Liquid–liquid phase separation and morphologies in organic particles consisting of α-pinene and β-caryophyllene ozonolysis products and mixtures with commercially available organic compounds [PDF]
Atmospheric Chemistry and Physics, 2020 Liquid–liquid phase separation (LLPS) in organic aerosol particles can impact several properties of atmospheric particulate matter, such as cloud condensation nuclei (CCN) properties, optical properties, and gas-to-particle partitioning.
Y.-C. Song +6 more
doaj +1 more source
CircFAM65A/CANX Condensates Sequester FAM134B to Inhibit ER-phagy and Suppress Hepatocellular Carcinoma Progression. [PDF]
Adv Sci (Weinh)The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Ru W +15 more
europepmc +2 more sources
On LLP(k) grammars and languages
Theoretical Computer Science, 1981 AbstractThe paper studies the family of LLP(k) grammars introduced by Lomet. Two new grammatical characterizations for this class are presented. The first one shows that these grammars form an extension of strict deterministic grammars, in particular, any strict deterministic grammar is an LLP(0) one.
openaire +1 more source
Liquid − liquid phase separation of tau: Driving forces, regulation, and biological implications
Neurobiology of Disease, 2023 The past 15 years have witnessed an explosion in the studies of biomolecular condensates that are implicated in numerous biological processes and play vital roles in human health and diseases.
Ping Li +5 more
doaj +1 more source
Evaluating LLP Methods: Challenges and Approaches
CoRR, 2023 Learning from Label Proportions (LLP) is an established machine learning problem with numerous real-world applications. In this setting, data items are grouped into bags, and the goal is to learn individual item labels, knowing only the features of the data and the proportions of labels in each bag.
Gabriel Franco +2 more
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Liquid–liquid phase separation in organic particles containing one and two organic species: importance of the average O : C [PDF]
Atmospheric Chemistry and Physics, 2018 Recently, experimental studies have shown that liquid–liquid phase separation (LLPS) can occur in organic particles free of inorganic salts. Most of these studies used organic particles consisting of secondary organic materials generated in ...
M. Song +4 more
doaj +1 more source
Frontiers in Immunology, 2023 Spatiotemporal separation of cellular components is vital to ensure biochemical processes. Membrane-bound organelles such as mitochondria and nuclei play a major role in isolating intracellular components, while membraneless organelles (MLOs) are ...
Shuai Yang +12 more
doaj +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
LLPS vs. LLCPS: analogies and differences
Soft Matter, 2023 We compare the process of Liquid–Liquid Phase Separation (LLPS) of flexible macromolecules, with the Liquid–Liquid Crystalline Phase Separation (LLCPS) of rigid fibrils, which involves the formation of a liquid phase with a directional alignment.
Paride Azzari, Raffaele Mezzenga
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