Results 11 to 20 of about 342,327 (294)

Liquid-liquid phase separation by caged coacervating peptides. [PDF]

Sci Rep
Liquid–liquid phase separation is an important biomolecular process in the formation of membraneless intracellular organelles that has inspired the development of artificial droplet systems.
Bando A, Kitamatsu M, Kanazaki Y, Tojo R, Watanabe K, Ohtsuki T.   +5 more
europepmc   +2 more sources

MORC2 mediates transcriptional regulation through liquid-liquid phase separation. [PDF]

Elife
MORC2 is a chromatin-associated ATPase essential for transcriptional silencing and genome stability, yet the biophysical principles governing its regulatory activity remain elusive.
Zhang Y, Xu W, Duan W, Wei Y, Jiang W, Zhu F, Huang C, Wang C, Bi Y.   +8 more
europepmc   +2 more sources

Liquid–liquid phase separation in hepatocellular carcinoma

Frontiers in Cell and Developmental Biology
Liquid-liquid phase separation (LLPS) drives the formation of membraneless intracellular compartments within both cytoplasm and nucleus. These compartments can form distinct physicochemical environments, and in particular display different concentrations
Jianguo Xu, Wangwang Liu, Yihan Yao, Tuomas P. J. Knowles, Zhi-Gang Zhang, Yan-Li Zhang   +5 more
doaj   +3 more sources

Liquid-Liquid Phase Separation in Viral Infection and Immunology. [PDF]

MedComm (2020)
Liquid–liquid phase separation (LLPS) has emerged as a fundamental physicochemical principle that organizes macromolecules into dynamic, membraneless condensates.
Xu J, Bai L, Wang B, Song H, Zhang L, Zhou F.   +5 more
europepmc   +2 more sources

Visualizing liquid-liquid phase separation and protein aggregates. [PDF]

Commun Chem
Liquid-liquid phase separation (LLPS) facilitates functionally-relevant proteins to gather in high concentrations at specific locations. Several interacting proteins encapsulated in the membraneless droplets tend to form abnormal protein aggregates which
Xue J, Cao XW, Jia XL, Chen X, Guo WH, Yin DC.   +5 more
europepmc   +2 more sources

EFhd2 Affects Tau Liquid–Liquid Phase Separation [PDF]

Frontiers in Neuroscience, 2019
The transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in Alzheimer’s disease and related dementias, is poorly understood.
Irving E. Vega, Irving E. Vega, Irving E. Vega, Andrew Umstead, Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan   +6 more
doaj   +3 more sources

Liquid–liquid phase separation in human health and diseases [PDF]

Signal Transduction and Targeted Therapy, 2021
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets).
Bin Wang, Lei Zhang, Tong Dai, Ziran Qin, Huasong Lu, Long Zhang, Fangfang Zhou   +6 more
doaj   +3 more sources

Three Liquid-Liquid Phase Separation-Related Genes Associated with Prognosis in Glioma [PDF]

Pharmacogenomics and Personalized Medicine
Ling Lv,1 Xin Zhang,1 Yajun Liu,1 Xutong Zhu,2 Ruihan Pan,1 Lifa Huang1 1Department of Neurosurgery, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, People’s ...
Lv L, Zhang X, Liu Y, Zhu X, Pan R, Huang L   +5 more
doaj   +2 more sources

Artificial Metalloenzymes in Artificial Sanctuaries Through Liquid-Liquid Phase Separation. [PDF]

Bio Protoc
Artificial metalloenzymes (ArMs) hold great promise for expanding the toolbox of non-natural transformations usable in living systems, such as cells, plants, and animals.
Wang K, Zhang G, Zhang L, Bai Y, Wu T.
europepmc   +2 more sources

Liquid-liquid phase separation driven by charge heterogeneity

Communications Physics
Despite the intrinsic charge heterogeneity of proteins plays a crucial role in the liquid-liquid phase separation (LLPS) of a broad variety of protein systems, our understanding of the effects of their electrostatic anisotropy is still in its early ...
Daniele Notarmuzi, Emanuela Bianchi
doaj   +5 more sources