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Liquid–liquid phase separation in neural development [PDF]

Cellular and Molecular Life Sciences
Liquid–liquid phase separation (LLPS) is a physicochemical process in which a homogeneous mixture of molecules separates into a denser phase originating from preferential self-assembly, driven by multivalent interactions, frequently mediated by ...
Sara Surini, Ivan de Curtis
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Liquid–liquid phase separation by caged coacervating peptides [PDF]

Scientific Reports
Liquid–liquid phase separation is an important biomolecular process in the formation of membraneless intracellular organelles that has inspired the development of artificial droplet systems.
Akinari Bando, Mizuki Kitamatsu, Yuuki Kanazaki, Rika Tojo, Kazunori Watanabe, Takashi Ohtsuki   +5 more
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Liquid–Liquid Phase Separation in Viral Infection and Immunology [PDF]

MedComm
Liquid–liquid phase separation (LLPS) has emerged as a fundamental physicochemical principle that organizes macromolecules into dynamic, membraneless condensates.
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
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MORC2 mediates transcriptional regulation through liquid-liquid phase separation [PDF]

eLife
MORC2 is a chromatin-associated ATPase essential for transcriptional silencing and genome stability, yet the biophysical principles governing its regulatory activity remain elusive.
Yanshen Zhang, Weiya Xu, Wenxiu Duan, Yu Wei, Wenli Jiang, Feng Zhu, Chengdong Huang, Chao Wang, Yihui Bi   +8 more
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Visualizing liquid-liquid phase separation and protein aggregates [PDF]

Communications Chemistry
Liquid-liquid phase separation (LLPS) facilitates functionally-relevant proteins to gather in high concentrations at specific locations. Several interacting proteins encapsulated in the membraneless droplets tend to form abnormal protein aggregates which
Jing Xue, Xiao-Wen Cao, Xiu-Lan Jia, Xi Chen, Wei-Hong Guo, Da-Chuan Yin   +5 more
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Artificial Metalloenzymes in Artificial Sanctuaries Through Liquid–Liquid Phase Separation [PDF]

Bio-Protocol
Artificial metalloenzymes (ArMs) hold great promise for expanding the toolbox of non-natural transformations usable in living systems, such as cells, plants, and animals.
Kaixin Wang, Guangjie Zhang, Lei Zhang, Yugang Bai, Tong Wu   +4 more
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RNA and liquid-liquid phase separation

Non-coding RNA Research, 2021
Liquid-Liquid Phase Separation (LLPS) is a biological phenomenon that refers to the components of similar properties form droplets condensate in cells. These droplets play an important role in maintaining the stability of order in cells.
Qi Guo, Xiangmin Shi, Xiangting Wang
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Liquid–liquid phase separation in synaptopathies

Neuroprotection, 2023
Liquid–liquid phase separation has emerged as an important mechanism for regulating cell activity by promoting the formation of membrane‐less condensates.
Huihui Jiang, Haitao Wu
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Liquid–Liquid Phase Separation in Cardiovascular Diseases

Cells, 2022
Liquid–liquid phase separation (LLPS) is a biochemical process in cells that can drive proteins, RNA, and other molecules to concentrate into droplets.
Yuanxi Mo, Yuliang Feng, Wei Huang, Ning Tan, Xinyi Li, Minwen Jie, Tong Feng, Hao Jiang, Lei Jiang   +8 more
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Open questions on liquid–liquid phase separation

Communications Chemistry, 2023
Liquid-liquid phase separation (LLPS) underlies the formation of intracellular membraneless compartments in biology and may have played a role in the formation of protocells that concentrate key chemicals during the origins of life.
Evan Spruijt
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