Results 71 to 80 of about 96,749 (190)
Modern optical microscopy methods to study biomolecular condensates
, 2021 © 2021 Elsevier Ltd. Cells achieve highly intricate internal organization via membrane-bound and membraneless organelles. Research over the past decade has implicated liquid–liquid phase separation, a phenomenon by which charged and often disordered ...
Anisha Shakya, John T. King
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To condense or not to condense: Wnt regulation by centrosome-nucleated biomolecular condensates
Proceedings of the National Academy of Sciences, 2022 Colorectal cancer is the third leading cause of cancer deaths worldwide, and, thus, understanding genetic changes driving cancer development and progression is critical. A key breakthrough occurred 31 y ago when scientists cloned the tumor suppressor gene adenomatous polyposis coli (APC), mutated in families with a predisposition to colon cancer ...
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Communications ChemistryBiomolecular condensates formed by intrinsically disordered proteins (IDPs) are semidilute solutions. These can be approximated as solutions of blob-sized segments, which are peptide-sized motifs.
Xiangze Zeng, Rohit V. Pappu
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Signal Transduction and Targeted TherapyCells orchestrate their processes through complex interactions, precisely organizing biomolecules in space and time. Recent discoveries have highlighted the crucial role of biomolecular condensates—membrane-less assemblies formed through the condensation
Soyoung Jeon +5 more
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An experimental framework to assess biomolecular condensates in bacteria
Nature CommunicationsHigh-resolution imaging of biomolecular condensates in living cells is essential for correlating their properties to those observed through in vitro assays. However, such experiments are limited in bacteria due to resolution limitations.
Y Hoang +5 more
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Functional specificity in biomolecular condensates revealed by genetic complementation [PDF]
Biomolecular condensates are thought to create subcellular microenvironments that regulate specific biochemical activities. Extensive in vitro work has helped link condensate formation to a wide range of cellular processes, including gene expression ...
Hnisz, D. ; https://orcid.org/ +3 more
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Decoding intrinsically disordered regions in biomolecular condensates
Biomolecular condensates comprise a diverse array of molecular entities, with intrinsically disordered regions (IDRs) receiving mounting attention due to their pivotal roles. In recent years, significant progress has been made in understanding the linear
Minglei Shi +3 more
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Modulation of B cell receptor activation by antibody competition
Cell ReportsSummary: During repeated virus exposure, pre-existing antibodies can mask viral epitopes by competing with B cell receptors for antigen. Although epitope masking has the potential to steer B cell responses away from conserved epitopes and toward those ...
Yuanyuan He +2 more
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Grand challenges in biomolecular condensates: structure, function, and formation
Biomolecular condensates describe concentrated nonstoichiometric assemblies of biomolecules that can form by a range of different mechanisms 1). Biomolecular condensates can arise by phase separation, which in biology involves the demixing of a water ...
Hatters, DM
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Biomolecular condensates in plant immunity
Cell Host & MicrobePlant defense against microbial pathogens relies on coordinated regulation of diverse molecular processes. Although much has been learned about these processes through traditional and modern approaches, recent findings indicate that they are orchestrated through membraneless biomolecular condensates formed via liquid-liquid phase separation and related
Shuai Huang, Xinnian Dong
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