Results 41 to 50 of about 143,872 (300)
Biomolecules, 2021 Biomolecular condensates, which assemble via the process of liquid–liquid phase separation (LLPS), are multicomponent compartments found ubiquitously inside cells.
Ignacio Sanchez-Burgos +3 more
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Biomolecular Condensates in the Nucleus [PDF]
Trends in Biochemical Sciences, 2020 Nuclear processes such as DNA replication, transcription, and RNA processing each depend on the concerted action of many different protein and RNA molecules. How biomolecules with shared functions find their way to specific locations has been assumed to occur largely by diffusion-mediated collisions.
Benjamin R. Sabari +2 more
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Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders
Antioxidants, 2021 Biomolecular condensates are membraneless organelles (MLOs) that form dynamic, chemically distinct subcellular compartments organizing macromolecules such as proteins, RNA, and DNA in unicellular prokaryotic bacteria and complex eukaryotic cells ...
Doris Loh, Russel J. Reiter
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Involvement of small molecules and metabolites in regulation of biomolecular condensate properties.
Current opinion in plant biology, 2023 Biomolecular condensate (BMCs) formation facilitates the grouping of molecules, including proteins, nucleic acids, and small molecules, creating specific microenvironments with particular functions.
I. Maruri-López, Monika Chodasiewicz
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Protein conformation and biomolecular condensates
Current Research in Structural Biology, 2022 Protein conformation and cell compartmentalization are fundamental concepts and subjects of vast scientific endeavors. In the last two decades, we have witnessed exciting advances that unveiled the conjunction of these concepts. An avalanche of studies highlighted the central role of biomolecular condensates in membraneless subcellular ...
Diego S. Vazquez +3 more
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Controlling biomolecular condensates via chemical reactions [PDF]
Journal of The Royal Society Interface, 2021 Biomolecular condensates are small droplets forming spontaneously in biological cells through phase separation. They play a role in many cellular processes, but it is unclear how cells control them. Cellular regulation often relies on post-translational modifications of proteins. For biomolecular condensates, such chemical modifications could alter the
Jan Kirschbaum, David Zwicker
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Nucleation landscape of biomolecular condensates
Nature, 2021 All structures within living cells must form at the right time and place. This includes condensates such as the nucleolus, Cajal bodies and stress granules, which form via liquid-liquid phase separation of biomolecules, particularly proteins enriched in intrinsically disordered regions (IDRs)1,2.
Shimobayashi, Shunsuke +4 more
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Artificial biomolecular condensates [PDF]
Nature Methods, 2018 Synthetic small molecules can form liquid-phase condensates and simultaneously sequester intracellular enzymes.
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Principles and functions of condensate modifying drugs
Frontiers in Molecular Biosciences, 2022 Biomolecular condensates are compartmentalized communities of biomolecules, which unlike traditional organelles, are not enclosed by membranes. Condensates play roles in diverse cellular processes, are dysfunctional in many disease states, and are often ...
Avinash Patel +5 more
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Topological Considerations in Biomolecular Condensation
Biomolecules, 2023 Biomolecular condensation and phase separation are increasingly understood to play crucial roles in cellular compartmentalization and spatiotemporal regulation of cell machinery implicated in function and pathology. A key aspect of current research is to gain insight into the underlying physical mechanisms of these processes.
Debapriya Das, Ashok A. Deniz
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