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Extreme dynamics in a biomolecular condensate
Nature, 2023Proteins and nucleic acids can phase-separate in the cell to form concentrated biomolecular condensates$^{1-4}$. The functions of condensates span many length scales: they modulate interactions and chemical reactions at the molecular scale$^{5}$, organize biochemical processes at the mesoscale$^{6}$ and compartmentalize cells$^{4}$.
Galvanetto, Nicola +7 more
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Transcription Regulation by Biomolecular Condensates
Nature Reviews Molecular Cell BiologyBiomolecular condensates regulate transcription by dynamically compartmentalizing the transcription machinery. Classic models of transcription regulation focus on the recruitment and regulation of RNA polymerase II by the formation of complexes at the 1-10 nm length scale, which are driven by structured and stoichiometric interactions.
Pilong LI +2 more
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Dissecting the complexity of biomolecular condensates
Biochemical Society Transactions, 2020Biomolecular condensates comprise a diverse and ubiquitous class of membraneless organelles. Condensate assembly is often described by liquid–liquid phase separation. While this process explains many key features, it cannot account for the compositional or architectural complexity that condensates display in cells.
Pinaki Swain, Stephanie C. Weber
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Biomolecular condensates in photosynthesis and metabolism
Current Opinion in Plant Biology, 2020The transient assembly or sequestration of enzymes into clusters permits the channeling of metabolites, but requires spatiotemporal control. Liquid liquid phase separation (LLPS) has recently emerged as a fundamental concept enabling formation of such assemblies into non-membrane bound organelles.
Wunder, Tobias, Mueller-Cajar, Oliver
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Peptide diffusion in biomolecular condensates
Biophysical JournalDiffusion determines the turnover of biomolecules in liquid-liquid phase-separated condensates. We considered the mean square displacement and thus the diffusion constant for simple model systems of peptides GGGGG, GGQGG, and GGVGG in aqueous solutions after phase separation by simulating atomic-level models.
Riley J. Workman +3 more
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Biomolecular condensates and disease pathogenesis
Science China Life SciencesBiomolecular condensates or membraneless organelles (MLOs) formed by liquid-liquid phase separation (LLPS) divide intracellular spaces into discrete compartments for specific functions. Dysregulation of LLPS or aberrant phase transition that disturbs the formation or material states of MLOs is closely correlated with neurodegeneration, tumorigenesis ...
Ke, Ruan +13 more
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Mechanical Remodeling of Nuclear Biomolecular Condensates
PhysiologyOrganism health relies on cell proliferation, migration, and differentiation. These universal processes depend on cytoplasmic reorganization driven notably by the cytoskeleton and its force-generating motors. Their activity generates forces that mechanically agitate the cell nucleus and its interior.
Giulia Soggia +3 more
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Frontiers in biomolecular condensate research
Nature Cell Biology, 2023Mayr, C. +5 more
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Biomolecular Condensates at the Nexus of Cellular Stress, Protein Aggregation Disease and Ageing
Nature Reviews Molecular Cell Biology, 2021Anthony Hyman, Simon Alberti
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