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Liquid–liquid phase separation in neural development [PDF]
Cellular and Molecular Life SciencesLiquid–liquid phase separation (LLPS) is a physicochemical process in which a homogeneous mixture of molecules separates into a denser phase originating from preferential self-assembly, driven by multivalent interactions, frequently mediated by ...
Sara Surini, Ivan de Curtis
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Liquid–liquid phase separation by caged coacervating peptides [PDF]
Scientific ReportsLiquid–liquid phase separation is an important biomolecular process in the formation of membraneless intracellular organelles that has inspired the development of artificial droplet systems.
Akinari Bando +5 more
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Liquid-Liquid Phase Separation in an Elastic Network
Physical Review X, 2018 Living and engineered systems rely on the stable coexistence of two interspersed liquid phases. Yet, surface tension drives their complete separation. Here, we show that stable droplets of uniform and tunable size can be produced through arrested phase ...
Robert W. Style +7 more
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Visualizing liquid-liquid phase separation and protein aggregates [PDF]
Communications ChemistryLiquid-liquid phase separation (LLPS) facilitates functionally-relevant proteins to gather in high concentrations at specific locations. Several interacting proteins encapsulated in the membraneless droplets tend to form abnormal protein aggregates which
Jing Xue +5 more
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Liquid–Liquid Phase Separation in Viral Infection and Immunology [PDF]
MedCommLiquid–liquid phase separation (LLPS) has emerged as a fundamental physicochemical principle that organizes macromolecules into dynamic, membraneless condensates.
Jiuzhi Xu +5 more
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Competition Between Liquid‐Liquid Crystalline Phase Separation (LLCPS) and Liquid‐Liquid Phase Separation (LLPS) in Amyloid Fibril Colloidal Systems [PDF]
Advanced ScienceAmyloid fibrils are rigid, elongated protein aggregates that form condensed phases in functional biological assemblies and pathological deposits. From a colloidal physics perspective, two separation pathways can lead to these condensed phases: liquid ...
Milad Radiom, Raffaele Mezzenga
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Artificial Metalloenzymes in Artificial Sanctuaries Through Liquid–Liquid Phase Separation [PDF]
Bio-ProtocolArtificial metalloenzymes (ArMs) hold great promise for expanding the toolbox of non-natural transformations usable in living systems, such as cells, plants, and animals.
Kaixin Wang +4 more
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Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis [PDF]
Cell Death DiscoverySepsis is a life-threatening condition characterized by overactivated inflammation and a dysregulated immune response caused by infection. The predominant mechanism underlying the vulnerability and severity of sepsis has not been fully elucidated. Liquid‒
Huiyi Chen +8 more
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RNA and liquid-liquid phase separation
Non-coding RNA Research, 2021 Liquid-Liquid Phase Separation (LLPS) is a biological phenomenon that refers to the components of similar properties form droplets condensate in cells. These droplets play an important role in maintaining the stability of order in cells.
Qi Guo, Xiangmin Shi, Xiangting Wang
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Liquid–liquid phase separation in synaptopathies
Neuroprotection, 2023 Liquid–liquid phase separation has emerged as an important mechanism for regulating cell activity by promoting the formation of membrane‐less condensates.
Huihui Jiang, Haitao Wu
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