Results 91 to 100 of about 96,749 (190)

Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer

Biomolecular condensates, the membraneless cellular compartments formed by liquid–liquid phase separation (LLPS), represent an important mechanism for physiological and tumorigenic processes.
Zhong, Xiaowen, Lu, Q Richard, Ahad, Leena, Kiang, Karrie M   +3 more
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Biomolecular condensates form spatially inhomogeneous network fluids [PDF]

The functions of biomolecular condensates are thought to be influenced by their material properties, and these will be determined by the internal organization of molecules within condensates.
Cohen, Samuel R, Kriwacki, Richard W, Stanley, Christopher B, Dar, Furqan, Mitrea, Diana M, Leite, Wellington C, Pappu, Rohit V, Choi, Jeong-Mo, Phillips, Aaron H, Nagy, Gergely   +9 more
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From the classical colloidal theory to biomolecular condensation: implications in health and disease

Frontiers in Biophysics
Biomolecular phase separation and condensation are fundamental mechanisms of cellular compartmentalization that regulate biochemical processes in space and time.
Noelia A. Melian, Noelia A. Melian, Aldana Gomez, Milagros B. Abate, Milagros B. Abate, Pamela L. Toledo, Pamela L. Toledo, Mario R. Ermácora, Mario R. Ermácora, Mario R. Ermácora, Diego S. Vazquez, Diego S. Vazquez, Diego S. Vazquez   +12 more
doaj   +1 more source

Phase-separated biomolecular condensates for biocatalysis

Trends in Biotechnology
Nature often uses dynamically assembling multienzymatic complexes called metabolons to achieve spatiotemporal control of complex metabolic reactions. Researchers are aiming to mimic this strategy of organizing enzymes to enhance the performance of artificial biocatalytic systems.
Samuel Lim, Douglas S. Clark
openaire   +2 more sources

Intrinsically disordered regions and RNA binding domains contribute to protein enrichment in biomolecular condensates in Xenopus oocytes

Scientific Reports
Proteins containing both intrinsically disordered regions (IDRs) and RNA binding domains (RBDs) can phase separate in vitro, forming bodies similar to cellular biomolecular condensates.
Liam C. O’Connell, Victoria Johnson, Jessica P. Otis, Anika K. Hutton, Anastasia C. Murthy, Mark C. Liang, Szu-Huan Wang, Nicolas L. Fawzi, Kimberly L. Mowry   +8 more
doaj   +1 more source

Biomolecular Condensates as Emerging Biomaterials: Functional Mechanisms and Advances in Computational and Experimental Approaches

Biomolecular condensates, a ubiquitous class of biomaterials found in living cells, have been shown to be responsible for key physiological processes, such as gene regulation, signal transduction, and stress response.
Haibo Yu (19586578), Phuong Dzung Do-Ha (19583038), I Kabakova (14413791), WP Bowen (19153168), P Sasheva (22594256), Luke McAlary (19586302), H Mahmodi (14413788), Q Zhu (4701358), Lezanne Ooi (19588228), Z Raza (16184174), E De Costa (22594253)   +10 more
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Probing the surface charge of condensates using microelectrophoresis

Nature Communications
Biomolecular condensates play an important role in cellular organization. Coacervates are commonly used models that mimic the physicochemical properties of biomolecular condensates.
Merlijn H. I. van Haren, Brent S. Visser, Evan Spruijt   +2 more
doaj   +1 more source

Label-Free Techniques for Probing Biomolecular Condensates

Biomolecular condensates play important roles in a wide array of fundamental biological processes, such as cellular compartmentalization, cellular regulation, and other biochemical reactions. Since their discovery and first observations, an extensive and
Ibrahim, Khalid A., Miljkovic, Helena, Yang, Wayne, Radenovic, Aleksandra, Naidu, Akhil Sai   +4 more
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All-atom simulations of biomolecular condensates

Current Opinion in Structural Biology
Biomolecular condensates shape a wide spectrum of physiological and pathological processes, yet the molecular mechanisms underlying their formation and activity are still to be fully understood. Molecular simulations can provide valuable insights into the structure and dynamics of such condensates, and coarse-grained simulations have been widely used ...
Miloš T. Ivanović, Robert B. Best
openaire   +2 more sources

Chemically Informed Coarse-Graining of Electrostatic Forces in Charge-Rich Biomolecular Condensates. [PDF]

Biomolecular condensates composed of highly charged biomolecules, such as DNA, RNA, chromatin, and nucleic-acid binding proteins, are ubiquitous in the cell nucleus.
Jorge Ramirez, Maristany, M. Julia, Ramirez, Jorge, Espinosa, Jorge R., Pin Yu Chew, Aguirre Gonzalez, Anne, Anne Aguirre Gonzalez, Kieran Russell, Rosana Collepardo-Guevara, R. Tejedor, Andrés, Andrés R. Tejedor, Jorge R. Espinosa, M. Julia Maristany, Collepardo-Guevara, Rosana, Chew, Pin Yu, Russell, Kieran   +15 more
core   +2 more sources