Results 1 to 10 of about 342,327 (294)

RNA and liquid-liquid phase separation

Non-coding RNA Research, 2021
Liquid-Liquid Phase Separation (LLPS) is a biological phenomenon that refers to the components of similar properties form droplets condensate in cells. These droplets play an important role in maintaining the stability of order in cells.
Xiangting Wang, Qi Guo
exaly   +5 more sources

Liquid–liquid phase separation in synaptopathies

Neuroprotection, 2023
Liquid–liquid phase separation has emerged as an important mechanism for regulating cell activity by promoting the formation of membrane‐less condensates.
Huihui Jiang, Haitao Wu
doaj   +3 more sources

Open questions on liquid–liquid phase separation [PDF]

Communications Chemistry, 2023
Liquid-liquid phase separation (LLPS) underlies the formation of intracellular membraneless compartments in biology and may have played a role in the formation of protocells that concentrate key chemicals during the origins of life.
Evan Spruijt
doaj   +6 more sources

Biomolecular Liquid–Liquid Phase Separation for Biotechnology

BioTech, 2023
The liquid–liquid phase separation (LLPS) of biomolecules induces condensed assemblies called liquid droplets or membrane-less organelles. In contrast to organelles with lipid membrane barriers, the liquid droplets induced by LLPS do not have distinct ...
Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi, Daisuke Miyoshi   +3 more
doaj   +3 more sources

Liquid–Liquid Phase Separation in Cardiovascular Diseases

Cells, 2022
Liquid–liquid phase separation (LLPS) is a biochemical process in cells that can drive proteins, RNA, and other molecules to concentrate into droplets.
Yuanxi Mo, Yuliang Feng, Wei Huang, Ning Tan, Xinyi Li, Minwen Jie, Tong Feng, Hao Jiang, Lei Jiang   +8 more
doaj   +3 more sources

A Short Peptide Synthon for Liquid-Liquid Phase Separation [PDF]

Nature Chemistry, 2020
Liquid-liquid phase separation of disordered proteins has emerged as a ubiquitous route to membraneless compartments in living cells, and similar coacervates may have played a role when the first cells formed.
Evan, Spruijt, Wojciech P., Lipiński, Karina K., Nakashima, Wilhelm T.S., Huck, Manzar, Abbas   +4 more
core   +5 more sources

Liquid–liquid phase separation in tumor biology

Signal Transduction and Targeted Therapy, 2022
Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids into micron-scale, liquid-like, membraneless bodies with specific ...
Xuhui Tong, Rong Tang, Jin Xu, Wei Wang, Yingjun Zhao, Xianjun Yu, Si Shi   +6 more
doaj   +3 more sources

Liquid-liquid phase separation in neural development. [PDF]

Cell Mol Life Sci
Liquid–liquid phase separation (LLPS) is a physicochemical process in which a homogeneous mixture of molecules separates into a denser phase originating from preferential self-assembly, driven by multivalent interactions, frequently mediated by ...
Surini S, de Curtis I.
europepmc   +2 more sources

Liquid–liquid phase separation in diseases

MedComm
Liquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can sequester molecules to implement physiological and pathological functions.
Xinyue Zhang, Lin Yuan, Wanlu Zhang, Yi Zhang, Qun Wu, Chunting Li, Min Wu, Yongye Huang   +7 more
doaj   +3 more sources

Self-assembly coupled to liquid-liquid phase separation.

PLoS Computational Biology, 2023
Liquid condensate droplets with distinct compositions of proteins and nucleic acids are widespread in biological cells. While it is known that such droplets, or compartments, can regulate irreversible protein aggregation, their effect on reversible self ...
Michael F Hagan, Farzaneh Mohajerani
doaj   +3 more sources