Results 21 to 30 of about 96,749 (190)
Regulation of biomolecular condensates by interfacial protein clusters [PDF]
, 2021 Pickering emulsions, droplet suspensions stabilized by solid particles, were discovered more than 100 years ago and are well studied in foods, oils, cosmetics, and pharmaceuticals.
Folkmann, Andrew +7 more
core +1 more source
Engineering synthetic biomolecular condensates
Nature Reviews Bioengineering, 2023 The concept of phase-separation-mediated formation of biomolecular condensates provides a new framework to understand cellular organization and cooperativity-dependent cellular functions. With growing understanding of how biological systems drive phase separation and how cellular functions are encoded by biomolecular condensates, opportunities have ...
Yifan Dai +2 more
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Nucleation landscape of biomolecular condensates
Nature, 2021 All structures within living cells must form at the right time and place. This includes condensates such as the nucleolus, Cajal bodies and stress granules, which form via liquid-liquid phase separation of biomolecules, particularly proteins enriched in intrinsically disordered regions (IDRs)1,2.
Shimobayashi, Shunsuke +4 more
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Biomolecular condensation involving the cytoskeleton
Brain Research Bulletin, 2023 Biomolecular condensation of proteins contributes to the organization of the cytoplasm and nucleoplasm. A number of condensation processes appear to be directly involved in regulating the structure, function and dynamics of the cytoskeleton. Liquid-liquid phase separation of cytoskeleton proteins, together with polymerization modulators, promotes ...
Satabdee Mohapatra, Susanne Wegmann
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Molecular structure in biomolecular condensates [PDF]
Current Opinion in Structural Biology, 2020 Evidence accumulated over the past decade provides support for liquid-liquid phase separation as the mechanism underlying the formation of biomolecular condensates, which include not only membraneless organelles such as nucleoli and RNA granules, but additional assemblies involved in transcription, translation and signaling. Understanding the molecular
Ivan Peran, Tanja Mittag
openaire +3 more sources
Frontiers in Genetics, 2022 Cells spatially organize their molecular components to carry out fundamental biological processes and guide proper development. The spatial organization of RNA within the cell can both promote and result from gene expression regulatory control.
Dylan M. Parker +3 more
doaj +1 more source
Microfluidics for multiscale studies of biomolecular condensates. [PDF]
, 2022 Membraneless organelles formed through condensation of biomolecules in living cells have become the focus of sustained efforts to elucidate their mechanisms of formation and function.
core +4 more sources
Tuning the rheostat of immune gene translation
Stress Biology, 2023 Biomolecular condensates assembled through phase transitions regulate diverse aspects of plant growth, development, and stress responses. How biomolecular condensates control plant immunity is poorly understood. In Nature Plants, a new study (Zhou et al.,
Shuai Huang
doaj +1 more source
Cell Reports, 2023 Summary: Biomolecular condensates are implicated in core cellular processes such as gene regulation and ribosome biogenesis. Although the architecture of biomolecular condensates is thought to rely on collective interactions between many components, it ...
Nima Jaberi-Lashkari +3 more
doaj +1 more source
Cell Communication and Signaling, 2021 Background Biomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization.
Ryan J. Emenecker +2 more
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