Results 11 to 20 of about 7,849 (242)

Sticker Valence Governs Chain Collapse and Liquid-Liquid Phase Separation in Peptide-Inspired Associative Polymers. [PDF]

Adv Sci (Weinh)
Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Oh SH, Lee J, Lee S, Jung R, Lee S, Hur SM, Lee DW, Choi SH.   +7 more
europepmc   +2 more sources

Diverging Liquid-Liquid Phase Separation Behavior of Different Recombinant Major Ampullate Spidroins. [PDF]

Adv Sci (Weinh)
Fibers spun from the MaSp1‐derivative as well as MaSp1‐MaSp2‐mixtures provide a deeper insight into the assembly process of the spidroins and how hierarchical architectures of spider silk fibers could be achieved. ABSTRACT Spider silk fibers show exceptional mechanical properties, based on their underlying spider silk proteins (spidroins) as well as a ...
Schiller T, Hayashi C, Scheibel TR.
europepmc   +2 more sources

Prion-Like Protein LENG8-Mediated Nucleation Drives Stress Granule Assembly. [PDF]

Adv Sci (Weinh)
LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Zhang M, Wang X, Teng Y, Wu Z, Fan J, Zhu H, Dai P.   +6 more
europepmc   +2 more sources

Study liquid–liquid phase separation with optical microscopy: A methodology review

APL Bioengineering, 2023
Intracellular liquid–liquid phase separation (LLPS) is a critical process involving the dynamic association of biomolecules and the formation of non-membrane compartments, playing a vital role in regulating biomolecular interactions and organelle ...
Xiufeng Zhang, Haoyang Li, Yue Ma, Dongping Zhong, Shangguo Hou   +4 more
doaj   +1 more source

Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress

Molecular & Cellular Oncology, 2020
We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells.
Roberto Giambruno, Tiziana Bonaldi
doaj   +1 more source

Systematic Analysis of Molecular Characterization and Clinical Relevance of Liquid–Liquid Phase Separation Regulators in Digestive System Neoplasms

Frontiers in Cell and Developmental Biology, 2022
Background: The role of liquid–liquid phase separation (LLPS) in cancer has also attracted more and more attention, which is found to affect transcriptional regulation, maintaining genomic stability and signal transduction, and contribute to the ...
Yaxin Zhang, Jie Li, Dan Feng, Xiaobo Peng, Bin Wang, Ting Han, Yingyi Zhang   +6 more
doaj   +1 more source

Liquid–liquid phase separation in human health and diseases

Signal Transduction and Targeted Therapy, 2021
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets).
Bin Wang, Lei Zhang, Tong Dai, Ziran Qin, Huasong Lu, Long Zhang, Fangfang Zhou   +6 more
doaj   +1 more source

Biomolecular Liquid–Liquid Phase Separation for Biotechnology

BioTech, 2023
The liquid–liquid phase separation (LLPS) of biomolecules induces condensed assemblies called liquid droplets or membrane-less organelles. In contrast to organelles with lipid membrane barriers, the liquid droplets induced by LLPS do not have distinct ...
Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi, Daisuke Miyoshi   +3 more
doaj   +1 more source

Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes

Cell Discovery, 2022
As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors for promoting insulin/IGF signals.
Xiu Kui Gao, Xi Sheng Rao, Xiao Xia Cong, Zu Kang Sheng, Yu Ting Sun, Shui Bo Xu, Jian Feng Wang, Yong Heng Liang, Lin Rong Lu, Hongwei Ouyang, Huiqing Ge, Jian-sheng Guo, Hang-jun Wu, Qi Ming Sun, Hao-bo Wu, Zhang Bao, Li Ling Zheng, Yi Ting Zhou   +17 more
doaj   +1 more source

Whither Remoteness? Wellesley Partners LLP v Withers LLP [PDF]

The Modern Law Review, 2016
In Wellesley v Withers, the Court of Appeal held that where a defendant is concurrently liable in tort and contract, the contractual rules for the remoteness of loss must apply. Two principal reasons emerge from the judgments. The first, that each party has had the chance to alert the other to unusual risks, is valid but often unconvincing.
openaire   +2 more sources