Topography-driven movement of biomolecular condensates. [PDF]
PLoS ONEBiomolecular condensates are assemblies of proteins or nucleic acids that exhibit liquid-like properties and organize intracellular biochemical reactions within many cells.
Matthias Pöllmann, Katja Zieske
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Biomolecular Condensates: Formation Mechanisms, Biological Functions, and Therapeutic Targets
MedComm, 2023 Biomolecular condensates are cellular structures composed of membraneless assemblies comprising proteins or nucleic acids. The formation of these condensates requires components to change from a state of solubility separation from the surrounding ...
Long Zhang, Fangfang Zhou, Xin Niu
exaly +3 more sources
Emerging Roles of Ubiquitination in Biomolecular Condensates
Cells, 2023 Biomolecular condensates are dynamic non-membrane-bound macromolecular high-order assemblies that participate in a growing list of cellular processes, such as transcription, the cell cycle, etc.
Peigang Liang, Jiaqi Zhang, Bo Wang
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Landscape of biomolecular condensates in heat stress responses
Frontiers in Plant Science, 2022 High temperature is one of the abiotic stresses that plants face and acts as a major constraint on crop production and food security. Plants have evolved several mechanisms to overcome challenging environments and respond to internal and external stimuli.
Violeta Londoño Vélez +5 more
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BRD4-targeting PROTAC as a unique tool to study biomolecular condensates
Cell Discovery, 2023 Biomolecular condensates play key roles in various biological processes. However, specific condensation modulators are currently lacking. PROTAC is a new technology that can use small molecules to degrade target proteins specifically.
Yi Shi +8 more
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Sequence variations of phase-separating proteins and resources for studying biomolecular condensates
Acta Biochimica et Biophysica Sinica, 2023 Phase separation (PS) is an important mechanism underlying the formation of biomolecular condensates. Physiological condensates are associated with numerous biological processes, such as transcription, immunity, signaling, and synaptic transmission ...
Guo Gaigai +3 more
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Biomolecular condensates as dynamic regulators of musculoskeletal homeostasis, disease, and therapeutic challenges [PDF]
Bone ResearchBiomolecular condensates are membraneless assemblies that concentrate proteins, nucleic acids, and other biomolecules into dynamic cellular compartments.
Qichen Miao +5 more
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Indissoluble biomolecular condensates via elasticity
Physical Review Research, 2023 While biomolecular condensates are often liquidlike, many experiments found that condensates also exhibit solidlike behaviors, making them indissoluble in conditions liquid condensates dissolve.
Lingyu Meng, Jie Lin
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Diverse roles of biomolecular condensation in eukaryotic translational regulation
RNA Biology, 2023 Biomolecular condensates, forming membrane-less organelles, orchestrate the sub-cellular compartment to execute designated biological processes.
Yuhan Zhang +3 more
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Neuronal biomolecular condensates and their implications in neurodegenerative diseases
Frontiers in Aging Neuroscience, 2023 Biomolecular condensates are subcellular organizations where functionally related proteins and nucleic acids are assembled through liquid–liquid phase separation, allowing them to develop on a larger scale without a membrane.
Jeongyeon Nam, Youngdae Gwon
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