Results 11 to 20 of about 6,019,478 (263)
Biomolecular Liquid–Liquid Phase Separation for Biotechnology
BioTech, 2023 The liquid–liquid phase separation (LLPS) of biomolecules induces condensed assemblies called liquid droplets or membrane-less organelles. In contrast to organelles with lipid membrane barriers, the liquid droplets induced by LLPS do not have distinct ...
Sumit Shil +3 more
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Liquid–liquid phase separation in tumor biology
Signal Transduction and Targeted Therapy, 2022 Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids into micron-scale, liquid-like, membraneless bodies with specific ...
Xuhui Tong +6 more
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Liquid–liquid phase separation in diseases
MedCommLiquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can sequester molecules to implement physiological and pathological functions.
Xinyue Zhang +7 more
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Self-assembly coupled to liquid-liquid phase separation.
PLoS Computational Biology, 2023 Liquid condensate droplets with distinct compositions of proteins and nucleic acids are widespread in biological cells. While it is known that such droplets, or compartments, can regulate irreversible protein aggregation, their effect on reversible self ...
Michael F Hagan, Farzaneh Mohajerani
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A Short Peptide Synthon for Liquid-Liquid Phase Separation [PDF]
Nature Chemistry, 2020 Liquid-liquid phase separation of disordered proteins has emerged as a ubiquitous route to membraneless compartments in living cells, and similar coacervates may have played a role when the first cells formed.
Evan, Spruijt +4 more
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EFhd2 Affects Tau Liquid–Liquid Phase Separation [PDF]
Frontiers in Neuroscience, 2019 The transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in Alzheimer’s disease and related dementias, is poorly understood.
Irving E. Vega +6 more
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Liquid–liquid phase separation in human health and diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets).
Bin Wang +6 more
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Liquid–liquid phase separation in hepatocellular carcinoma
Frontiers in Cell and Developmental BiologyLiquid-liquid phase separation (LLPS) drives the formation of membraneless intracellular compartments within both cytoplasm and nucleus. These compartments can form distinct physicochemical environments, and in particular display different concentrations
Jianguo Xu +5 more
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Advanced modelling and visualisation of liquid-liquid separations of complex sample components, with variable phase distribution and mode of operation [PDF]
, 2013 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This research is about liquid-liquid chromatography modelling.
De Folter, Jozefus Johannes Martinus
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Liquid-liquid phase separation driven by charge heterogeneity
Communications PhysicsDespite the intrinsic charge heterogeneity of proteins plays a crucial role in the liquid-liquid phase separation (LLPS) of a broad variety of protein systems, our understanding of the effects of their electrostatic anisotropy is still in its early ...
Daniele Notarmuzi, Emanuela Bianchi
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