Results 11 to 20 of about 7,152 (243)
Liquid-liquid phase separation and its regulation of the BACH2 intrinsically disordered region [PDF]
Biophysics and PhysicobiologyIntrinsically disordered regions (IDRs) are vital for several cellular processes. They play a significant role in liquid-liquid phase separation (LLPS). LLPS enhances reaction efficiency by locally concentrating proteins and nucleic acids.
Hironori Hayashi +6 more
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A Protocol for Regulating Protein Liquid–Liquid Phase Separation Using NMR-Guided Mutagenesis [PDF]
Methods and ProtocolsLiquid–liquid phase separation (LLPS) underlies the formation of membraneless cellular compartments, yet experimental strategies that directly connect quantitative LLPS behavior with residue-level structural information remain limited.
Mayu Enomoto-Kusano +3 more
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Phase separation and the tumor microenvironment [PDF]
Cell Communication and SignalingLiquid-Liquid Phase Separation (LLPS) is a physicochemical process which involves biomolecules spontaneously assembling into membrane-less biomolecular condensates through multivalent weak interactions.
Wangwang Liu +5 more
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Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress
Molecular & Cellular Oncology, 2020 We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells.
Roberto Giambruno, Tiziana Bonaldi
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Biomolecular Liquid–Liquid Phase Separation for Biotechnology
BioTech, 2023 The liquid–liquid phase separation (LLPS) of biomolecules induces condensed assemblies called liquid droplets or membrane-less organelles. In contrast to organelles with lipid membrane barriers, the liquid droplets induced by LLPS do not have distinct ...
Sumit Shil +3 more
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International Journal For Multidisciplinary Research, 2023 Allergic rhinitis, an inflammatory immune response to airborne allergens affecting the nasal mucosa, can cause distressing symptoms and disrupt daily life. It often coexists with asthma and lacks an effective conventional treatment. This study explores the successful Ayurvedic treatment of a 51-year-old female patient with perennial allergic rhinitis ...
Ranjana Kaushal -, Deeksha Sharma -
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Frontiers in Cell and Developmental Biology, 2022 Background: The role of liquid–liquid phase separation (LLPS) in cancer has also attracted more and more attention, which is found to affect transcriptional regulation, maintaining genomic stability and signal transduction, and contribute to the ...
Yaxin Zhang +6 more
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Whither Remoteness? Wellesley Partners LLP v Withers LLP [PDF]
The Modern Law Review, 2016 In Wellesley v Withers, the Court of Appeal held that where a defendant is concurrently liable in tort and contract, the contractual rules for the remoteness of loss must apply. Two principal reasons emerge from the judgments. The first, that each party has had the chance to alert the other to unusual risks, is valid but often unconvincing.
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Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes
Cell Discovery, 2022 As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors for promoting insulin/IGF signals.
Xiu Kui Gao +17 more
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Effects of Mass Change on Liquid–Liquid Phase Separation of the RNA-Binding Protein Fused in Sarcoma
Biomolecules, 2023 In recent years, many experimental and theoretical studies of protein liquid–liquid phase separation (LLPS) have shown its important role in the processes of physiology and pathology.
Weiqian Dong +4 more
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