Biomolecular condensate drives polymerization and bundling of the bacterial tubulin FtsZ to regulate cell division [PDF]
Nature Communications, 2023 Cell division is spatiotemporally precisely regulated, but the underlying mechanisms are incompletely understood. In the social bacterium Myxococcus xanthus, the PomX/PomY/PomZ proteins form a single megadalton-sized complex that directly positions and ...
Beatrice Ramm +7 more
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Comparison of Biomolecular Condensate Localization and Protein Phase Separation Predictors [PDF]
Biomolecules, 2023 Research in the field of biochemistry and cellular biology has entered a new phase due to the discovery of phase separation driving the formation of biomolecular condensates, or membraneless organelles, in cells.
Erich R. Kuechler +4 more
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Overexpression of the microtubule-binding protein CLIP-170 induces a +TIP network superstructure consistent with a biomolecular condensate. [PDF]
PLoS ONE, 2021 Proper regulation of microtubule (MT) dynamics is critical for cellular processes including cell division and intracellular transport. Plus-end tracking proteins (+TIPs) dynamically track growing MTs and play a key role in MT regulation.
Yueh-Fu O Wu +5 more
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An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates [PDF]
Cell Reports, 2023 Summary: Biomolecular condensates are implicated in core cellular processes such as gene regulation and ribosome biogenesis. Although the architecture of biomolecular condensates is thought to rely on collective interactions between many components, it ...
Nima Jaberi-Lashkari +3 more
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Mechano-Dependent Sorbitol Accumulation Supports Biomolecular Condensate [PDF]
CellInternational audienceCondensed droplets of protein regulate many cellular functions, yet the physiological conditions regulating their formation remain largely unexplored.
Thomas Bertero
exaly +3 more sources
Macromolecular Crowding Is Surprisingly Unable to Deform the Structure of a Model Biomolecular Condensate [PDF]
Biology, 2023 The crowded interior of a living cell makes performing experiments on simpler in vitro systems attractive. Although these reveal interesting phenomena, their biological relevance can be questionable.
Julian C. Shillcock +3 more
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Cell Reports, 2023 Summary: Membraneless organelles, or biomolecular condensates, enable cells to compartmentalize material and processes into unique biochemical environments. While specific, attractive molecular interactions are known to stabilize biomolecular condensates,
Michael D. Crabtree +11 more
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BRD4-targeting PROTAC as a unique tool to study biomolecular condensates
Cell Discovery, 2023 Biomolecular condensates play key roles in various biological processes. However, specific condensation modulators are currently lacking. PROTAC is a new technology that can use small molecules to degrade target proteins specifically.
Yi Shi +8 more
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Biomolecules, 2021 Biomolecular condensates, which assemble via the process of liquid–liquid phase separation (LLPS), are multicomponent compartments found ubiquitously inside cells.
Ignacio Sanchez-Burgos +3 more
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Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders
Antioxidants, 2021 Biomolecular condensates are membraneless organelles (MLOs) that form dynamic, chemically distinct subcellular compartments organizing macromolecules such as proteins, RNA, and DNA in unicellular prokaryotic bacteria and complex eukaryotic cells ...
Doris Loh, Russel J. Reiter
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