Results 81 to 90 of about 96,749 (190)

A Molecular Recruitment Colocalization Platform for Visualizing Multi‐Protein Interactions and Engineering Biomolecular Condensates in Living Cells

Advanced Science
Visualizing dynamic protein–protein interactions (PPIs) and phase‐separated biomolecular condensates in live cells is crucial for understanding cellular processes.
Lei Peng, Yu Hou, Yan Zhao, Jing‐Ya Tang, Liu Song, Bo Peng, Min Li, Dian‐Bing Wang, Xian‐En Zhang   +8 more
doaj   +1 more source

Protein Condensate Atlas from predictive models of heteromolecular condensate composition

Nature Communications
Biomolecular condensates help cells organise their content in space and time. Cells harbour a variety of condensate types with diverse composition and many are likely yet to be discovered.
Kadi L. Saar, Rob M. Scrutton, Kotryna Bloznelyte, Alexey S. Morgunov, Lydia L. Good, Alpha A. Lee, Sarah A. Teichmann, Tuomas P. J. Knowles   +7 more
doaj   +1 more source

A computational pipeline for image-based statistical analysis of biomolecular condensates dynamics using morphological descriptors

Scientific Reports
Biomolecular condensation has been extensively studied recently, yet advanced analytical methods for characterizing phase-separated systems remain limited.
Ivan Rosa e Silva, Guilherme Gurian Dariani, Felipe Zanghelini Benevenutti, Renata Rocha de Oliveira, Vitória Yumi Uetuki Nicoleti, Murilo de Carvalho   +5 more
doaj   +1 more source

Controlled and orthogonal partitioning of large particles into biomolecular condensates

Nature Communications
Partitioning of client molecules into biomolecular condensates is critical for regulating the composition and function of condensates. Previous studies suggest that client size limits partitioning.
Fleurie M. Kelley, Anas Ani, Emily G. Pinlac, Bridget Linders, Bruna Favetta, Mayur Barai, Yuchen Ma, Arjun Singh, Gregory L. Dignon, Yuwei Gu, Benjamin S. Schuster   +10 more
doaj   +1 more source

Do biomolecular condensates regulate the transcriptional and post-transcriptional responses of plant roots to water deficit?

Quantitative Plant Biology
Water deficit at the plant cell level can be assimilated to a reduction in turgor pressure and an increase in osmotic pressure. In a previous work, we showed that the mRNA abundance of some genes displays a quantitative relationship to these ...
Coralie Masson, Hanzhang Yu, Fabrice Bauget, Dominique Gagliardi, Yann Boursiac   +4 more
doaj   +1 more source

A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells

Nature Communications
Proteins with chemically regulatable phase separation are of great interest in the fields of biomolecular condensates and synthetic biology. Intrinsically disordered proteins (IDPs) are the dominating building blocks of biomolecular condensates which ...
Jinglei Nie, Xinyi Zhang, Zhijuan Hu, Wei Wang, Martin A. Schroer, Jie Ren, Dmitri Svergun, Anyang Chen, Peiguo Yang, An-Ping Zeng   +9 more
doaj   +1 more source

Terms Related to The Study of Biomacromolecular Condensates

Shengwu huaxue yu shengwu wuli jinzhan
Biomolecular condensates are formed through phase separation of biomacromolecules such as proteins and RNAs. These condensates exhibit liquid-like properties that can futher transition into more stable material states.
RUAN Ke, FANG Xiao-Feng, LI Dan, LI Pi-Long, LIN Yi, WANG Zheng, SHI Yun-Yu, ZHANG Ming-Jie, ZHANG Hong, LIU Cong   +9 more
doaj   +1 more source

Full‐Length FUS Protein Condensates Adopt a Domain‐Preferential Spatial Architecture

Aggregate
Biomolecular condensates play crucial roles in cellular physiology and are implicated in neurodegenerative diseases and cancer. However, the mechanisms governing their formation and spatial organization remain poorly understood, largely due to technical ...
Si‐Cheng Tong, Yang Jiang, Yi‐Nan Guo, Yong Wang, Li Zhao, Zhong‐Yuan Lu   +5 more
doaj   +1 more source

Biomolecular Condensates in Transcriptional Regulation

, 2022
Transcriptional regulation of gene expression is fundamental in determining cell behavior, identity, and organism development. When dysregulated it can cause disease.
Coffey, Eliot L.
core  

Probing Nuclear HSATII Biomolecular Condensates

Human satellite sequence II (HSATII) is a tandemly repeated pericentric and heterochromatic sequence that is transcriptionally silent in normal human cells, yet in cancer cells HSATII RNA is aberrantly expressed and accumulates large nuclear foci that ...
Dube, Thembalami, , \u2724, Carone, Dawn M., Rabeler, Christina   +2 more
core   +1 more source