara Verdezoto, Mishell Barreno, Martín Coral, Gricelda Herrera-Franco   +6 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

PhD program: Biomedicine and Health Sciences at University of Zagreb Medical School [PDF]

, 2004
PhD Programme "Biomedicine and Health Sciences" running at University of Zagreb Medical School is described. It started in academic year 1997/98 as a master’ s degree study but was intended from the start to lead to PhD. After Croatia has officially joined the Bologna process promoting greater harmonization among Europe's diverse systems of ...
openaire   +1 more source

Optimal SpCas9- and SaCas9-mediated gene editing by enhancing gRNA transcript levels through scaffold poly-T tract reduction

BMC Genomics
Ensuring sufficient gRNA transcript levels is critical for obtaining optimal CRISPR-Cas9 gene editing efficiency. The standard gRNA scaffold contains a sequence of four thymine nucleotides (4T), which is known to inhibit transcription from Pol III ...
Yu C. J. Chey, Luke Gierus, Caleb Lushington, Jayshen C. Arudkumar, Ashleigh B. Geiger, Lachlan G. Staker, Louise J. Robertson, Chandran Pfitzner, Jesse G. Kennedy, Ryan H. B. Lee, Gelshan I. Godahewa, Fatwa Adikusuma, Paul Q. Thomas   +12 more
doaj   +1 more source