Results 11 to 20 of about 96,749 (190)
Crosstalk between Biomolecular Condensates and Proteostasis
Cells, 2022 Proper homeostasis of the proteome, referred to as proteostasis, is maintained by chaperone-dependent refolding of misfolded proteins and by protein degradation via the ubiquitin-proteasome system and the autophagic machinery.
Emmanuel Amzallag, Eran Hornstein
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Dynamical control enables the formation of demixed biomolecular condensates [PDF]
Nature Communications, 2023 Cellular matter can be organized into compositionally distinct biomolecular condensates. For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates with different RNA molecules.
Andrew Z. Lin +10 more
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Targeting biomolecular condensates: beyond dissolution. [PDF]
BMC BiolBiomolecular condensates control key cellular processes, from gene expression to signal transduction, by organizing molecules through selective compartmentalization.
Fleming C, Schuijers J.
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BMC BiologyIntrinsically disordered proteins (IDPs) and biomolecular condensates are critical for cellular processes and physiological functions. Abnormal biomolecular condensates can cause diseases such as cancer and neurodegenerative disorders.
Caolitao Qin +4 more
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Molecular BiomedicineCells constantly encounter environmental and physiological fluctuations that challenge homeostasis and threaten viability. In response to these cues, specific proteins and nucleic acids engage in multivalent interactions and undergo phase separation to ...
Sunkyung Choi, Jung-Min Lee, Kee K. Kim
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Focus on biomolecular condensates [PDF]
The Plant Cell, 2023 descripción no proporcionada por ...
Emilio Gutierrez-Beltran +2 more
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Allostery in Biomolecular Condensates. [PDF]
J Mol BiolAllosteric proteins and membrane-less biomolecular condensates are physics-governed pivotal functional components. Allosteric regulation is an inherent physical property of dynamic proteins, and dynamic proteins are allosteric. Thus, in biomolecular condensates (like everywhere else in the cell), allostery is at play, and often missing in condensate ...
Nussinov R, Regev C, Jang H.
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Biomolecular condensates in cancer biology [PDF]
Cancer Science, 2021 Abstract Understanding the characteristics of cancer cells is essential for the development of improved diagnosis and therapeutics. From a gene regulation perspective, the super‐enhancer concept has been introduced to systematically understand the molecular mechanisms underlying the identities of various cell types and has been ...
Hiroshi I. Suzuki, Koh Onimaru
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Biomolecular Condensates Formed by Designer Minimalistic Peptides [PDF]
, 2022 Inspired by the role of intracellular liquid-liquid phase separation (LLPS) in formation of membraneless organelles, there is great interest in developing dynamic compartments formed by LLPS of intrinsically disordered proteins (IDPs) or short peptides ...
Sian, Sloan-Dennison +17 more
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Macromolecular Regulation of the Material Properties of Biomolecular Condensates
, 2022 Biomolecular condensates inside cells contain dozens to hundreds of macromolecular components and are surrounded by many others. Our computational studies predicted that macromolecular regulators have matching effects on the phase equilibrium and ...
Divya Kota (9565851) +1 more
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