Results 101 to 110 of about 10,366 (238)

Protein Condensate Atlas from predictive models of heteromolecular condensate composition

Nature Communications
Biomolecular condensates help cells organise their content in space and time. Cells harbour a variety of condensate types with diverse composition and many are likely yet to be discovered.
Kadi L. Saar, Rob M. Scrutton, Kotryna Bloznelyte, Alexey S. Morgunov, Lydia L. Good, Alpha A. Lee, Sarah A. Teichmann, Tuomas P. J. Knowles   +7 more
doaj   +1 more source

Searching for quantum optimal controls under severe constraints

, 2015
The success of quantum optimal control for both experimental and theoretical objectives is connected to the topology of the corresponding control landscapes, which are free from local traps if three conditions are met: (1) the quantum system is ...
Brif, Constantin, Ho, Tak-San, Long, Ruixing, Rabitz, Herschel, Riviello, Gregory, Tibbetts, Katharine Moore, Wu, Re-Bing   +6 more
core   +1 more source

Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation. [PDF]

, 2019
RNA Polymerase II (Pol II) and transcription factors form concentrated hubs in cells via multivalent protein-protein interactions, often mediated by proteins with intrinsically disordered regions.
Darzacq, Xavier, Dugast-Darzacq, Claire, Hansen, Anders S, Hao, Yvonne, Heckert, Alec Basil, Marie-Nelly, Hervé, McSwiggen, David Trombley, Teves, Sheila S, Tjian, Robert, Umemoto, Kayla K   +9 more
core  

Intrinsic hydrophobicity of IDP-based biomolecular condensates drives their partial drying on membrane surfaces [PDF]

The localization of biomolecular condensates to intracellular membrane surfaces has emerged as an important feature of sub-cellular organization. In this work, we study the wetting behavior of biomolecular condensates on various substrates.
Aarts, D. G. A. L., Holland, J., Nott, T. J.   +2 more
core   +2 more sources

A computational pipeline for image-based statistical analysis of biomolecular condensates dynamics using morphological descriptors

Scientific Reports
Biomolecular condensation has been extensively studied recently, yet advanced analytical methods for characterizing phase-separated systems remain limited.
Ivan Rosa e Silva, Guilherme Gurian Dariani, Felipe Zanghelini Benevenutti, Renata Rocha de Oliveira, Vitória Yumi Uetuki Nicoleti, Murilo de Carvalho   +5 more
doaj   +1 more source

In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation

Angewandte Chemie International Edition, EarlyView.
Chromophore engineering of isoquinoline aldehydes generates TICT‐based fluorogenic dyes for in situ labeling of diverse (bio)molecules with large Stokes shifts compatible with cell imaging. ABSTRACT Simple, efficient transformations of fluorogenic nature that proceed under biocompatible conditions without the formation of byproducts are of high ...
Dongchen Du, László Albert, Milan Weitzel, Linda E. Eijsink, Elena R. Cotroneo, Dennis Marzin, Felipe Opazo, Nadja A. Simeth   +7 more
wiley   +1 more source

Controlled and orthogonal partitioning of large particles into biomolecular condensates

Nature Communications
Partitioning of client molecules into biomolecular condensates is critical for regulating the composition and function of condensates. Previous studies suggest that client size limits partitioning.
Fleurie M. Kelley, Anas Ani, Emily G. Pinlac, Bridget Linders, Bruna Favetta, Mayur Barai, Yuchen Ma, Arjun Singh, Gregory L. Dignon, Yuwei Gu, Benjamin S. Schuster   +10 more
doaj   +1 more source

Full‐Length FUS Protein Condensates Adopt a Domain‐Preferential Spatial Architecture

Aggregate
Biomolecular condensates play crucial roles in cellular physiology and are implicated in neurodegenerative diseases and cancer. However, the mechanisms governing their formation and spatial organization remain poorly understood, largely due to technical ...
Si‐Cheng Tong, Yang Jiang, Yi‐Nan Guo, Yong Wang, Li Zhao, Zhong‐Yuan Lu   +5 more
doaj   +1 more source

Methane Pyrolysis Performance in Catalytic Molten Media for Hydrogen Production From the Perspective of Bubble Column Reactor Design and Configuration

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT In the hydrogen production routes from natural gas (methane), methane pyrolysis offers a cleaner option than the established steam methane reforming by producing CO2‐free hydrogen. However, in fixed bed reactors over solid catalysts, this technology experiences rapid catalyst deactivation due to carbon (coke) deposition encapsulating its ...
Muhammad Irfan Fakarudin, Luqmanulhakim Baharudin, Matthew J. Watson, Wan Nor Roslam Wan Isahak   +3 more
wiley   +1 more source

Modulation of B cell receptor activation by antibody competition

Cell Reports
Summary: During repeated virus exposure, pre-existing antibodies can mask viral epitopes by competing with B cell receptors for antigen. Although epitope masking has the potential to steer B cell responses away from conserved epitopes and toward those ...
Yuanyuan He, Zijian Guo, Michael D. Vahey   +2 more
doaj   +1 more source