Results 11 to 20 of about 15,588 (275)
Crystals, 2021 Liquid–liquid phase separation (LLPS) during the crystallization of active pharmaceutical ingredients (APIs) often causes agglomeration and other quality issues in crystal products; thus, it should be avoided if possible.
Wei Han Lin +3 more
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Study liquid–liquid phase separation with optical microscopy: A methodology review
APL Bioengineering, 2023 Intracellular liquid–liquid phase separation (LLPS) is a critical process involving the dynamic association of biomolecules and the formation of non-membrane compartments, playing a vital role in regulating biomolecular interactions and organelle ...
Xiufeng Zhang +4 more
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Biomolecules, 2022 Intrinsically disordered proteins (IDPs) are essential players in the assembly of biomolecular condensates during liquid–liquid phase separation (LLPS). Disordered regions (IDRs) are significantly exposed to the solvent and, therefore, highly influenced ...
Carlos Pintado-Grima +2 more
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Journal of Hematology & Oncology, 2023 Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise spatiotemporal coordination in living cells through biomolecular condensate (BMC) formation via dynamic aggregation. LLPS changes individual molecules into membrane-free,
Le-Wei Zheng, Cui-Cui Liu, Ke-Da Yu
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Frontiers in Cell and Developmental Biology, 2022 Background: The role of liquid–liquid phase separation (LLPS) in cancer has also attracted more and more attention, which is found to affect transcriptional regulation, maintaining genomic stability and signal transduction, and contribute to the ...
Yaxin Zhang +6 more
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Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress
Molecular & Cellular Oncology, 2020 We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells.
Roberto Giambruno, Tiziana Bonaldi
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Biomolecular Liquid–Liquid Phase Separation for Biotechnology
BioTech, 2023 The liquid–liquid phase separation (LLPS) of biomolecules induces condensed assemblies called liquid droplets or membrane-less organelles. In contrast to organelles with lipid membrane barriers, the liquid droplets induced by LLPS do not have distinct ...
Sumit Shil +3 more
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Modeling the gas-particle partitioning of secondary organic aerosol: the importance of liquid-liquid phase separation [PDF]
, 2012 The partitioning of semivolatile organic compounds between the gas phase and aerosol particles is an important source of secondary organic aerosol (SOA).
Seinfeld, J. H., Zuend, A.
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New Physics Opportunities for Long-Lived Particles at Electron-Proton Colliders [PDF]
, 2017 Future electron-proton collider proposals like the LHeC or the FCC-eh can supply 1/ab of collisions with a center-of-mass energy in the TeV range, while maintaining a clean experimental environment more commonly associated with lepton colliders. We point
Curtin, David +3 more
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Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes
Cell Discovery, 2022 As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors for promoting insulin/IGF signals.
Xiu Kui Gao +17 more
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