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Nature CommunicationsBiomolecular condensates play a central role in cellular processes by interacting with membranes driving wetting transitions and inducing mutual remodeling.
Agustín Mangiarotti +6 more
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Biomolecular condensates regulate cellular electrochemical equilibria
CellControl of the electrochemical environment in living cells is typically attributed to ion channels. Here, we show that the formation of biomolecular condensates can modulate the electrochemical environment in bacterial cells, which affects cellular processes globally. Condensate formation generates an electric potential gradient, which directly affects
Wen Yu, Javid P Mohammed, Lingchong You
exaly +4 more sources
Biomolecular Condensates and Cancer [PDF]
Cancer Cell, 2021 Malignant transformation is characterized by dysregulation of diverse cellular processes that have been the subject of detailed genetic, biochemical, and structural studies, but only recently has evidence emerged that many of these processes occur in the context of biomolecular condensates.
Boija, Ann +2 more
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Biomolecular condensates in cancer biology [PDF]
Cancer Science, 2021 AbstractUnderstanding the characteristics of cancer cells is essential for the development of improved diagnosis and therapeutics. From a gene regulation perspective, the super‐enhancer concept has been introduced to systematically understand the molecular mechanisms underlying the identities of various cell types and has been extended to the analysis ...
Hiroshi I. Suzuki, Koh Onimaru
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Focus on biomolecular condensates
The Plant Cell, 2023 descripción no proporcionada por ...
Emilio Gutierrez-Beltran +2 more
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Cell Reports, 2023 Summary: Membraneless organelles, or biomolecular condensates, enable cells to compartmentalize material and processes into unique biochemical environments. While specific, attractive molecular interactions are known to stabilize biomolecular condensates,
Michael D. Crabtree +11 more
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BRD4-targeting PROTAC as a unique tool to study biomolecular condensates
Cell Discovery, 2023 Biomolecular condensates play key roles in various biological processes. However, specific condensation modulators are currently lacking. PROTAC is a new technology that can use small molecules to degrade target proteins specifically.
Yi Shi +8 more
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Engineering synthetic biomolecular condensates
Nature Reviews Bioengineering, 2023 The concept of phase-separation-mediated formation of biomolecular condensates provides a new framework to understand cellular organization and cooperativity-dependent cellular functions. With growing understanding of how biological systems drive phase separation and how cellular functions are encoded by biomolecular condensates, opportunities have ...
Yifan Dai +2 more
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Biomolecular condensation involving the cytoskeleton
Brain Research Bulletin, 2023 Biomolecular condensation of proteins contributes to the organization of the cytoplasm and nucleoplasm. A number of condensation processes appear to be directly involved in regulating the structure, function and dynamics of the cytoskeleton. Liquid-liquid phase separation of cytoskeleton proteins, together with polymerization modulators, promotes ...
Satabdee Mohapatra, Susanne Wegmann
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Molecular structure in biomolecular condensates [PDF]
Current Opinion in Structural Biology, 2020 Evidence accumulated over the past decade provides support for liquid-liquid phase separation as the mechanism underlying the formation of biomolecular condensates, which include not only membraneless organelles such as nucleoli and RNA granules, but additional assemblies involved in transcription, translation and signaling. Understanding the molecular
Ivan Peran, Tanja Mittag
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