Results 71 to 80 of about 10,366 (238)

Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates

BMC Biology
Intrinsically disordered proteins (IDPs) and biomolecular condensates are critical for cellular processes and physiological functions. Abnormal biomolecular condensates can cause diseases such as cancer and neurodegenerative disorders.
Caolitao Qin, Yun-Long Wang, Jian Zheng, Xiang-Bo Wan, Xin-Juan Fan   +4 more
doaj   +1 more source

Probabilistic state preparation of a single molecular ion by projection measurement

, 2005
We show how to prepare a single molecular ion in a specific internal quantum state in a situation where the molecule is trapped and sympathetically cooled by an atomic ion and where its internal degrees of freedom are initially in thermal equilibrium ...
Bertelsen A, I S Vogelius, L B Madsen, M Drewsen, Rice S, Rohde H, Smith M, Wineland D J   +7 more
core   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

The ERC1 scaffold protein implicated in cell motility drives the assembly of a liquid phase [PDF]

, 2019
Several cellular processes depend on networks of proteins assembled at specific sites near the plasma membrane. Scaffold proteins assemble these networks by recruiting relevant molecules.
Cammarota, Eugenia, Corbetta, Agnese, de Curtis, Ivan, Degano, Massimo, Fesce, Riccardo, Mazza, Davide, Minici, Claudia, Murray, David H., Ramella, Martina, Ribolla, Lucrezia, Sala, Kristyna, Tonoli, Diletta   +11 more
core   +2 more sources

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

Effect of reaction time on structural properties of ZnO:Al films [PDF]

, 2015
Undoped and Al doped ZnO films are obtained by chemical bath deposition onto glass substrates. Investigations of the effect of reaction time on structural and sub-structural features were carried out using high resolution scanning electron microscopy ...
Berestok, Taisiia Oleksandrivna, Cheong, H., Kurbatov, Denys Ihorovych, Lakshminarayana, D., Opanasiuk, Anatolii Serhiiovych, Panchal, C.J., Suryavanshi, Priya, Trivedi, U.B., Бересток, Таисия Александровна, Бересток, Таїсія Олександрівна, Курбатов, Денис Игоревич, Курбатов, Денис Ігорович, Опанасюк, Анатолий Сергеевич, Опанасюк, Анатолій Сергійович   +13 more
core   +1 more source

Electronic structure and rovibrational predissociation of the 2sPi state in KLi

, 2018
Adiabatic potential energy curves of the 3sSigma+, 3tSigma+, 2sPi and 2tPi states correlating for large internuclear distance with the K(4s) + Li(2p) atomic asymptote were calculated.
Henriksen, N. E., Jasik, P., Kilich, T., Kozicki, J., Sienkiewicz, J. E.   +4 more
core   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Concentrating and sequestering biomolecules in condensates: impact on plant biology [PDF]

, 2023
Biomolecules can exist in a variety of forms, ranging from single entities to mesoscale assemblies akin to small organelles, also known as ‘biomolecular condensates’.
Bozhkov, Peter, Hatzianestis, Ioannis H., Moschou, Panagiotis N., Moschou, Panagiotis Nikolaou, Moschou, Panagiotis Nikolaou, Mountourakis, Fanourios, Stavridou, Stella   +6 more
core  

BLADE‐ON‐PETIOLE Genes Enable Genetic Bottleneck Mitigation Through Cross‐Species Repurposing of Floral Persistence Traits

Advanced Science, EarlyView.
This study shows that BLADE‐ON‐PETIOLE (BOP) proteins regulate floral abscission and senescence in tomato by interacting with TFAM1 to form transcriptional condensates controlling the ARABIDOPSIS THALIANA HOMEOBOX GENE 1 (ATH1)‐mediated abscission pathway.
Nan Xiao, Qianwen Lyu, Tinghao Zhang, Yupan Zou, Yue Xie, Dandan Yang, Cao Xu, Xiaozhen Huang   +7 more
wiley   +1 more source