Results 51 to 60 of about 96,749 (190)

Liquid–liquid phase separation within fibrillar networks

Nature Communications, 2023
Complex fibrillar networks mediate liquid–liquid phase separation of biomolecular condensates within the cell. Mechanical interactions between these condensates and the surrounding networks are increasingly implicated in the physiology of the condensates
Jason X. Liu, Mikko P. Haataja, Andrej Košmrlj, Sujit S. Datta, Craig B. Arnold, Rodney D. Priestley   +5 more
doaj   +1 more source

RNA-mediated demixing transition of low-density condensates

Nature Communications, 2023
Biomolecular condensates play a key role in organizing cellular reactions by concentrating a specific set of biomolecules. However, whether condensate formation is accompanied by an increase in the total mass concentration within condensates or by the ...
Taehyun Kim, Jaeyoon Yoo, Sungho Do, Dong Soo Hwang, YongKeun Park, Yongdae Shin   +5 more
doaj   +1 more source

Organization and Function of Non-dynamic Biomolecular Condensates

, 2017
Cells compartmentalize biochemical reactions using organelles. Organelles can be either membrane-bound compartments or supramolecular assemblies of protein and ribonucleic acid known as 'biomolecular condensates'.
Elvan Boke, Woodruff, J., Hyman, A., Jeffrey B. Woodruff, Anthony A. Hyman, Boke, E.   +5 more
core   +1 more source

Biomolecular Condensates in Contact with Membranes

Annual Review of Biophysics
Biomolecular condensates are highly versatile membraneless organelles involved in a plethora of cellular processes. Recent years have witnessed growing evidence of the interaction of these droplets with membrane-bound cellular structures. Condensates’ adhesion to membranes can cause their mutual molding and regulation, and their interaction is of ...
Mangiarotti, A. ; https://orcid.org/0000-0003-2694-6200, Dimova, R. ; https://orcid.org/0000-0002-3872-8502   +1 more
openaire   +3 more sources

Biomolecular Condensates in Myeloid Leukemia: What Do They Tell Us?

, 2023
Recent studies have suggested that several oncogenic and tumor-suppressive proteins carry out their functions in the context of specific membrane-less cellular compartments.
Jevtic, Zivojin (University of Basel), Schwaller, Juerg (University of Basel), Allram, Melanie (University of Veterinary Medicine Vienna), Grebien, Florian (University of Veterinary Medicine Vienna)   +3 more
core   +2 more sources

Chaperone regulation of biomolecular condensates

Frontiers in Biophysics
Biomolecular condensation allows for the dynamic organization of molecules in time and space. Condensate formation is regulated through many mechanisms including the action of molecular chaperones. While molecular chaperones have long been viewed through the lens of their roles in protein folding, misfolding, and quality control, their ability to ...
Bard, Jared A. M., Drummond, D. Allan
openaire   +3 more sources

Decoding the genomic landscape of chromatin-associated biomolecular condensates

Nature Communications
Biomolecular condensates play a significant role in chromatin activities, primarily by concentrating and compartmentalizing proteins and/or nucleic acids.
Zhaowei Yu, Qi Wang, Qichen Zhang, Yawen Tian, Guo Yan, Jidong Zhu, Guangya Zhu, Yong Zhang   +7 more
doaj   +1 more source

Model biomolecular condensates have heterogeneous structure quantitatively dependent on the interaction profile of their constituent macromolecules [PDF]

, 2022
International audienceModel biomolecular condensates have heterogeneous material properties that are tuned by the number and distribution of their constituent proteins’ sticky binding ...
Shillcock, Julian C, Alexandre, Jérémy, Ipsen, John, Vuillon, Laurent, Lagisquet, Clément, Ipsen, John H, Shillcock, Julian   +6 more
core   +1 more source

Methyladenine as a regulator of biomolecular condensation

Frontiers in Molecular Biosciences
Ribonucleotide modifications modulate RNA structure and stability, thereby influencing RNA turnover and a wide range of cellular functions. Recent studies have revealed that specific RNA modifications can also affect the formation, composition, and material properties of biomolecular condensates.
Arsiè, Roberto, Tartaglia, Gian G., Vabulas, R. Martin   +2 more
openaire   +2 more sources

Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization

Genome Biology, 2021
Background Biomolecular condensates have been implicated in multiple cellular processes. However, the global role played by condensates in 3D chromatin organization remains unclear.
Xinyi Liu, Shaoshuai Jiang, Lin Ma, Jiale Qu, Longying Zhao, Xing Zhu, Junjun Ding   +6 more
doaj   +1 more source