Results 31 to 40 of about 96,749 (190)

The exchange dynamics of biomolecular condensates

eLife, 2022
Abstract A hallmark of biomolecular condensates formed via liquid-liquid phase separation is that they dynamically exchange material with their surroundings, and this process can be crucial to condensate function. Intuitively, the rate of exchange can be limited by the flux from the dilute phase or by the mixing speed in the dense phase.
Yaojun Zhang, Andrew GT Pyo, Ross Kliegman, Yoyo Jiang, Clifford P Brangwynne, Howard A Stone, Ned S Wingreen   +6 more
openaire   +3 more sources

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations

Nature Communications, 2022
Biomolecular condensates form via coupled associative and segregative phase transitions of multivalent associative macromolecules. Phase separation coupled to percolation is one example of such transitions.
Mina Farag, Samuel R. Cohen, Wade M. Borcherds, Anne Bremer, Tanja Mittag, Rohit V. Pappu   +5 more
doaj   +1 more source

Surface tension and viscosity of protein condensates quantified by micropipette aspiration

Biophysical Reports, 2021
The material properties of biomolecular condensates have been suggested to play important biological and pathological roles. Despite the rapid increase in the number of biomolecules identified that undergo liquid-liquid phase separation, quantitative ...
Huan Wang, Fleurie M. Kelley, Dragomir Milovanovic, Benjamin S. Schuster, Zheng Shi   +4 more
doaj   +1 more source

Multivalent interactions with RNA drive recruitment and dynamics in biomolecular condensates in Xenopus oocytes

iScience, 2022
Summary: RNA localization and biomolecular condensate formation are key biological strategies for organizing the cytoplasm and generating cellular polarity. In Xenopus oocytes, RNAs required for germ layer patterning localize in biomolecular condensates,
Sarah E. Cabral, Jessica P. Otis, Kimberly L. Mowry   +2 more
doaj   +1 more source

Stress-related biomolecular condensates in plants [PDF]

, 2023
This review describes the mechanism, regulation, composition, and properties of stress-related biomolecular condensates in plants.Biomolecular condensates are membraneless organelle-like structures that can concentrate molecules and often form through ...
Moschou, Fernie, Alisdair R., Solis-Miranda, Jorge, Gutierrez-Beltran, Emilio, Skirycz, Aleksandra, Chodasiewicz, Monika, Moschou, Panagiotis Nikolaou, Bozhkov, Peter   +7 more
core  

Artificial biomolecular condensates [PDF]

Nature Methods, 2018
Synthetic small molecules can form liquid-phase condensates and simultaneously sequester intracellular enzymes.
openaire   +2 more sources

Protein conformation and biomolecular condensates

Current Research in Structural Biology, 2022
Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts. An avalanche of studies highlighted the central role of biomolecular condensates in membraneless subcellular ...
Diego S. Vazquez, Pamela L. Toledo, Alejo R. Gianotti, Mario R. Ermácora   +3 more
openaire   +3 more sources

Biomolecular condensates in neurodegeneration and cancer [PDF]

Traffic, 2019
Abstract The intracellular environment is partitioned into functionally distinct compartments containing specific sets of molecules and reactions. Biomolecular condensates, also referred to as membrane‐less organelles, are diverse and abundant cellular compartments that lack membranous enclosures.
Stephanie Spannl, Maria Tereshchenko, Giovanni J. Mastromarco, Sean J. Ihn, Hyun O. Lee   +4 more
openaire   +2 more sources

Topological Considerations in Biomolecular Condensation

Biomolecules, 2023
Biomolecular condensation and phase separation are increasingly understood to play crucial roles in cellular compartmentalization and spatiotemporal regulation of cell machinery implicated in function and pathology. A key aspect of current research is to gain insight into the underlying physical mechanisms of these processes.
Debapriya Das, Ashok A. Deniz
openaire   +3 more sources

Micellization: A new principle in the formation of biomolecular condensates

Frontiers in Molecular Biosciences, 2022
Phase separation is a fundamental mechanism for compartmentalization in cells and leads to the formation of biomolecular condensates, generally containing various RNA molecules.
Tomohiro Yamazaki, Tetsuya Yamamoto, Tetsuro Hirose, Tetsuro Hirose   +3 more
doaj   +1 more source