Results 71 to 80 of about 116,047 (273)

Linking Biomolecular Condensates to Disease and Therapeutic Development

, 2023
The cell is compartmentalized into membrane-bound and membraneless organelles that organize and regulate key cellular functions. Over the past decade, growing evidence supports the notion that membraneless organelles, called biomolecular condensates ...
Hawken, Susana W.
core  

CD-CODE: crowdsourcing condensate database and encyclopedia

, 2023
The discovery of biomolecular condensates transformed our understanding of intracellular compartmentalization of molecules. To integrate interdisciplinary scientific knowledge about the function and composition of biomolecular condensates, we developed ...
Moon, H., Diana M. Mitrea, Nadia Rostam, Soumyadeep Ghosh, Landerer, C., Toth-Petroczy, A., Hadarovich, A., Ghosh, S., Ghosh, R., Hersemann, L., Mitrea, D., Anthony A. Hyman, Cedric Landerer, Chow, C., Agnes Toth-Petroczy, Anna Hadarovich, Klein, I., HongKee Moon, Rajat Ghosh, Lena Hersemann, Hyman, A., Rostam, N., Isaac A. Klein, Chi Fung Willis Chow   +23 more
core   +1 more source

Understanding Operando Water Management in Hydroxide‐Exchange‐Membrane Fuel Cells

Advanced Materials Interfaces, EarlyView.
Effective water management is vital for high‐performance hydroxide‐exchange‐membrane fuel cells. Using a custom water‐flux station, this study quantifies how membrane thickness, microporous layers, and operating conditions dictate internal water transport.
Catherine M. Weiss, Shiyi Wang, Brian P. Setzler, Yushan Yan, Adam Z. Weber   +4 more
wiley   +1 more source

Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-β-sheet formation

Nature Communications
Biomolecular condensates play wide-ranging roles in cellular compartmentalization and biological processes. However, their transition from a functional liquid-like phase into a solid-like state—usually termed as condensate ageing—represents a hallmark ...
Ignacio Sanchez-Burgos, Andres R. Tejedor, Alejandro Castro, Alejandro Feito, Rosana Collepardo-Guevara, Jorge R. Espinosa   +5 more
doaj   +1 more source

Interface Dynamics in Biomolecular Condensates by High‐Speed AFM

Advanced Materials Interfaces, EarlyView.
High‐speed atomic force microscopy provides nanoscale structural dynamics at the liquid interface of biomolecular condensates, key elements in several cellular pathways. By addressing the challenges of low surface tension and condensate‐induced instabilities, we achieve nanometer spatial and sub‐second temporal resolution, revealing structural ...
Andreas Santamaria, Nessim Louafi, Isabelle Alakiki, Stephanie Hutin, Chloe Zubieta, Pierre‐Emmanuel Milhiet, Luca Costa   +6 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Defining the condensate landscape of fusion oncoproteins

, 2023
Fusion oncoproteins (FOs) arise from chromosomal translocations in ~17% of cancers and are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing liquid-liquid phase separation (LLPS) to form aberrant biomolecular condensates ...
Diana M. Mitrea, S. Stephen Yi, Xin Zhou, David W. Baggett, Swarnendu Tripathi, Benjamin Lang, Charles G. Mullighan, Cheon-Gil Park, Brittany J. Pioso, Qingsong Gao, Daniel F. Jarosz, Jinghui Zhang, Hazheen K. Shirnekhi, Ramiz Somjee, Yongsheng Li, Michael N. Edmonson, Seyed Mohammad Hadi Hosseini, M. Madan Babu, Scott D. Gorman, Richard W. Kriwacki, Nidhi Sahni, John Bollinger, Michael R. White, Bappaditya Chandra, Stephen V. Rice, Ilaria Iacobucci, Daniel J. McGrail   +26 more
core   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

The role of membrane-biomolecular condensate interactions in stress [Elektronisk resurs]

Biomolecules can be condensed through liquid-liquid phase separation (LLPS) or other material states. The resulting biomolecular condensates can play key roles in cellular organisation and stress responses.
Sveriges lantbruksuniversitet., Moschou, Panagiotis Nikolaou,, Kutashev, Konstantin,, Swedish University of Agricultural Sciences.   +3 more
core   +1 more source

Lipid‐Mediated DNA–Protein Coupling Reinforces the Mechanics of HP1α–DNA Condensates

Small Science
Biomolecular condensates formed via liquid–liquid phase separation often contain multiple molecular components whose collective interactions determine their physical properties.
Masato Machida, Kohei Yokosawa, Shinya Tahara, Takakazu Nakabayashi, Shinji Kajimoto   +4 more
doaj   +1 more source