Comparison of Biomolecular Condensate Localization and Protein Phase Separation Predictors [PDF]
Biomolecules, 2023 Research in the field of biochemistry and cellular biology has entered a new phase due to the discovery of phase separation driving the formation of biomolecular condensates, or membraneless organelles, in cells.
Erich R. Kuechler +4 more
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Biomolecular condensate drives polymerization and bundling of the bacterial tubulin FtsZ to regulate cell division [PDF]
Nature Communications, 2023 Cell division is spatiotemporally precisely regulated, but the underlying mechanisms are incompletely understood. In the social bacterium Myxococcus xanthus, the PomX/PomY/PomZ proteins form a single megadalton-sized complex that directly positions and ...
Beatrice Ramm +7 more
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Overexpression of the microtubule-binding protein CLIP-170 induces a +TIP network superstructure consistent with a biomolecular condensate. [PDF]
PLoS ONE, 2021 Proper regulation of microtubule (MT) dynamics is critical for cellular processes including cell division and intracellular transport. Plus-end tracking proteins (+TIPs) dynamically track growing MTs and play a key role in MT regulation.
Yueh-Fu O Wu +5 more
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Macromolecular Crowding Is Surprisingly Unable to Deform the Structure of a Model Biomolecular Condensate [PDF]
Biology, 2023 The crowded interior of a living cell makes performing experiments on simpler in vitro systems attractive. Although these reveal interesting phenomena, their biological relevance can be questionable.
Julian C. Shillcock +3 more
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The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. [PDF]
Nat Cell Biol, 2019 The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can ...
Trivedi P +5 more
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Decoding biomolecular condensate dynamics: an energy landscape approach. [PDF]
PLoS Computational BiologyMany eukaryotic proteins and RNAs contain low-complexity domains (LCDs) with a strong propensity for binding and driving phase separation into biomolecular condensates.
Subhadip Biswas, Davit A Potoyan
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Extreme dynamics in a biomolecular condensate. [PDF]
Nature, 2023 Two highly charged disordered human proteins phase-separate into viscous complex coacervates while retaining their rapid conformational dynamics through pico- to nanosecond exchange of short-lived side-chain interactions.
Galvanetto N +7 more
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In Vitro Transcription-Translation in an Artificial Biomolecular Condensate. [PDF]
ACS Synth Biol, 2023 Biomolecular condensates are a promising platform for synthetic cell formation and constitute a potential missing link between the chemical and cellular stage of the origins of life.
Schoenmakers LLJ +6 more
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An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates [PDF]
Cell Reports, 2023 Summary: Biomolecular condensates are implicated in core cellular processes such as gene regulation and ribosome biogenesis. Although the architecture of biomolecular condensates is thought to rely on collective interactions between many components, it ...
Nima Jaberi-Lashkari +3 more
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Multivalency Controls the Growth and Dynamics of a Biomolecular Condensate. [PDF]
J Am Chem SocBiomolecular condensates are essential for cellular organization and function, yet understanding how chemical and physical factors govern their formation and dynamics has been limited by a lack of non-invasive measurement techniques.
von Hofe J +7 more
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