Results 31 to 40 of about 116,047 (273)
Artificial biomolecular condensates [PDF]
Nature Methods, 2018 Synthetic small molecules can form liquid-phase condensates and simultaneously sequester intracellular enzymes.
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Nucleation landscape of biomolecular condensates
Nature, 2021 All structures within living cells must form at the right time and place. This includes condensates such as the nucleolus, Cajal bodies and stress granules, which form via liquid-liquid phase separation of biomolecules, particularly proteins enriched in intrinsically disordered regions (IDRs)1,2.
Shimobayashi, Shunsuke +4 more
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mSphere, 2019 The social amoeba Dictyostelium discoideum’s proteome contains a vast array of simple sequence repeats, providing a unique model to investigate proteostasis. Upon conditions of cellular stress, D.
Stephanie Santarriaga +3 more
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The exchange dynamics of biomolecular condensates
eLife, 2022 Abstract A hallmark of biomolecular condensates formed via liquid-liquid phase separation is that they dynamically exchange material with their surroundings, and this process can be crucial to condensate function. Intuitively, the rate of exchange can be limited by the flux from the dilute phase or by the mixing speed in the dense phase.
Yaojun Zhang +6 more
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Getting ready for DNA duplication
eLife, 2019 The discovery of a biomolecular condensate involved in DNA replication has wide-ranging implications.
Nina Y Yao, Michael E O'Donnell
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When two became three: Shaping the nucleolus with Treacle
Cell Reports, 2023 The nucleolus is a multiphase biomolecular condensate responsible for the initial steps of ribosome biogenesis. Jaberi-Lashkari et al.1 report that Treacle, a protein associated with a craniofacial distortion disease, played an evolutionary role in the ...
Denis L.J. Lafontaine
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Molecular and environmental determinants of biomolecular condensate formation
, 2022 Biomolecular condensate formation has been implicated in a host of biological processes and has found relevance in biology and disease. Understanding the physical principles and underlying characteristics of how these macromolecular assemblies form and ...
Villegas, José A. +2 more
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Phase separation & interfacial phenomena of a model biomolecular condensate [PDF]
, 2022 The organization of intracellular space into distinct, membraneless, compartments is a ubiquitous feature of living organisms. It has recently become apparent that many of these biomolecular condensates may be formed by liquid-liquid phase separation ...
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Biomolecular condensates in autophagy regulation
Current Opinion in Cell Biology, 2021 Autophagy is an intracellular degradation system that contributes to cellular homeostasis. Autophagosome formation is a landmark event in autophagy, which sequesters and delivers cytoplasmic components to the lysosome for degradation. Based on selectivity, autophagy can be classified into bulk and selective autophagy, which are mechanistically distinct
Yuko, Fujioka, Nobuo N, Noda
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Allostery in Biomolecular Condensates
Journal of Molecular BiologyAllosteric proteins and membrane-less biomolecular condensates are physics-governed pivotal functional components. Allosteric regulation is an inherent physical property of dynamic proteins, and dynamic proteins are allosteric. Thus, in biomolecular condensates (like everywhere else in the cell), allostery is at play, and often missing in condensate ...
Ruth Nussinov, Clil Regev, Hyunbum Jang
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