Results 81 to 90 of about 116,047 (273)

Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates

Scientific Reports, 2022
Biomolecular condensates formed by the process of liquid–liquid phase separation (LLPS) play diverse roles inside cells, from spatiotemporal compartmentalisation to speeding up chemical reactions.
Adiran Garaizar, Jorge R. Espinosa, Jerelle A. Joseph, Rosana Collepardo-Guevara   +3 more
doaj   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Spectrin condensates provide a nidus for assembling the axonal membrane-associated periodic skeleton

iScience
Summary: In axons, α/β-spectrins, adducin, and actin filaments assemble into a lattice underneath the plasma membrane, but the mechanistic events leading to this membrane-associated periodic skeleton (MPS) are unclear.
Nicholas P. Boyer, Rohan Sharma, Theresa Wiesner, Christopher Parperis, Antoine Delamare, Florence Pelletier, Nicolas Jullien, Anshul M. Bhatt, Leonardo A. Parra-Rivas, Patrick J. Kearney, Farbod Shavarebi, Christophe Leterrier, Subhojit Roy   +12 more
doaj   +1 more source

The role of membrane-biomolecular condensate interactions in stress [PDF]

Biomolecules can be condensed through liquid-liquid phase separation (LLPS) or other material states. The resulting biomolecular condensates can play key roles in cellular organisation and stress responses.
Moschou, Panagiotis Nikolaou
core  

The Effects of DEAD-box Helicase Activity on Biomolecular Condensate Structure and Dynamics

, 2023
Biomolecular condensates are membraneless organelles which help spatiotemporally organize the biochemistry of the cytoplasm and nucleoplasm. These bodies are composed of specific proteins and RNA which self-associate to drive condensate formation.
Coupe, Sebastian
core  

Tuning the state: Matching condensate material properties with physiological demands and pathological dysfunction

Cell Insight
Biomolecular condensates have emerged as fundamental organizers of cellular biochemistry. Increasing evidence indicates that cellular condensates exhibit a broad spectrum of material properties—including viscoelastic, soft glass-like, gel-like, and quasi-
Jingxuan Luo, Zhehao Li, Ziyin Shen, Xiaoyu Zhai, Jiayue Chen, Hanchun Wang, Xueping Zhao, Jing He, Mingrui Ding   +8 more
doaj   +1 more source

Sticker Valence Governs Chain Collapse and Liquid‐Liquid Phase Separation in Peptide‐Inspired Associative Polymers

Advanced Science, EarlyView.
Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh, Jinhoon Lee, Seunghyun Lee, Raehyun Jung, Sangyeop Lee, Su‐Mi Hur, Dong Woog Lee, Soo‐Hyung Choi   +7 more
wiley   +1 more source

BioMolecular Sciences [PDF]

, 2021
Presenter: Department of BioMolecular Scienceshttps://egrove.olemiss.edu/pharm_annual_posters_2021/1006/thumbnail ...
University of Mississippi. Department of BioMolecular Sciences
core  

Uncovering protein conformational dynamics within two-component viral biomolecular condensates. [PDF]

Biomolecular condensates selectively compartmentalize and organize biomolecules within the crowded cellular milieu and are instrumental in some disease mechanisms.
Calabrese, A.N., Borodavka, A., Colyer, A., Acker, J., Acker, Julia, Calabrese, Antonio N., Borodavka, Alexander, Colyer, Alice   +7 more
core   +5 more sources

Protein modifications and ionic strength show the difference between protein-mediated and solvent-mediated regulation of biomolecular condensation

Frontiers in Nanotechnology
Biomolecular condensation is an important mechanism of cellular compartmentalization without membranes. Formation of liquid-like condensates of biomolecules involves protein-protein interactions working in tandem with protein-water interactions.
Artur Czajkowski, Artur Czajkowski, Abhirami Udayabanu, Abhirami Udayabanu, Manthan Raj, Manthan Raj, Likhitha Ch. P. Pulibandla, Likhitha Ch. P. Pulibandla, Marija Tursunović, Marcus Jahnel, Marcus Jahnel, Ellen M. Adams, Ellen M. Adams   +12 more
doaj   +1 more source