Results 81 to 90 of about 10,366 (238)

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets

Signal Transduction and Targeted Therapy
Cells orchestrate their processes through complex interactions, precisely organizing biomolecules in space and time. Recent discoveries have highlighted the crucial role of biomolecular condensates—membrane-less assemblies formed through the condensation
Soyoung Jeon, Yeram Jeon, Ji-Youn Lim, Yujeong Kim, Boksik Cha, Wantae Kim   +5 more
doaj   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Statistical mechanics models in protein association problems [PDF]

Doctor of PhilosophyDepartment of PhysicsJeremy D. SchmitProtein-Protein interactions can lead to disordered states such as precipitates or gels, or to ordered states such as crystals or microtubules.
Ramallo, Nelson Javier
core  

mRNA structure determines specificity of a polyQ-driven phase separation [PDF]

, 2018
Author Posting. © The Author(s), 2018. This is the author's version of the work. It is posted here by permission of American Association for the Advancement of Science for personal use, not for redistribution.
Crutchley, John M., Gerbich, Therese M., Ghanbari Niaki, Amirhossein, Gladfelter, Amy S., Langdon, Erin M., McLaughlin, Grace A., Myong, Sua, Qiu, Yupeng, Smith, Jean A., Termini, Christina M., Weeks, Kevin M., Weidmann, Chase   +11 more
core   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Reconfiguration of Multiphase Coacervate Droplets Into Self‐Regulated Nested Artificial Cells

Angewandte Chemie, EarlyView.
Living cells advance functionality through spatiotemporal sub‐compartmentalization and internal organization. Herein, we develop a self‐regulated artificial cell by transforming a membrane‐less multiphase coacervate droplet (MCD) into a membranized, structurally reinforced nested coacervate vesicle (NCV).
Zhuping Yin, Rui Sun, Jingxin Shao, Jan C. M. van Hest, Stephen Mann   +4 more
wiley   +2 more sources

Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates

Advanced Science, EarlyView.
This study utilizes microfluidics to quantify the nucleation rates of dense liquid phases within dilute solutions and of the reverse process, in which dilute voids nucleate inside condensates. The interfacial tension is identified as the key determinant of both processes.
Leif‐Thore Deck, Sandra Navarro Pacheco, Hannes Ausserwöger, Daan Frenkel, Nadia A. Erkamp, Tuomas P. J. Knowles   +5 more
wiley   +1 more source

Packaging biological cargoes in mesoporous materials: Opportunities for drug delivery [PDF]

, 2014
Introduction: Confinement of biomolecules in structured nanoporous materials offers several desirable features ranging from chemical and thermal stability, to resistance to degradation from the external environment.
Coppens, M-O, Karande, P, Siefker, J
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source