Results 31 to 40 of about 6,019,478 (263)
Kinase regulation by liquid–liquid phase separation
Trends in Cell Biology, 2023 Liquid-liquid phase separation (LLPS) is emerging as a mechanism of spatiotemporal regulation that could answer long-standing questions about how order is achieved in biochemical signaling. In this review we discuss how LLPS orchestrates kinase signaling, either by creating condensate structures that are sensed by kinases or by direct LLPS of kinases ...
Tania P. López-Palacios +1 more
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Microfluidic characterization of macromolecular liquid-liquid phase separation [PDF]
Lab on a Chip, 2020 Abstract Liquid-liquid phase separation plays important roles in the compartmentalization of cells. Developing an understanding of how phase separation is encoded in biomacromolecules requires quantitative mapping of their phase behavior.
Anne Bremer +2 more
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Cells, 2022 Membrane-enclosed organelle compartmentalization is not the only way by which cell processes are spatially organized. Phase separation is emerging as a new driver in the organization of membrane-less compartments and biological processes.
Klizia Maccaroni +3 more
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Elastic ripening and inhibition of liquid–liquid phase separation [PDF]
Nature Physics, 2020 Phase separation has recently emerged as an important organizational principle in the dense and heterogeneous environment within living cells. Here, we use a synthetic system to show that compressive stresses in a polymer network suppress phase separation of the solvent that swells it. These stresses create a barrier to droplet nucleation that leads to
Kathryn A. Rosowski +5 more
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Comprehensive Regulation of Liquid–Liquid Phase Separation of Polypeptides
Molecules, 2023 The elucidation of the molecular driving forces responsible for Liquid–liquid Phase Separation (LLPS) of proteins and nucleic acids within living cells is crucial for understanding its biological functions and its role in related diseases. In the present
Yanwei Wang +3 more
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CTP-controlled liquid–liquid phase separation of ParB
Journal of Molecular Biology, 2022 The ParABS system is supposed to be responsible for plasmid partitioning and chromosome segregation in bacteria. ParABS ensures a high degree of fidelity in inheritance by dividing the genetic material equally between daughter cells during cell division.
Babl, L. +5 more
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Liquid-Liquid Phase Separation in Nucleation Process of Biomineralization
Frontiers in Chemistry, 2022 Biomineralization is a typical interdisciplinary subject attracting biologists, chemists, and geologists to figure out its potential mechanism. A mounting number of studies have revealed that the classical nucleation theory is not suitable for all ...
Da Qin, Zhen He, Peng Li, Shutian Zhang
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Effects of molecular weight and temperature on liquid–liquid phase separation in particles containing organic species and inorganic salts [PDF]
Atmospheric Chemistry and Physics, 2015 Atmospheric particles containing organic species and inorganic salts may undergo liquid–liquid phase separation when the relative humidity varies between high and low values.
Y. You, A. K. Bertram
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Liquid–Liquid Phase Separation and Protective Protein Aggregates in Bacteria
Molecules, 2023 Liquid–liquid phase separation (LLPS) and the formation of membraneless organelles (MLOs) contribute to the spatiotemporal organization of various physiological processes in the cell.
Dorota Kuczyńska-Wiśnik +2 more
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The effect of polymer length in liquid-liquid phase separation
Cell Reports Physical Science, 2023 Understanding the thermodynamics that drive liquid-liquid phase separation (LLPS) is quite important given the number of diverse biomolecular systems undergoing this phenomenon. Many studies have focused on condensates of long polymers, but very few systems of short-polymer condensates have been observed and studied.
Gilberto Valdes-Garcia +5 more
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