Results 41 to 50 of about 310,656 (114)

Tailoring Multiphasic Protein Condensates via Liquid‐Liquid Phase Separation

Aggregate
Many of the membraneless organelles inside cells are multiphasic condensates with complex structural organizations driven by the demixing of phase‐separating proteins.
Yongxu Han, Kai Cheng, Kongqi Chen, Zhiyi Xu, Hao Jiang, Bin Zeng, Manjia Li, Fei Sun, Xiangze Zeng, Sijie Chen, Jiang Xia   +10 more
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Liquid-liquid crystalline phase separation of spider silk proteins

Communications Chemistry
Liquid-liquid phase separation (LLPS) of proteins can be considered an intermediate solubility regime between disperse solutions and solid fibers.
Michael Landreh, Hannah Osterholz, Gefei Chen, Stefan D. Knight, Anna Rising, Axel Leppert   +5 more
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Yield of Protein Crystallization from Metastable Liquid–Liquid Phase Separation

Molecules
Preparative protein crystallization is regarded as an economically sustainable protein purification alternative to chromatography in biotechnological downstream processing. However, protein crystallization is a not-well-understood process that is usually
Shamberia Thomas, Joel A. Dougay, Onofrio Annunziata   +2 more
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Interplay Between Intracellular Transport Dynamics and Liquid‒Liquid Phase Separation

Advanced Science
Liquid‒liquid phase separation (LLPS) is a ubiquitous process in which proteins, RNA, and biomolecules assemble into membrane‐less compartments, playing important roles in many biological functions and diseases.
Ming‐Li Zhang, Ziheng Zhang, Xue‐Zhi Niu, Hui‐Ying Ti, Yu‐Xuan Zhou, Bo Gao, Yiwei Li, Ji‐Long Liu, Xiaosong Chen, Hui Li   +9 more
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An Overview of Liquid-Liquid Phase Separation and Its Mechanisms in Sepsis

Journal of Inflammation Research
Meiling Cao,1,* Xinyi Zhang,2,* Xiaohan Wang,2,* Danyang Zhao,2 Mingyue Shi,2 Jiahui Zou,2 Lei Li,3 Hongkun Jiang2 1Department of Neonatology, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, People’s Republic of ...
Cao M, Zhang X, Wang X, Zhao D, Shi M, Zou J, Li L, Jiang H   +7 more
doaj  

Bioinformatic approaches of liquid–liquid phase separation in human disease

Chinese Medical Journal
. Biomolecular aggregation within cellular environments via liquid–liquid phase separation (LLPS) spontaneously forms droplet-like structures, which play pivotal roles in diverse biological processes.
Jun Sun, Yilong Chen, Ruiye Bi, Yong Yuan, Haopeng Yu, Yuanyuan Ji   +5 more
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Liquid‒liquid phase separation: a potentially fundamental mechanism of sepsis

Cell Death Discovery
Sepsis is a life-threatening condition characterized by overactivated inflammation and a dysregulated immune response caused by infection. The predominant mechanism underlying the vulnerability and severity of sepsis has not been fully elucidated. Liquid‒
Huiyi Chen, Shunyi Huang, Longcheng Quan, Caiyuan Yu, Yang Zhu, Xiaocong Sun, Yuanli Zhang, Liehua Deng, Feng Chen   +8 more
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Role of liquid–liquid phase separation in cancer: Mechanisms and therapeutic implications

Cancer Innovation
Liquid–liquid phase separation (LLPS) has emerged as a pivotal biological phenomenon involved in various cellular processes, including the formation of membrane‐less organelles and the regulation of biomolecular condensates through precise spatiotemporal
Xuesong Li, Zhuo Yu
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Temperature-Controlled Liquid–Liquid Phase Separation of Disordered Proteins

ACS Central Science, 2019
Gregory L. Dignon, Wenwei Zheng, Young C. Kim, Jeetain Mittal   +3 more
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Liquid-liquid phase separation in cancer therapy resistance. [PDF]

iScience
Hu P, Ding H, Yue N, Ye J, Ruan S, Qian Y, Wang C, Song D.   +7 more
europepmc   +1 more source