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Open questions on liquid–liquid phase separation [PDF]
Communications Chemistry, 2023 Liquid-liquid phase separation (LLPS) underlies the formation of intracellular membraneless compartments in biology and may have played a role in the formation of protocells that concentrate key chemicals during the origins of life.
Evan Spruijt
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Biomolecular Liquid–Liquid Phase Separation for Biotechnology
BioTech, 2023 The liquid–liquid phase separation (LLPS) of biomolecules induces condensed assemblies called liquid droplets or membrane-less organelles. In contrast to organelles with lipid membrane barriers, the liquid droplets induced by LLPS do not have distinct ...
Sumit Shil +3 more
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Liquid–liquid phase separation in tumor biology
Signal Transduction and Targeted Therapy, 2022 Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids into micron-scale, liquid-like, membraneless bodies with specific ...
Xuhui Tong +6 more
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Self-assembly coupled to liquid-liquid phase separation.
PLoS Computational Biology, 2023 Liquid condensate droplets with distinct compositions of proteins and nucleic acids are widespread in biological cells. While it is known that such droplets, or compartments, can regulate irreversible protein aggregation, their effect on reversible self ...
Michael F Hagan, Farzaneh Mohajerani
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EFhd2 Affects Tau Liquid–Liquid Phase Separation [PDF]
Frontiers in Neuroscience, 2019 The transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in Alzheimer’s disease and related dementias, is poorly understood.
Irving E. Vega +6 more
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Liquid–liquid phase separation in human health and diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets).
Bin Wang +6 more
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Liquid–liquid phase separation within fibrillar networks
Nature Communications, 2023 Complex fibrillar networks mediate liquid–liquid phase separation of biomolecular condensates within the cell. Mechanical interactions between these condensates and the surrounding networks are increasingly implicated in the physiology of the condensates
Jason X. Liu +5 more
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When liquid-liquid phase separation meets viral infections
Frontiers in Immunology, 2022 Eukaryotic cells have both membranous and membraneless organelles. While the formation mechanism of membranous organelles is well understood, the formation mechanism of membraneless organelles remains unknown.
Wenqiang Wei +10 more
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Cells, 2022 Membrane-enclosed organelle compartmentalization is not the only way by which cell processes are spatially organized. Phase separation is emerging as a new driver in the organization of membrane-less compartments and biological processes.
Klizia Maccaroni +3 more
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Comprehensive Regulation of Liquid–Liquid Phase Separation of Polypeptides
Molecules, 2023 The elucidation of the molecular driving forces responsible for Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids within living cells is crucial for understanding its biological functions and its role in related diseases. In the present
Yanwei Wang +3 more
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