Results 1 to 10 of about 6,632 (114)
Liquid-liquid phase separation and its regulation of the BACH2 intrinsically disordered region [PDF]
Biophysics and PhysicobiologyIntrinsically disordered regions (IDRs) are vital for several cellular processes. They play a significant role in liquid-liquid phase separation (LLPS). LLPS enhances reaction efficiency by locally concentrating proteins and nucleic acids.
Hironori Hayashi +6 more
doaj +2 more sources
Liquid–liquid phase separation in human health and diseases
Signal Transduction and Targeted Therapy, 2021 Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets).
Bin Wang +6 more
doaj +2 more sources
A Protocol for Regulating Protein Liquid–Liquid Phase Separation Using NMR-Guided Mutagenesis [PDF]
Methods and ProtocolsLiquid–liquid phase separation (LLPS) underlies the formation of membraneless cellular compartments, yet experimental strategies that directly connect quantitative LLPS behavior with residue-level structural information remain limited.
Mayu Enomoto-Kusano +3 more
doaj +2 more sources
Liquid–liquid phase separation in neural development [PDF]
Cellular and Molecular Life SciencesLiquid–liquid phase separation (LLPS) is a physicochemical process in which a homogeneous mixture of molecules separates into a denser phase originating from preferential self-assembly, driven by multivalent interactions, frequently mediated by ...
Sara Surini, Ivan de Curtis
doaj +2 more sources
Modeling liquid-liquid phase separation and its impact on proteasomal substrate degradation [PDF]
Computational and Structural Biotechnology JournalThe proteasome, central to ubiquitin-proteasome mediated degradation of substrate proteins, undergoes liquid-liquid phase separation (LLPS) during substrate processing.
Di Wu, Qi Ouyang, Hongli Wang
doaj +2 more sources
Liquid-liquid phase separation in super enhancer-driven oncogenesis: mechanisms, immune evasion, and therapeutic implications [PDF]
Frontiers in Cell and Developmental BiologyLiquid-Liquid Phase Separation (LLPS) allows biomolecules to form membrane-less organelles or condensates through weak multivalent interactions. Recent studies have revealed the critical role of LLPS in super-enhancer (SE)-associated tumorigenesis ...
Ruoxi Yu, Deyu Sun, Chuang Zhang
doaj +2 more sources
Protein Condensates and Protein Aggregates: In Vitro, in the Cell, and In Silico
Frontiers in Bioscience-Landmark, 2023 Similar to other polypeptides and electrolytes, proteins undergo phase transitions, obeying physicochemical laws. They can undergo liquid-to-gel and liquid-to-liquid phase transitions.
Katja Venko, Eva Žerovnik
doaj +1 more source
Disease Models & Mechanisms, 2022 RNA regulation in mammalian cells requires complex physical compartmentalisation, using structures thought to be formed by liquid-liquid phase separation. Disruption of these structures is implicated in numerous degenerative diseases.
Selma Gulyurtlu +6 more
doaj +1 more source
A high-throughput method for exploring the parameter space of protein liquid-liquid phase separation
Cell Reports Physical Science, 2022 Summary: Numerous proteins can undergo liquid-liquid phase separation (LLPS) in various biological processes. However, it remains a challenge to systematically evaluate the LLPS ability of proteins.
Yichen Li, Jinge Gu, Cong Liu, Dan Li
doaj +1 more source
Virulence, 2022 MERS-CoV infection can damage the cellular metabolic processes, but the underlying mechanisms are largely unknown. Through screening, we found non-structural protein 1 (nsp1) of MERS-CoV could inhibit cell viability, cell cycle, and cell migration ...
Zhaoyi Pan +5 more
doaj +1 more source