Results 11 to 20 of about 10,366 (238)

Biomolecular condensates: Formation mechanisms, biological functions, and therapeutic targets

MedComm, 2023
Biomolecular condensates are cellular structures composed of membraneless assemblies comprising proteins or nucleic acids. The formation of these condensates requires components to change from a state of solubility separation from the surrounding ...
Xin Niu, Lei Zhang, Yuchen Wu, Zhi Zong, Bin Wang, Jisheng Liu, Long Zhang, Fangfang Zhou   +7 more
doaj   +1 more source

Sequence variations of phase-separating proteins and resources for studying biomolecular condensates

Acta Biochimica et Biophysica Sinica, 2023
Phase separation (PS) is an important mechanism underlying the formation of biomolecular condensates. Physiological condensates are associated with numerous biological processes, such as transcription, immunity, signaling, and synaptic transmission ...
Guo Gaigai, Wang Xinxin, Zhang Yi, Li Tingting   +3 more
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BRD4-targeting PROTAC as a unique tool to study biomolecular condensates

Cell Discovery, 2023
Biomolecular condensates play key roles in various biological processes. However, specific condensation modulators are currently lacking. PROTAC is a new technology that can use small molecules to degrade target proteins specifically.
Yi Shi, Yuan Liao, Qianlong Liu, Zhihao Ni, Zhenzhen Zhang, Minglei Shi, Pilong Li, Haitao Li, Yu Rao   +8 more
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It’s Just a Phase: Exploring the Relationship Between mRNA, Biomolecular Condensates, and Translational Control

Frontiers in Genetics, 2022
Cells spatially organize their molecular components to carry out fundamental biological processes and guide proper development. The spatial organization of RNA within the cell can both promote and result from gene expression regulatory control.
Dylan M. Parker, Dylan M. Parker, Lindsay P. Winkenbach, Erin Osborne Nishimura   +3 more
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An evolutionarily nascent architecture underlying the formation and emergence of biomolecular condensates

Cell Reports, 2023
Summary: Biomolecular condensates are implicated in core cellular processes such as gene regulation and ribosome biogenesis. Although the architecture of biomolecular condensates is thought to rely on collective interactions between many components, it ...
Nima Jaberi-Lashkari, Byron Lee, Fardin Aryan, Eliezer Calo   +3 more
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Tuning the rheostat of immune gene translation

Stress Biology, 2023
Biomolecular condensates assembled through phase transitions regulate diverse aspects of plant growth, development, and stress responses. How biomolecular condensates control plant immunity is poorly understood. In Nature Plants, a new study (Zhou et al.,
Shuai Huang
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Surface tension and viscosity of protein condensates quantified by micropipette aspiration

Biophysical Reports, 2021
The material properties of biomolecular condensates have been suggested to play important biological and pathological roles. Despite the rapid increase in the number of biomolecules identified that undergo liquid-liquid phase separation, quantitative ...
Huan Wang, Fleurie M. Kelley, Dragomir Milovanovic, Benjamin S. Schuster, Zheng Shi   +4 more
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Coactivator condensation at super-enhancers links phase separation and gene control [PDF]

, 2019
Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity.
Abraham, Brian J., Boija, Ann, Chakraborty, Arup K, Cisse, Ibrahim I, Coffey, Eliot Leo, Dall’Agnese, Alessandra, Day, Daniel S., Guo, Yang E., Hannett, Nancy M., Hnisz, Denes, Klein, Isaac A., Lee, Tong Ihn, Li, Charles Han, Manteiga, John Colonnese, Sabari, Benjamin R., Schuijers, Jurian, Sharp, Phillip A., Shrinivas, Krishna, Vasile, Eliza, Young, Richard A., Zamudio Montes de Oca, Alicia   +20 more
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Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations

Nature Communications, 2022
Biomolecular condensates form via coupled associative and segregative phase transitions of multivalent associative macromolecules. Phase separation coupled to percolation is one example of such transitions.
Mina Farag, Samuel R. Cohen, Wade M. Borcherds, Anne Bremer, Tanja Mittag, Rohit V. Pappu   +5 more
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Multivalent interactions with RNA drive recruitment and dynamics in biomolecular condensates in Xenopus oocytes

iScience, 2022
Summary: RNA localization and biomolecular condensate formation are key biological strategies for organizing the cytoplasm and generating cellular polarity. In Xenopus oocytes, RNAs required for germ layer patterning localize in biomolecular condensates,
Sarah E. Cabral, Jessica P. Otis, Kimberly L. Mowry   +2 more
doaj   +1 more source