Results 181 to 190 of about 10,366 (238)

Identifying Subcellular Structure Components in Escherichia Coli by Crosslinking and SEC‐MS

PROTEOMICS, Volume 26, Issue 5, Page 27-36, May 2026.
ABSTRACT Cells are comprised of a broad spectrum of structures that compartmentalize biochemical and signaling mechanisms. These structures can be comprised of many biomolecules, but especially lipids, proteins, and nucleic acids. Techniques are limited to quantify or discover new subcellular structures.
Rachel A. Victor, Austin Lipinski, Paul R. Langlais, Jacob C. Schwartz   +3 more
wiley   +1 more source

Biomolecular Condensates Can Induce Local Membrane Potentials. [PDF]

Small
Gurunian A, Lasker K, Deniz AA.
europepmc   +1 more source

The master molecule that built biology: How water shaped the chemistry of life

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The deep entanglement of biomolecular structure and function with aqueous systems supports the view that water actively sculpted both molecules and processes during the origins of life and continues to constrain evolution today. Nature's rules of biochemistry and biophysics have survived for nearly 4 billion years.
Juliana DiGiacomo, George D. Rose, Loren Dean Williams   +2 more
wiley   +1 more source

Biomolecular Condensates in Disease: Decoding the Material State and Engineering Precision Modulators. [PDF]

Int J Mol Sci
Han B, Li B, Wang X, Wang L.
europepmc   +1 more source

An ALS‐associated mutation in the C‐terminal α‐helix of TDP‐43 uncouples condensate formation and amyloid assembly

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TAR DNA‐binding protein 43 (TDP‐43) plays a critical role in RNA metabolism and is incorporated into biomolecular condensates called stress granules. In amyotrophic lateral sclerosis (ALS) and several other neurodegenerative disorders, TDP‐43 undergoes aberrant phase transitions, forming insoluble amyloid aggregates, including fibrils composed
Emily J. Byrd, Joel A. Crossley, Chalmers C. C. Chau, Paolo Actis, Antonio N. Calabrese   +4 more
wiley   +1 more source

Multiplexed Analysis of Multicomponent Biomolecular Condensates without Any Tag. [PDF]

J Am Chem Soc
Pálfy G, Schmoll J, Pérez ME, Damberger FF, Han Y, Emmanouilidis L, Allain FH, Novakovic M.   +7 more
europepmc   +1 more source

A composition‐matching algorithm, MatchIDR, identifies prion‐like domains that localize to stress granules

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Intrinsically disordered regions (IDRs) play important molecular roles in cells even though they do not adopt a stable structure. Relative to structured regions, IDRs have skewed amino acid compositions favoring polar and charged amino acids. This feature is a major contributor to the biophysical behavior and in vivo activity of IDRs, but the ...
Sean M. Cascarina, Kacy R. Paul, Larissa L. Ford, Eric D. Ross   +3 more
wiley   +1 more source

The Role of Chemistry Across Disciplines From Humanities to Life Sciences in Understanding Complexity and Emergence

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe, Josef Wachtveitl, Alexander Heckel, Florian Buhr, Sabrina Toews, Thomas M. Schimmer   +5 more
wiley   +2 more sources

Protein aggregates and biomolecular condensates: implications for human health and disease. [PDF]

Front Mol Biosci
Navalkar A, Arunagiri A, Kee T, Panchal K, Dick K.   +4 more
europepmc   +1 more source

Transmembrane Condensation in Albumin‐Loaded Giant Vesicles Induced by an Intrinsically Disordered Protein

ChemSystemsChem, Volume 8, Issue 3, May 2026.
An intrinsically disordered protein, Q20, forms transmembrane condensates with albumin‐loaded lipid and hybrid giant vesicles. Condensate insertion and membrane remodeling depend on giant vesicle size and membrane properties, inducing local lipid coupling without leakage and revealing a robust membrane‐condensate interplay.
Paula De Dios Andres, Ankush Garg, Ramy Alam, Isabella N. Westensee, Magnus Kjaergaard, Brigitte Städler   +5 more
wiley   +1 more source