Results 41 to 50 of about 116,047 (273)

Fundamental Aspects of Phase-Separated Biomolecular Condensates [PDF]

Biomolecular condensates, formed through phase separation, are upending our understanding in much of molecular, cell, and developmental biology. There is an urgent need to elucidate the physicochemical foundations of the behaviors and properties of ...
Huan-Xiang, Zhou, Sanbo, Qin, Ramesh, Prasad, Divya, Kota   +3 more
core   +2 more sources

Decoding biomolecular condensate dynamics: an energy landscape approach. [PDF]

PLoS Comput Biol
Many eukaryotic proteins and RNAs contain low-complexity domains (LCDs) with a strong propensity for binding and driving phase separation into biomolecular condensates.
Biswas S, Potoyan DA.
europepmc   +2 more sources

Nfix Phase Separation Underlies Potential Mechanisms Of Craniofacial Abnormalities

International Dental Journal
Aim or purpose: This study explores alternative regulatory mechanisms of NFIX in Marshall-Smith syndrome (characterized by midface hypoplasia and micrognathia) and Malan syndrome (marked by macrocephaly and frontal bossing), hypothesizing that their ...
Jiayi Wang, Chenchen Zhou
doaj   +1 more source

Pre-assembly of biomolecular condensate seeds drives RSV replication. [PDF]

Nature
During infection, many RNA viruses, including respiratory syncytial virus (RSV), form specialized biomolecular condensates, viral factories (VFs), where viral transcription and replication occur1,2.
Ratnayake D, Galloux M, Boersma S, Noerenberg M, Sizun C, Sacristan C, Sourimant J, Lakerveld AJ, Gelderloos AT, Apperloo L, Demyanenko Y, Baars MJD, Banerjee R, Dreier B, Furler S, Mazur NI, Bont LJ, Mohammed S, Plückthun A, Éléouët JF, Kops GJPL, Castello A, van Kasteren PB, Rameix-Welti MA, Tanenbaum ME.   +24 more
europepmc   +2 more sources

The mechanobiology of biomolecular condensates

Biophysics Reviews
The central goal of mechanobiology is to understand how the mechanical forces and material properties of organelles, cells, and tissues influence biological processes and functions. Since the first description of biomolecular condensates, it was hypothesized that they obtain material properties that are tuned to their functions inside cells. Thus, they
Neus Sanfeliu-Cerdán, Michael Krieg
openaire   +2 more sources

Enhanced condensate fluidity in modified patchy particle models [PDF]

Biomolecular condensates are formed via liquid–liquid phase separation of proteins, often together with nucleic acids, typically driven by interactions between low-affinity binding sites. The computational study of such condensates that accounts for both
Dannenberg, Simon, Magan, Devika, Taskina, Alena, Klumpp, Stefan   +3 more
core   +5 more sources

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA-binding domain

eLife, 2021
Aberrant liquid-to-solid phase transitions of biomolecular condensates have been linked to various neurodegenerative diseases. However, the underlying molecular interactions that drive aging remain enigmatic.
Edgar E Boczek, Julius Fürsch, Marie Laura Niedermeier, Louise Jawerth, Marcus Jahnel, Martine Ruer-Gruß, Kai-Michael Kammer, Peter Heid, Laura Mediani, Jie Wang, Xiao Yan, Andrej Pozniakovski, Ina Poser, Daniel Mateju, Lars Hubatsch, Serena Carra, Simon Alberti, Anthony A Hyman, Florian Stengel   +18 more
doaj   +1 more source

Mechanisms of active regulation of biomolecular condensates [PDF]

Trends in Cell Biology, 2019
Abstract Liquid-liquid phase separation is a key organizational principle in eukaryotic cells, on par with intracellular membranes. It allows cells to concentrate specific proteins into condensates, increasing reaction rates and achieving switch-like regulation.
Söding, Johannes, Zwicker, David, Sohrabi-Jahromi, Salma, Boehning, Marc, Kirschbaum, Jan   +4 more
openaire   +5 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Phase behaviour and structure of a model biomolecular condensate

, 2020
Phase separation of immiscible fluids is a common phenomenon in polymer chemistry, and is recognized as an important mechanism by which cells compartmentalize their biochemical reactions.
Ipsen, J. H., Brochut, M., Shillcock, J. C., Chenais, E., Shillcock JC, Ipsen JH, Chénais E, Brochut M   +7 more
core   +2 more sources