Results 61 to 70 of about 116,047 (273)

Critical Capillary Waves of Biomolecular Condensates

PRX Life, 2023
Biomolecular condensates formed by phase separation are key players in cellular organization, yet their interfacial mechanics remain poorly understood. Here we show that both synthetic and endogenous nuclear condensates exhibit critical-like interfacial behaviors near the phase boundary, including enhanced capillary fluctuations and reduced surface ...
Shunsuke F. Shimobayashi, Paul J. Ackerman, Tomo Kurimura, Takashi Taniguchi, Clifford P. Brangwynne   +4 more
openaire   +1 more source

The Effect of Hydrophilic Headgroup Chemistry on Peptoid‐Directed Mineralization of CaCO3

Advanced Functional Materials, EarlyView.
Amphiphilic peptoids alter the pathway and outcome of calcium carbonate crystallization, which progresses through amorphous calcium carbonate (ACC) to vaterite to calcite rhombs in the absence of peptoids. In contrast, amine‐terminated peptoids produce vaterite disks and carboxyl‐terminated peptoids produce calcite mesocrystals.
Biao Jin, Chunhui Wu, Thi Kim Hoang Trinh, Wenhao Zhou, Chun‐Long Chen, James J De Yoreo   +5 more
wiley   +1 more source

PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms

Nature Communications
Biomolecular condensates are membraneless organelles that can concentrate hundreds of different proteins in cells to operate essential biological functions.
Anna Hadarovich, Hari Raj Singh, Soumyadeep Ghosh, Maxim Scheremetjew, Nadia Rostam, Anthony A. Hyman, Agnes Toth-Petroczy   +6 more
doaj   +1 more source

Chaperone regulation of biomolecular condensates

Frontiers in Biophysics
Biomolecular condensation allows for the dynamic organization of molecules in time and space. Condensate formation is regulated through many mechanisms including the action of molecular chaperones. While molecular chaperones have long been viewed through the lens of their roles in protein folding, misfolding, and quality control, their ability to ...
Bard, Jared A. M., Drummond, D. Allan
openaire   +3 more sources

Utilizing the Metastability of Spidroins as a Strategy for Improving Mechanical Properties of Biomimetic Spider Silk Fibers

Advanced Functional Materials, EarlyView.
Phase transitions are central for the assembly of recombinant silk proteins into fibers. Soluble protein can transition into condensed states such as condensates and gels. These states are metastable and evolve in a time‐dependent way. Metastability depends on the protein sequence, and this relationship can be used to enhance the mechanical properties ...
Fred‐Eric Sammalisto, Topias Lankinen, Celine Tallroth, Rafael A. Lara, Matilda Backholm, Markus B. Linder   +5 more
wiley   +1 more source

Oxygen depletion in biomolecular condensates is dominated by macromolecular density

Nature Communications
Biomolecular condensates are dynamic cellular compartments formed by the self-assembly of proteins and nucleic acids. Many metabolites partition into condensates based on their interactions with the macromolecular constituents; yet, whether gases behave ...
Ankush Garg, Christopher Brasnett, Siewert J. Marrink, Klaus Koren, Magnus Kjaergaard   +4 more
doaj   +1 more source

Do polyproline II helix associations modulate biomolecular condensates?

FEBS Open Bio, 2021
Biomolecular condensates are microdroplets that form inside cells and serve to selectively concentrate proteins, RNAs and other molecules for a variety of physiological functions, but can contribute to cancer, neurodegenerative diseases and viral ...
Miguel Mompeán, Javier Oroz, Douglas V. Laurents   +2 more
doaj   +1 more source

Emerging Roles of Ubiquitination in Biomolecular Condensates

Cells, 2023
Biomolecular condensates are dynamic non-membrane-bound macromolecular high-order assemblies that participate in a growing list of cellular processes, such as transcription, the cell cycle, etc. Disturbed dynamics of biomolecular condensates are associated with many diseases, including cancer and neurodegeneration.
Peigang Liang, Jiaqi Zhang, Bo Wang
openaire   +3 more sources

Selenium‐Integrated Cyanine Dye With Enhanced Photophysical Properties for Optoacoustic‐Guided Cancer Imaging and Therapy

Advanced Functional Materials, EarlyView.
This study introduces selenium‐integrated cyanine dye (Se‐Cyn), with superior photostability, absorption, and photothermal efficiency, outperforming ICG in NIR window. Its nanoparticle form remains stable in water, accumulates in tumors, and enables strong optoacoustic imaging and effective phototherapy outcomes.
Divyesh Shelar, Snehal Salunkhe, Tony Fröhlich, Uwe Klemm, Pia Anzenhofer, Birgit Rathkolb, Martin Hrabě de Angelis, Oliver Plettenburg, Michael Sattler, Sudesh T. Manjare, Vipul Gujrati, Vasilis Ntziachristos   +11 more
wiley   +1 more source

Pulsed Laser‐Assisted Phase Engineering of Multimetallic Colloidal Nanocrystals With Complex Compositions

Advanced Materials, EarlyView.
The engineering of colloidal nanocrystals with complex compositions has emerged as a highly active area of research within nanomaterials science. This review covers key aspects of colloidal solid‐solution nanocrystal formation using pulsed laser irradiation.
Marina T. Candela, Sergio Triviño‐Sánchez, Andrés Guerrero‐Martínez, Luis M. Liz‐Marzán, Guillermo González‐Rubio   +4 more
wiley   +1 more source