Topography-driven movement of biomolecular condensates. [PDF]
PLoS ONEBiomolecular condensates are assemblies of proteins or nucleic acids that exhibit liquid-like properties and organize intracellular biochemical reactions within many cells.
Matthias Pöllmann, Katja Zieske
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Sequence determinants of in cell condensate morphology, dynamics, and oligomerization as measured by number and brightness analysis [PDF]
Cell Communication and Signaling, 2021 Background Biomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization.
Ryan J. Emenecker +2 more
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Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets [PDF]
Molecular BiomedicineCells constantly encounter environmental and physiological fluctuations that challenge homeostasis and threaten viability. In response to these cues, specific proteins and nucleic acids engage in multivalent interactions and undergo phase separation to ...
Sunkyung Choi, Jung-Min Lee, Kee K. Kim
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Oxygen depletion in biomolecular condensates is dominated by macromolecular density [PDF]
Nature CommunicationsBiomolecular condensates are dynamic cellular compartments formed by the self-assembly of proteins and nucleic acids. Many metabolites partition into condensates based on their interactions with the macromolecular constituents; yet, whether gases behave ...
Ankush Garg +4 more
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Do biomolecular condensates regulate the transcriptional and post-transcriptional responses of plant roots to water deficit? [PDF]
Quantitative Plant BiologyWater deficit at the plant cell level can be assimilated to a reduction in turgor pressure and an increase in osmotic pressure. In a previous work, we showed that the mRNA abundance of some genes displays a quantitative relationship to these ...
Coralie Masson +4 more
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Landscape of biomolecular condensates in heat stress responses
Frontiers in Plant Science, 2022 High temperature is one of the abiotic stresses that plants face and acts as a major constraint on crop production and food security. Plants have evolved several mechanisms to overcome challenging environments and respond to internal and external stimuli.
Violeta Londoño Vélez +5 more
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Indissoluble biomolecular condensates via elasticity
Physical Review Research, 2023 While biomolecular condensates are often liquidlike, many experiments found that condensates also exhibit solidlike behaviors, making them indissoluble in conditions liquid condensates dissolve.
Lingyu Meng, Jie Lin
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Diverse roles of biomolecular condensation in eukaryotic translational regulation
RNA Biology, 2023 Biomolecular condensates, forming membrane-less organelles, orchestrate the sub-cellular compartment to execute designated biological processes.
Yuhan Zhang +3 more
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Neuronal biomolecular condensates and their implications in neurodegenerative diseases
Frontiers in Aging Neuroscience, 2023 Biomolecular condensates are subcellular organizations where functionally related proteins and nucleic acids are assembled through liquid–liquid phase separation, allowing them to develop on a larger scale without a membrane.
Jeongyeon Nam, Youngdae Gwon
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Emerging Roles of Ubiquitination in Biomolecular Condensates
Cells, 2023 Biomolecular condensates are dynamic non-membrane-bound macromolecular high-order assemblies that participate in a growing list of cellular processes, such as transcription, the cell cycle, etc.
Peigang Liang, Jiaqi Zhang, Bo Wang
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