Results 91 to 100 of about 116,047 (273)

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Scaffold Affinity Tunes Biomolecular Condensate Function

Biomolecular condensates (BMCs) organize cellular biochemistry by concentrating selected molecules into dynamic membrane-free compartments. Yet the molecular parameters that determine not only whether condensates form, but also how they behave and what ...
Madyson O Briggs, Alexander Russell, Thomas R Hinds, NIng Zheng, Ryan J Wang, Andres Reyna, Reuben Allen, Tien M Phan, Jeetain Mittal, Champak Chatterjee   +9 more
core   +1 more source

Functional specificity in biomolecular condensates revealed by genetic complementation [PDF]

Biomolecular condensates are thought to create subcellular microenvironments that regulate specific biochemical activities. Extensive in vitro work has helped link condensate formation to a wide range of cellular processes, including gene expression ...
Hnisz, D. ; https://orcid.org/, Sabari, B., Hyman, A., Hnisz, D.   +3 more
core   +1 more source

Full‐Length FUS Protein Condensates Adopt a Domain‐Preferential Spatial Architecture

Aggregate
Biomolecular condensates play crucial roles in cellular physiology and are implicated in neurodegenerative diseases and cancer. However, the mechanisms governing their formation and spatial organization remain poorly understood, largely due to technical ...
Si‐Cheng Tong, Yang Jiang, Yi‐Nan Guo, Yong Wang, Li Zhao, Zhong‐Yuan Lu   +5 more
doaj   +1 more source

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

Modeling biomolecular condensates across scales: atomistic, coarse-grained, and data-driven approaches

Advances in Physics: X
Biomolecular condensates are integral to processes underlying cellular function and dysfunction, and they also present a versatile platform for engineering living cells.
M. Julia Maristany, Alina Emelianova, Pin Yu Chew, Anne Aguirre, Rosana Collepardo-Guevara, Jerelle A. Joseph   +5 more
doaj   +1 more source

Biomolecular condensates in plant immunity

Cell Host & Microbe
Plant defense against microbial pathogens relies on coordinated regulation of diverse molecular processes. Although much has been learned about these processes through traditional and modern approaches, recent findings indicate that they are orchestrated through membraneless biomolecular condensates formed via liquid-liquid phase separation and related
Shuai Huang, Xinnian Dong
openaire   +2 more sources

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

AI‐Powered, Temperature‐Resolved Centrifugal Microfluidics for Rapid 3D Phase‐Diagram Generation of Biomolecular Condensates

Advanced Science, EarlyView.
By merging centrifugal microfluidics, precise temperature control, and AI image recognition, T‐PhaseMap transforms biomolecular condensate phase mapping into a rapid, temperature‐resolved workflow. It generates 3D composition–temperature phase diagrams within 30 min, resolves four phase states, and uncovers temperature‐dependent heparin sodium ...
Jiashuo Li, Pengjie Li, Kaiting Zhang, Yongqi Guo, Peng Chen, Bi‐Feng Liu, Yiwei Li   +6 more
wiley   +1 more source

Imprinting a topological interface using Zeeman shifts in an atomic spinor Bose–Einstein condensate [PDF]

, 2014
We propose to use spatial control of the Zeeman energy shifts in an ultracold atomic gas to engineer an interface between topologically distinct regions.
Borgh, Magnus O, Lovegrove, J, Ruostekoski, J, Borgh, Magnus O., Lovegrove, Justin, Ruostekoski, Janne   +5 more
core   +1 more source