Liquid-Liquid Phase Separation (LLPS) in Tumor Biology: Special Focus on the Process of Transcription. [PDF]
Int J Mol SciLiquid–liquid phase separation (LLPS) has attracted considerable attention in cell biology as a potentially widespread organizing principle in the cellular environment.
Chen W, Yang Z, Zhou Q, Cheng B.
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Diverging Liquid-Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins. [PDF]
Adv Sci (Weinh)Fibers spun from the MaSp1‐derivative as well as MaSp1‐MaSp2‐mixtures provide a deeper insight into the assembly process of the spidroins and how hierarchical architectures of spider silk fibers could be achieved. ABSTRACT Spider silk fibers show exceptional mechanical properties, based on their underlying spider silk proteins (spidroins) as well as a ...
Schiller T, Hayashi C, Scheibel TR.
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Sticker Valence Governs Chain Collapse and Liquid-Liquid Phase Separation in Peptide-Inspired Associative Polymers. [PDF]
Adv Sci (Weinh)Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Oh SH +7 more
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Capillary Flow Experiments (Capflex) for Thermodynamic and Kinetic Characterization of Protein LLPS at High Throughput [PDF]
, 2021 Liquid-liquid phase separation (LLPS) of proteins is a field of mounting importance to life sciences. We present a new method, Capflex, that can easily be automated, allowing rapid and accurate quantification of key parameters for LLPS.
Jacob Aunstrup, Larsen +4 more
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Adenosine triphosphate as a modulator of protein interactions and stability. [PDF]
FEBS Open BioATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Tan S, Curtis R.
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Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress
Molecular & Cellular Oncology, 2020 We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells.
Roberto Giambruno, Tiziana Bonaldi
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Liquid–liquid phase separation in human health and diseases
Signal Transduction and Targeted Therapy, 2021 Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets).
Bin Wang +6 more
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Derivative Actions and LLPs: The Need for Reform
This article examines the means by which a derivative action can be brought on behalf of a limited liability partnership (LLP) through an analysis of the recent judicial decisions that pave the way for further reforms to extend the statutory regime under
Pitsillidou, Lida
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Biomolecular Liquid–Liquid Phase Separation for Biotechnology
BioTech, 2023 The liquid–liquid phase separation (LLPS) of biomolecules induces condensed assemblies called liquid droplets or membrane-less organelles. In contrast to organelles with lipid membrane barriers, the liquid droplets induced by LLPS do not have distinct ...
Sumit Shil +3 more
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Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes
Cell Discovery, 2022 As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors for promoting insulin/IGF signals.
Xiu Kui Gao +17 more
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