Results 41 to 50 of about 96,749 (190)
, 2021 Correction to “Phosphorylation of a Human Microprotein Promotes Dissociation of Biomolecular ...
Alexandra Khitun (4445257) +13 more
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Biomolecular condensates in autophagy regulation
Current Opinion in Cell Biology, 2021 Autophagy is an intracellular degradation system that contributes to cellular homeostasis. Autophagosome formation is a landmark event in autophagy, which sequesters and delivers cytoplasmic components to the lysosome for degradation. Based on selectivity, autophagy can be classified into bulk and selective autophagy, which are mechanistically distinct
Yuko, Fujioka, Nobuo N, Noda
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Fundamental Aspects of Phase-Separated Biomolecular Condensates [PDF]
Biomolecular condensates, formed through phase separation, are upending our understanding in much of molecular, cell, and developmental biology. There is an urgent need to elucidate the physicochemical foundations of the behaviors and properties of ...
Huan-Xiang, Zhou +3 more
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, 2019 We highlight previous incompletely understood cell biology data in the STAT3 signaling field with respect to interleukin-6 (IL-6)-induced activation of this transcription factor in hepatoma cells to generate cytoplasmic and nuclear STAT3 bodies.
Pravin B. Sehgal
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Biomolecular condensates-Prerequisites for anhydrobiosis? [PDF]
Protein SciAbstract It is often underappreciated that despite water being a requirement for life on Earth, organisms belonging to all taxonomic kingdoms have developed mechanisms to survive desiccation. These organisms, referred to as anhydrobiotes, accumulate specific biomolecules during or before drying that facilitate the survival of ...
Elder CA +9 more
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The mechanobiology of biomolecular condensates
Biophysics ReviewsThe central goal of mechanobiology is to understand how the mechanical forces and material properties of organelles, cells, and tissues influence biological processes and functions. Since the first description of biomolecular condensates, it was hypothesized that they obtain material properties that are tuned to their functions inside cells. Thus, they
Neus Sanfeliu-Cerdán, Michael Krieg
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Emergent microenvironments of nucleoli
NucleusIn higher eukaryotes, the nucleolus harbors at least three sub-phases that facilitate multiple functionalities including ribosome biogenesis. The three prominent coexisting sub-phases are the fibrillar center (FC), the dense fibrillar component (DFC ...
Matthew R. King +2 more
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Surface tension measurement and calculation of model biomolecular condensates [PDF]
, 2023 The surface tension of liquid-like protein-rich biomolecular condensates is an emerging physical principle governing the mesoscopic interior organisation of biological cells.
Alfonso A. Castrejón-Pita +12 more
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Frontiers in Environmental Chemistry, 2022 The existence of membrane-less organelles in the cells has been known for a relatively long time. Of the membrane-less organelles, stress granules, processing bodies, and PML-NBs have been intensively investigated in relation to arsenic.
Osamu Udagawa, Seishiro Hirano
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Mechanisms of active regulation of biomolecular condensates [PDF]
Trends in Cell Biology, 2019 Abstract Liquid-liquid phase separation is a key organizational principle in eukaryotic cells, on par with intracellular membranes. It allows cells to concentrate specific proteins into condensates, increasing reaction rates and achieving switch-like regulation.
Söding, Johannes +4 more
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