Results 61 to 70 of about 96,749 (190)
Susceptibility and Regulation of Biomolecular Condensates by Solutes
Proceedings of the National Academy of SciencesMetabolites are abundant in cells, where condensation of proteins and nucleic acids can organize cellular contents without membranes. Condensates form and dissolve dynamically in response to diverse cellular processes. Understanding condensate phase behavior using full phase diagrams is hampered by the sheer number of distinct molecular species ...
Matsuzawa T +10 more
europepmc +5 more sources
Designing Synthetic Biomolecular Condensates in Bacteria
, 2021 Despite lacking many of the organelles possessed by eukaryotes, bacteria are able to localize important enzymes and signaling proteins to specific subcellular locations. One way that bacteria accomplish this localization is through the formation of phase
Whitlock, Sara
core
G-Quadruplexes in Nuclear Biomolecular Condensates
, 2023 G-quadruplexes (G4s) have long been implicated in the regulation of chromatin packaging and gene expression. These processes require or are accelerated by the separation of related proteins into liquid condensates on DNA/RNA matrices.
Vjacheslav Severov +4 more
core +1 more source
Nature Communications, 2023 Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of distinct biomolecular condensates that form via phase separation coupled to percolation.
Mina Farag +4 more
doaj +1 more source
Chaperones Remodel Stress-Induced Biomolecular Condensates [PDF]
, 2021 Stresses such as heat shock trigger formation of protein aggregates and induction of a disaggregation system composed of molecular chaperones. Recent work reveals that several cases of apparent heat-induced aggregation, long thought to be the result of ...
Yoo, Haneul
core +1 more source
Diffusiophoresis promotes phase separation and transport of biomolecular condensates
Nature CommunicationsThe internal microenvironment of a living cell is heterogeneous and comprises a multitude of organelles with distinct biochemistry. Amongst them are biomolecular condensates, which are membrane-less, phase-separated compartments enriched in system ...
Viet Sang Doan +4 more
doaj +1 more source
Nature Communications, 2023 Neuronal communication relies on the release of neurotransmitters from various populations of synaptic vesicles. Despite displaying vastly different release probabilities and mobilities, the reserve and recycling pool of vesicles co-exist within a single
Shanley F. Longfield +10 more
doaj +1 more source
Linking Biomolecular Condensates to Disease and Therapeutic Development
, 2023 The cell is compartmentalized into membrane-bound and membraneless organelles that organize and regulate key cellular functions. Over the past decade, growing evidence supports the notion that membraneless organelles, called biomolecular condensates ...
Hawken, Susana W.
core
ATP-induced crosslinking of a biomolecular condensate
, 2023 Abstract DEAD-box helicases are important regulators of biomolecular condensates. However, the mechanisms through which these enzymes affect the dynamics of biomolecular condensates have not been systematically explored. Here, we demonstrate the mechanism by which mutation of a DEAD-box helicase’s catalytic core alters ribonucleoprotein
Sebastian Coupe, Nikta Fakhri
openaire +2 more sources
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates [PDF]
Integrating in vitro and in silico experiments allows CTPR biomolecular condensates to be rationally designed in a facile and versatile way, modulating protein–protein interactions in the dense phase through specific recruitment of target proteins.
core +8 more sources